Abstract: A modified release dosage form comprising at least one active ingredient and at least two cores surrounded by a shell is provided. The shell comprises at least one opening and provides for modified release of active ingredient upon contacting of the dosage form with a liquid medium. At least one of the cores is distal from the opening. In a preferred embodiment, the dosage form has a pulsatile release profile.

Abstract: This invention relates to substantially anhydrous warming, non-toxic and nonirritating lubricating compositions containing polyols and preferably an insulating agent. The invention also relates to methods of using such compositions for lubrication, administration of active ingredients and for preventing or treating dysmenorrhea.

Abstract: Physiologically acceptable films, including edible films, are disclosed. The films include a water soluble film-forming polymer such as pullulan. Edible films are disclosed that include pullulan and antimicrobially effective amounts of the essential oils thymol, methyl salicylate, eucalyptol and menthol. The edible films are effective at killing the plaque-producing germs that cause dental plaque, gingivitis and bad breath. The film can also contain pharmaceutically active agents. Methods for producing the films are also disclosed.

Abstract: The present invention relates to apparatus, methods, and processes for making solid dosage forms comprising at least one active ingredient, a core and shell configuration, wherein the shell comprises a hardenable material, such as a thermal-gelling polymer, for example gelatin; and the shell is provided with at least one opening. The opening(s) are formed while the shell is still in a softened state.

Abstract: A floss comprising: a fiber substrate; and a uniform coating comprising a colorant, wherein the color of the coating is different than the color of the fiber substrate is disclosed. The floss is useful as an indicator floss.

Abstract: Customizable dosage forms are provided. The flavor, color, sweetness, or texture of the dosage forms may be customized directly by the consumer.

Abstract: The invention features a child resistant, moveable closure member and container device and an overcap and container device. The overcap has opposed end walls and opposed sidewalls, with at least one leading locking pin and at least one trailing locking pin in at least one of said sidewalls. The inner closure may have at least one guiding bar, which extends downwardly from its lower surface, that is compatible in shape with an opening slot that may be in at least one of the sidewalls along the upper body of the container. The container further has a fixed cover portion facing the inner closure with a dispensing opening therethrough. At least one of the container sidewalls may have a closing notch, a stopping notch distal to the closing notch, and an opening notch therebetween.

Abstract: Systems, methods and apparatuses for manufacturing dosage forms, and to dosage forms made using such systems, methods and apparatuses are provided. Novel compression, thermal cycle molding, and thermal setting molding modules are disclosed. One or more of such modules may be linked, preferably via novel transfer device, into an overall system for making dosage forms.

Abstract: A packaged supply of individual doses of a personal care product, e.g., strips of a water-soluble film that contains a pharmaceutically active material, comprises the combination of a) a tray; b) a plurality of substantially identical packets uniformly stacked in the tray, each packet having a pouch portion that holds a single dose of the product and a tab portion releasably connected to the pouch portion; c) retention means for holding the tab portions of the stacked packets in the tray; and d) a cover that is movably connected to the tray, the cover being movable between a closed position in which the stack of packets is enclosed within the tray and an open position in which the pouch portion of the topmost packet on the stack is sufficiently exposed that its front edge can be gripped, allowing the pouch portion to be pulled away from the restrained tab portion to which it is connected, thereby releasing that pouch portion from the tray.

Abstract: A method and apparatus of applying a particulate material to a substrate includes applying adhesive to the substrate and passing the substrate through a chamber in which a particulate material is suspended in a fluid in order to adhere the particulate material to the substrate.