Abstract: An electron paramagnetic resonance (EPR) spectrometer employing a reference arm microwave bridge provides efficient, simultaneous generation of orthogonal I and Q signals. The simultaneous generation is enabled through the use of a field effect transistor (FET) microwave amplifier in the signal arm feeding a balanced quadrature mixer. The I and Q signals are then combined to produce a signal suitable for use as a discriminator in an automatic frequency control (AFC) circuit. An important characteristic of the discriminator signal is that it is independent of the relative phase angle .alpha. between the reference arm and signal arm of the bridge. In a further embodiment, an apparatus is disclosed which computes .alpha. from the I and Q signals, and uses the computed value for .alpha. to extract pure absorption and pure dispersion information from the I and Q signals regardless of the setting of .alpha. in the bridge.

Abstract: Counter Rotating Current (CRC) pairs of loop-gap resonators are combined with planar pairs of loop-gap resonators to form networks of NMR local coils. A first embodiment is a quadrature probe in which a planar pair is sandwiched between the loop-gap resonators of the CRC pair. In a plurality of other embodiments, CRC pairs, planar pairs, and other types of local coils are arranged adjacent to one another to form networks of NMR local coils with an enlarged net region of sensitivity. In a further embodiment of the invention, an excitation coil operated in an excite/receive mode is combined with intrinsically isolated local detectors to form an NMR detection network.

Abstract: In vitro cell culture systems for anchorage-dependent mammalian cells using solid substrates of mitogenic calcium compounds, such as hydroxyapatite and tricalcium phosphate forms of calcium phosphate and calcium carbonate. The calcium solid substrates can be in the form of granules with a particle size of at least 0.050 mm. or in the form of solid bodies and may be either porous or non-porous. Unique features of cells cultured in the stated in vitro cell culture systems include the growth of cells in layers many cells thick, growth of cells that maintain their phenotype and the ability to culture cells for extended periods of time.

Abstract: A local coil for use in NMR imaging includes a pair of loop-gap resonators which are geometrically arranged to be intrinsically isolated. The local coil also includes passive decoupling means to completely decouple the local coil during excitation. In a first embodiment, the pair of loop-gap resonators are disposed axially and the passive decoupling means comprises a pair of back-to-back diodes across the loop-gap resonators. In a second embodiment, the pair of loop-gap resonators are disposed in a plane and the passive decoupling means comprises two single turn loops inside each loop-gap resonator with back-to-back diodes across an open segment of each single turn loop. During excitation, the diodes fire thereby lowering the Q and shifting the resonant frequency of the local coil. Using a combination of intrinsic isolation and passive decoupling, the local coil is completely decoupled from the excitation field.

Abstract: Counter Rotating Current (CRC) pairs of loop-gap resonators are combined with planar pairs of loop-gap resonators to form networks of NMR local coils. A first embodiment is a quadrature probe in which a planar pair is sandwiched between the loop-gap resonators of the CRC pair. In a plurality of other embodiments, CRC pairs, planar pairs, and other types of local coils are arranged adjacent to one another to form networks of NMR local coils with an enlarged net region of sensitivity.