Patents Assigned to MDS Analytical Technologies, a business unit of MDS Inc.
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Publication number: 20110315870Abstract: Systems and methods for analyzing compounds in a sample. In one embodiment, the present technology is directed towards a method of analyzing a sample, comprising: emitting ions from the sample; selectively filtering the emitted ions for at least one designated trigger ion; fragmenting the designated trigger ions; scanning for a designated trigger ion fragment; and upon detecting the designated trigger ion fragment, scanning for at least one confirmatory ion fragment.Type: ApplicationFiled: September 9, 2011Publication date: December 29, 2011Applicants: Applera Corporation, MDS Analytical Technologies, a business unit of MDS Inc., doing buiness through its Sciex divisionInventors: Chris M. LOCK, Nic Bloomfield
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Patent number: 8084736Abstract: A mass spectrometer system including a differential mobility spectrometer and a mass spectrometer at least partially sealed to, and in fluid communication, with, the differential mobility spectrometer, together with a related method, are provided. The mass spectrometer system can be operable to, and method can comprise, a) maintaining the differential mobility spectrometer at an internal operating pressure; b) providing ions to the differential mobility spectrometer; c) maintaining the mass spectrometer at a vacuum pressure lower than the internal operating pressure to draw a gas flow including the ions through the differential mobility spectrometer and into the vacuum chamber; and, d) modifying the gas flow between the differential mobility spectrometer and the mass spectrometer to change a gas flow rate through the differential mobility spectrometer.Type: GrantFiled: May 28, 2009Date of Patent: December 27, 2011Assignee: MDS Analytical Technologies, a business unit of MDS Inc.Inventors: Bradley Schneider, Tom Covey, Erkin Nazarov
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Publication number: 20110183431Abstract: A mass analysis system including a low pressure dissociation region and a differential mobility spectrometer. The differential mobility spectrometer including at least one pair of filter electrodes defining an ion flow path where the filter electrodes generate an electric field for passing through a selected portion of the sample ions based on the mobility characteristics of the sample ions. The differential mobility spectrometer also includes a voltage source that provides DC and RF voltages to at least one of the filter electrodes to generate the electric field, an ion inlet that receives sample ions that have passed through the low pressure dissociation region, and an ion outlet that outputs the selected portion of the sample ions. A mass spectrometer receives some or all of the selected portion of the sample ions.Type: ApplicationFiled: January 28, 2011Publication date: July 28, 2011Applicants: MDS Analytical Technologies, a business Unit of MDS, Inc., Applied Biosystems (Canada) Inc.Inventors: Thomas R. Covey, Bradley B. Schneider
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Publication number: 20110174965Abstract: Methods for cooling ions retained in an ion trap are described. In various embodiments, a cooling gas is delivered into a linear ion trap causing a non-steady state pressure elevation in at least a portion of the trap above about 8×10?5 Torr for a duration less than the ion-retention time. In various embodiments, the duration of pressure elevation can be based upon a period of time required for an ion to lose a desired amount of its kinetic energy.Type: ApplicationFiled: January 26, 2009Publication date: July 21, 2011Applicants: MDS Analytical Technologies, a business unit of MDS Inc.,doing business through its Sciex division, Life Technologies CorporationInventor: Bruce Collings
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Patent number: 7847248Abstract: Ion trap apparatus and methods for efficiently addressing the effects of charge space caused by ion trap overfilling, useful in linear ion traps of mass spectrometers.Type: GrantFiled: November 18, 2008Date of Patent: December 7, 2010Assignees: MDS Analytical Technologies, a business unit of MDS Inc., Applied Biosystems, Inc.Inventor: Bruce A. Collings
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Patent number: 7692143Abstract: A method of operating a mass spectrometer having an elongated rod set and a set of auxiliary electrodes is provided, the rod set having an entrance end and an exit end and a longitudinal axis. The method comprises a) admitting ions into the entrance end of the rod set; b) trapping at least some of the ions in the rod set by producing a barrier field at an exit member adjacent to the exit end of the rod set and by producing an RF field between the rods of the rod set; and, c) providing an auxiliary AC excitement voltage to the set of auxiliary electrodes to energize a first group of ions of a selected mass to charge.Type: GrantFiled: August 15, 2007Date of Patent: April 6, 2010Assignees: MDS Analytical Technologies, a business unit of MDS Inc., Applied Biosystems (Canada) LimitedInventor: Mircea Guna
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Publication number: 20100078551Abstract: A method and apparatus for multiplexing ions in an MSn mass spectrometer is provided. Ion are filtered to produce a group of ions of interest, the group of ions below a space charge limit of the MSn mass spectrometer. At least a portion of the group of ions are fragmented to form a fragmented group of ions. At least a portion of the fragmented group are stored such that a plurality of portions of the fragmented group can be sequentially selected for mass spectrometry analysis. Each of the plurality of portions of the fragmented group are sequentially selected and re-fragmented prior to mass spectrometry analysis. Each of the plurality of portions of the fragmented group are analyzed, via mass spectrometry, once each of the plurality of portions of the fragmented group has been fragmented.Type: ApplicationFiled: September 29, 2009Publication date: April 1, 2010Applicants: MDS Analytical Technologies, a business unit of MDS, Inc., Applied Biosystems Inc.Inventor: Alexandre Loboda
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Patent number: 7679053Abstract: A method for introducing samples through a boundary member partially defining a chamber at an entrance point coaxial to a sampling inlet of a mass spectrometer is described. Field-free conditions can be established in at least one region of the chamber. The sample can be introduced adjacent to the sampling inlet, and introducing at least a second sample can be introduced through at least one other entrance point in the chamber not adjacent to the sampling inlet. An apparatus having a sampling inlet and a boundary member partially defining a chamber is also described. Field-free conditions can be established in at least one region of the chamber, and there can be a first aperture in the boundary member through which a source emits sample. Related devices, uses and mass spectrometers are also described.Type: GrantFiled: September 25, 2007Date of Patent: March 16, 2010Assignees: MDS Analytical Technologies, A Business Unit of MDS Inc., Applera CorporationInventors: Bradley B. Schneider, Thomas R. Covey
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METHOD AND SYSTEM FOR PROVIDING A MODIFIER TO A CURTAIN GAS FOR A DIFFERENTIAL MOBILITY SPECTROMETER
Publication number: 20090294648Abstract: A system including a differential mobility spectrometer is described as is a method of operating the system including the differential mobility spectrometer.Type: ApplicationFiled: May 27, 2009Publication date: December 3, 2009Applicants: MDS Analytical Technologies, a business unit of MDS Inc., Life Technologies CorporationInventors: Bradley Schneider, Thomas Covey -
Publication number: 20090294650Abstract: A mass spectrometer system including a differential mobility spectrometer and a mass spectrometer at least partially sealed to, and in fluid communication, with, the differential mobility spectrometer, together with a related method, are provided. The mass spectrometer system can be operable to, and method can comprise, a) maintaining the differential mobility spectrometer at an internal operating pressure; b) providing ions to the differential mobility spectrometer; c) maintaining the mass spectrometer at a vacuum pressure lower than the internal operating pressure to draw a gas flow including the ions through the differential mobility spectrometer and into the vacuum chamber; and, d) modifying the gas flow between the differential mobility spectrometer and the mass spectrometer to change a gas flow rate through the differential mobility spectrometer.Type: ApplicationFiled: May 28, 2009Publication date: December 3, 2009Applicants: MDS Analytical Technologies a business unit of MDS Inc., Life Technologies CorporationInventors: Bradley Schneider, Tom Covey, Erkin Nazarov
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Patent number: 7601952Abstract: A method of operating a mass spectrometer having a rod set is provided. The rod set has a first end, a second end opposite to the first end, and a longitudinal axis extending between the first end and the second end.Type: GrantFiled: July 17, 2007Date of Patent: October 13, 2009Assignees: MDS Analytical Technologies, a business unit of MDS Inc., Applied Biosystems, Inc.Inventors: Jim Hager, Bruce Thomson
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Publication number: 20090236513Abstract: Systems and methods for analyzing compounds in a sample. In one embodiment, the present technology is directed towards a method of analyzing a sample, comprising: emitting ions from the sample; selectively filtering the emitted ions for at least one designated trigger ion; fragmenting the designated trigger ions; scanning for a designated trigger ion fragment; and upon detecting the designated trigger ion fragment, scanning for at least one confirmatory ion fragment.Type: ApplicationFiled: March 12, 2009Publication date: September 24, 2009Applicants: MDS Analytical Technologies, a business unit of MDS Inc., doing buiness through its Sciex division, Applera CorporationInventors: Chris M. LOCK, Nic BLOOMFIELD
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Publication number: 20090194686Abstract: Methods for fragmenting ions retained in an ion trap are described. In various embodiments, a non-steady-state pressure of a neutral collision gas of less than about 5×10?4 Torr and an excitation amplitude of less than about 500 mV (peak to ground) is used to fragment ions with greater than about 80% fragmentation efficiency. In various embodiments, duration of ion excitation is greater than about 25 ms.Type: ApplicationFiled: January 26, 2009Publication date: August 6, 2009Applicant: MDS Analytical Technologies, a business unit of MDS Inc., doing business through its Sciex divisioInventors: Mircea Guna, Bruce Collings
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Publication number: 20090194684Abstract: Methods for fragmenting ions in an ion trap are described.Type: ApplicationFiled: January 26, 2009Publication date: August 6, 2009Applicants: MDS Analytical Technologies, a business unit of MDS Inc. doing business through its Sciex division, Life Technologies CorporationInventors: Mircea Guna, Yves Le Blanc, Bruce Collings
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Patent number: 7569813Abstract: A method of operating an ion trap spectrometer system having an ion trap is provided.Type: GrantFiled: August 21, 2007Date of Patent: August 4, 2009Assignees: MDS Analytical Technologies, a business unit of MDS Inc., Applied Biosystems, LLCInventor: James Hager
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Publication number: 20090189071Abstract: In a tandem mass spectrometer using a collision cell for ion fragmentation, the upper limit of the collision energy required for collision induced dissociation (CID) can be extended without reaching or going beyond the upper electrical discharge limit of the system components. The present teachings describe a method of lifting the potential energy of ions to a predetermined level sufficient for CID fragmentation while satisfying a discharge free condition. The present teaching also describes a method of lifting the potential energy of the fragment ions after CID fragmentation so that the product ions have sufficient energy for mass analysis.Type: ApplicationFiled: January 30, 2009Publication date: July 30, 2009Applicants: MDS Analytical Technologies, a Business Unit of MDS Inc., doing it business through its Sciex Div., Life Technologies Corporation, a Delaware Corp.Inventors: Igor Chernushevich, Alexandre V. Loboda
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Patent number: 7557344Abstract: The applicants' teachings provide methods, systems, and apparatus useful in operating mass spectrometers and other devices incorporating multipole rod sets or other multi-electrode devices to simultaneously contain ions of both positive and negative charges through the simultaneous application to the rods or other electrodes of both radio-frequency (RF) and alternating (AC) currents.Type: GrantFiled: July 9, 2007Date of Patent: July 7, 2009Assignees: MDS Analytical Technologies, a business unit of MDS Inc., Applera CorporationInventors: Igor Chernushevich, Alexandre Loboda
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Publication number: 20090166534Abstract: Ion trap apparatus and methods for efficiently addressing the effects of charge space caused by ion trap overfilling, useful in linear ion traps of mass spectrometers.Type: ApplicationFiled: November 18, 2008Publication date: July 2, 2009Applicants: MDS Analytical Technologies, a business unit of MDS Inc., Applied Biosystems Inc.Inventor: Bruce A. Collings
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Patent number: 7541579Abstract: A mass spectrometer and a method of operating and building same is provided in which a hexapole component is deliberately added to a substantially quadrupole field. This can result in unwanted octopole and dipole fields also being added to the substantially quadrupole field. Modifications to the mass spectrometer as well as ways of operating the mass spectrometer are provided for dealing with the unwanted octopole and dipole fields.Type: GrantFiled: February 7, 2007Date of Patent: June 2, 2009Assignees: The University of British Columbia, MDS Analytical Technologies, a business unit of MDS Inc.Inventors: Nikolai Konenkov, Frank Londry, Chuanfan Ding, Donald J. Douglas
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Publication number: 20090121126Abstract: Methods for improved separation of ions from an ion trap employing a combination of low pressure and low amplitude ion excitation, including methods for removing, from an ion trap ion population, ions having a m/z value neighboring that of an ion of interest, mass spectrometry methods providing improved resolution of ion detection, and programmable apparatus programmed with instructions therefor.Type: ApplicationFiled: September 29, 2008Publication date: May 14, 2009Applicants: MDS Analytical Technologies, a business unit of MDS Inc., APPLERA CORPORATIONInventors: Bruce A. Collings, Yves J.C. Leblanc