Abstract: An apparatus includes a fluid path, a coupling, and a nozzle. The fluid path is to carry a fluid including one or more microparticles. The coupling is located in the fluid path. The nozzle is located in the fluid path to move the fluid through a stagnant region located near the coupling.

Abstract: An apparatus includes a fluid path, a coupling, and a nozzle. The fluid path is to carry a fluid including one or more microparticles. The coupling is located in the fluid path. The nozzle is located in the fluid path to move the fluid through a stagnant region located near the coupling.

Abstract: An apparatus includes a fluid path, a coupling, and a nozzle. The fluid path is to carry a fluid including one or more microparticles. The coupling is located in the fluid path. The nozzle is located in the fluid path to move the fluid through a stagnant region located near the coupling.

Abstract: A bifunctional polyazamacrocyclic chelating agent of the formula (I): wherein: and the variables A, L, Q, Q1, X, Y, Z, Z1, m, n and r are as defined in the description of the present application. Also described is a complex of the above chelating agent to an ion of a metal ion, such as an ion of 90Y, 111Li or 177Lu; a conjugate of the complex covalently attached to a biological carrier; and a pharmaceutical composition containing the conjugate. A method of therapeutic treatment of a mammal involving administration of the pharmaceutical composition is also described.

Abstract: The invention can be summarized as follows. According to the present invention there is provided an attenuated, tumour-targeting bacterium comprising a heterologous nucleotide sequence encoding a protein permitting the accumulation of a radionuclide within the bacterium. The heterologous nucleotide sequence may encode a sodium iodide symporter protein. The invention also relates to the use of such bacteria and methods of treating diseases using the bacteria of the present invention.

Abstract: The invention can be summarized as follows. According to the present invention there is provided an attenuated, tumour-targeting bacterium comprising a heterologous nucleotide sequence encoding a protein permitting the accumulation of a radionuclide within the bacterium. The heterologous nucleotide sequence may encode a sodium iodide symporter protein. The invention also relates to the use of such bacteria and methods of treating diseases using the bacteria of the present invention.

Abstract: The present invention relates to a product irradiator having a cartridge loading system. The cartridge comprises a plurality of carriers or totes which are transported as a single mass into an irradiation chamber for radiation processing. Products contained within the totes are irradiated while on the cartridge, but individual totes are transferred around the radioactive source by a tote transfer system. The cartridge product irradiator permits quick changes of cartridges thereby minimizing the time that the radioactive source is not in use, and also permits good radiation dose uniformity in products. The cartridge product irradiator is thus highly efficient and economical to use.

Abstract: This invention relates to radioactively coated devices, preferably radioctively coated medical devices. These coated devices are characterized as having a low rate of leaching of the radioisotope from the surface of the coated device and a uniform radioactive coating, and are therefore suitable for use within biological systems. Methods for coating a device with a radioisotope comprising are also disclosed. One method comprises immersing the device within a solution containing a &ggr;, &bgr;+, &agr;, &bgr;− or &egr; (electron capture) emitting radioisotope, then exposing the immersed substrate to tuned vibrational cavitation to produce a coated substrate. A second method involves coating a substrate using electroless plating, and yet a third method involves the use of electroplating a radioisotope onto a substate of interest. With these methods, the coating procedures are followed by baking the coated substrate at a temperature below the recrystallization temperature of the substrate.

Abstract: The present invention discloses a radioactive medical device comprising a radioactive, electroplated substrate coated with at least one layer of polymer and sealed in a jacket layer. The at least one layer of polymer and jacket layer reduce leaching of a radioactive element from the electroplated substrate. The radioactive medical device is useful for radiation therapy of diseased tissue such as cancers and especially malignant tumors.

Abstract: Glyphosate and other phosphonates including the bone resorption-inhibiting bisphosphonates are extracted from samples using immobilized forms of zinc, including zinc methacrylate polymers. The method provides a simple and sensitive method for detecting phosphonates present in aqueous samples, including wastewater and urine.

Abstract: An apparatus and method for irradiating a product or product stack with a relatively even radiation dose distribution (low dose uniformity ratio (DUR)). The apparatus comprises a radiation source for producing radiation in the range of X-rays or greater, an adjustable collimator for producing a radiation beam of a desired geometry, a turn-table capable of receiving a product stack and a control system capable of adjusting the adjustable collimator to vary the geometry of the radiation beam as the product stack is rotated in the radiation beam. Also disclosed is the modulation of the radiation beam energy and power and varying the angular rotational velocity of the product stack in a radiation beam to achieve a low dose uniformity ratio in the product stack.

Abstract: An apparatus and method for irradiating a product or product stack with a relatively even radiation dose distribution (low dose uniformity ratio (DUR). The apparatus comprises a radiation source for producing radiation in the range of X-rays or greater, an adjustable collimator for producing a radiation beam of a desired geometry, a turn-table capable of receiving a product stack and a control system capable of adjusting the adjustable collimator to vary the geometry of the radiation beam as the product stack is rotated in the radiation beam. Also disclosed is the modulation of the radiation beam energy and power and varying the angular rotational velocity of the product stack in a radiation beam to achieve a low dose uniformity ratio in the product stack.

Abstract: This invention relates to radioactively coated devices, preferably radioactively coated medical devices. These coated devices are characterized as having a low rate of leaching of the radioisotope from the surface of the coated device and a uniform radioactive coating, and are therefore suitable for use within biological systems. Coated medical devices are disclosed that are produced either by immersing the device within a solution containing a &ggr;, &bgr;+, &agr;, &bgr;−, &Egr; (electron capture) emitting radioisotope, then exposing the immersed substrate to tuned vibrational cavitation, by electroless plating, or by electroplating a radioisotope onto a substrate of interest. The medical devices so produced are then baked at a temperature below the recrystallization temperature of the medical device.