Patents Assigned to MDS Proteomics, Inc.
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Patent number: 6864089Abstract: This invention related to methods useful in the labeling of multiple polypeptide samples and subsequent analysis of these samples by mass spectrometry, particularly in the high throughput proteomic setting.Type: GrantFiled: June 11, 2001Date of Patent: March 8, 2005Assignee: MDS Proteomics, Inc.Inventors: Daniel Figeys, Matthias Mann, Ian I. Stewart
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Publication number: 20040161795Abstract: The invention relates to a method for the detection and identification of amino acid modifications, such as phosphorylation, using a combination of affinity capture and mass-spectroscopy.Type: ApplicationFiled: July 25, 2003Publication date: August 19, 2004Applicant: MDS Proteomics Inc.Inventor: Jarrod A. Marto
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Patent number: 6748975Abstract: A microfluidic rotary valve and methods of manufacturing same are disclosed. The rotary valve includes a stator chip having at least one inlet and at least one outlet. The rotary valve also includes a rotor having at least one rotor channel in sealed engagement with the stator chip. The rotor rotates between valve positions preventing and allowing fluid communication between the inlets and outlets by way of the rotor channels and according to the design of the inlets, outlets and rotor channels. The stator chip includes a first planar substrate having a contact face and a second planar substrate having a contact face bonded to the contact face of the first planar substrate. The first planar substrate defines a first portion of the inlet and outlet, and the second planar substrate defines a second portion of the inlet and outlet.Type: GrantFiled: December 26, 2001Date of Patent: June 15, 2004Assignees: Micralyne Inc., MDS Inc., MDS Proteomics Inc.Inventors: Herbert A. Hartshorne, Graham H. McKinon, Pengguang Yu, Darren F. Lewis
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Patent number: 6747273Abstract: This invention relates to methods and reagents for detecting the presence of symmetrically and asymmetrically methylated arginine residues, either along or in polypeptides, using mass spectrometry. It also provides methods of determining structures of methylated arginine residues, methods of identifying substrates of PMRTs, and methods of conducting proteomic business using any of the suitable methods recited above.Type: GrantFiled: May 20, 2002Date of Patent: June 8, 2004Assignee: MDS Proteomics Inc.Inventors: Cynthia J. Brame, Linda McBroom
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Enzyme/chemical reactor based protein processing method for proteomics analysis by mass spectrometry
Publication number: 20040053356Abstract: A method and tools for the biochemical processing of protein samples towards their analysis and identification by, for example, mass spectrometry (MS). The method involves the reversible (non-covalent) immobilization, purification and concentration of proteins onto a solid surface and subsequent solid-phase enzyme-catalyzed proteolysis of the proteins. The constituent peptides are recovered in near-quantitative yields in a format ideally suited for identification by routine MS technologies. The process is easily adapted such that additional chemical and/or enzymatic transformation(s) of the immobilized proteins or peptides can be performed to facilitate the acquisition of and increase the information content obtained from the MS analysis.Type: ApplicationFiled: June 23, 2003Publication date: March 18, 2004Applicant: MDS Proteomics Inc.Inventors: Henry Duewel, Theo Goh, Thierry Le Bihan -
Patent number: 6682660Abstract: A composite paramagnetic particle and method of making are provided. In one aspect of the invention, a particle comprising a multitude of submicron polymer bead aggregates covalently cross-linked to each other to form larger diameter particles is presented. Distributed throughout the composite paramagnetic particle are vacuous cavities. Each submicron polymer bead has distributed throughout its interior and surface submicron magnetite crystals. In another aspect of the invention, composite particles are made using high energy ultrasound during polymerization of one or more vinyl monomers. In one embodiment, high energy ultrasound is used during an emulsification step and during the early stages of the polymerization process to produce micron sized composite paramagnetic particles. The particles according to the invention exhibit a high percent magnetite incorporation and water and organic solvent stability.Type: GrantFiled: May 14, 2002Date of Patent: January 27, 2004Assignee: MDS Proteomics, Inc.Inventors: Irving Sucholeiki, Nak-Ho Sung, Jun Young Lee
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Enzyme/chemical reactor based protein processing method for proteomics analysis by mass spectrometry
Publication number: 20040009567Abstract: A method and tools for the biochemical processing of protein samples towards their analysis and identification by, for example, mass spectrometry (MS). The method involves the reversible (non-covalent) immobilization, purification and concentration of proteins onto a solid surface and subsequent solid-phase enzyme-catalyzed proteolysis of the proteins. The constituent peptides are recovered in near-quantitative yields in a format ideally suited for identification by routine MS technologies. The process is easily adapted such that additional chemical and/or enzymatic transformation(s) of the immobilized proteins or peptides can be performed to facilitate the acquisition of and increase the information content obtained from the MS analysis.Type: ApplicationFiled: June 5, 2003Publication date: January 15, 2004Applicant: MDS Proteomics Inc.Inventors: Henry Duewel, Theo Goh, Thierry Le Bihan -
Publication number: 20030232014Abstract: Methods and systems of applying mass spectrometry to the analysis of peptides and amino acids, especially in the proteome setting. More particularly, the invention relates to a mass spectrometry-based method for detection of amino acid modifications, such as phosphorylation.Type: ApplicationFiled: March 3, 2003Publication date: December 18, 2003Applicants: MDS Proteomics Inc., University of VirginiaInventors: Daniel J. Burke, Mark M. Ross, P. Todd Stukenberg, Forest M. White
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Publication number: 20030166007Abstract: The invention relates to methods and reagents for identifying/isolating protein targets of chemical compounds (for example, drug candidates) using mass spectrometry. The invention provides a method for capturing and identifying proteins using tethered small-molecule probes. This technology also allows the market expansion of known drugs by finding new therapeutic targets; identification of the mechanism of toxicity of drug candidates or drugs which failed in the clinic; identification of new chemical tools for chemically-driven target validation; identification of new drug leads; and identification of the mechanism of action of drugs and drug candidates. A key advantage of the technology is that a single experiment can identify the numerous proteins which interact with a probe (or “bait”).Type: ApplicationFiled: February 3, 2003Publication date: September 4, 2003Applicant: MDS Proteomics Inc.Inventors: Shane Climie, Leroi Victor Desouza, Henry Duewel, Christopher Mark Hosfield, Linda Chiou-Lin Liao, Linda D. B. McBroom, Irving Sucholeiki, Leticia M. Toledo-Sherman
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Publication number: 20020132120Abstract: A composite paramagnetic particle and method of making are provided. In one aspect of the invention, a particle comprising a multitude of submicron polymer bead aggregates covalently cross-linked to each other to form larger diameter particles is presented. Distributed throughout the composite paramagnetic particle are vacuous cavities. Each submicron polymer bead has distributed throughout its interior and surface submicron magnetite crystals. In another aspect of the invention, composite particles are made using high energy ultrasound during polymerization of one or more vinyl monomers. In one embodiment, high energy ultrasound is used during an emulsification step and during the early stages of the polymerization process to produce micron sized composite paramagnetic particles. The particles according to the invention exhibit a high percent magnetite incorporation and water and organic solvent stability.Type: ApplicationFiled: May 14, 2002Publication date: September 19, 2002Applicant: MDS Proteomics, Inc.Inventors: Irving Sucholeiki, Nak-Ho Sung, Jun Young Lee
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Patent number: 6423410Abstract: A composite paramagnetic particle and method of making are provided. In one aspect of the invention, a particle comprising a multitude of submicron polymer bead aggregates covalently cross-linked to each other to form larger diameter particles is presented. Distributed throughout the composite paramagnetic particle are vacuous cavities. Each submicron polymer bead has distributed throughout its interior and surface submicron magnetite crystals. In another aspect of the invention, composite particles are made using high energy ultrasound during polymerization of one or more vinyl monomers. In one embodiment, high energy ultrasound is used during an emulsification step and during the early stages of the polymerization process to produce micron sized composite paramagnetic particles. The particles according to the invention exhibit a high percent magnetite incorporation and water and organic solvent stability.Type: GrantFiled: August 2, 1999Date of Patent: July 23, 2002Assignee: MDS Proteomics, Inc.Inventors: Irving Sucholeiki, Nak-Ho Sung, Jun Young Lee