Patents Assigned to MDV Technologies, Inc.
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Patent number: 6436425Abstract: Non-gelling polyoxyalkylene compositions, and methods of their use for inhibiting surgical adhesion formation/reformation in mammals are disclosed. The useful non-gelling compositions preferably comprise polyoxyalkylene block copolymer at desired concentrations with or without a therapeutic agent. When used with an incorporated drug, the non-gelling compositions serve as a carrier providing sustained or prolonged release of the therapeutic agent.Type: GrantFiled: February 8, 2000Date of Patent: August 20, 2002Assignee: MDV Technologies, Inc.Inventors: Raymond L. Henry, Lorraine E. Reeve, Stephen G. Flore, Frederick J. Foley
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Patent number: 6399624Abstract: A method and compositions for reducing post-surgical adhesion formation/reformation in mammals following surgical injury to a body cavity or organs situated therein. The aqueous compositions comprising pentoxifylline and a polyoxyalkylene block copolymer are applied to the injured areas subsequent to surgical injury.Type: GrantFiled: March 1, 2000Date of Patent: June 4, 2002Assignee: MDV Technologies, Inc.Inventors: Lorraine E. Reeve, Stephen G. Flore
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Patent number: 6346272Abstract: Balanced pH, thermo-irreversible gels are ideal vehicles for drug delivery to a body cavity of a mammal. The gels contain a mixture of a polyoxyalkylene block copolymer or polyether together with an ionic polysaccharide which is thermo-irreversibly gelled in the presence of a counter-ion.Type: GrantFiled: August 7, 1997Date of Patent: February 12, 2002Assignee: MDV Technologies, Inc.Inventors: Tacey X. Viegas, Lorraine E. Reeve, Raymond L. Henry
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Patent number: 6136334Abstract: Balanced pH, hyperosmotic, hypoosmotic, or isoosmotic gels are ideal vehicles for drug delivery. They are especially suited for topical body cavity or injection application of drugs or diagnostic agents; for drug or diagnostic agent delivery to the eye of a mammal; as protective corneal shields; or as ablatable corneal masks useful in laser reprofiling of the cornea. The compositions without the addition of a drug or diagnostic agent are useful as medical devices, for instance, in separating surgically or otherwise injured tissue as a means of preventing adhesions.Type: GrantFiled: June 11, 1999Date of Patent: October 24, 2000Assignee: MDV Technologies, Inc.Inventors: Tacey X. Viegas, Lorraine E. Reeve, Raymond L. Henry
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Patent number: 6034088Abstract: A method and compositions for reducing post-surgical adhesion formation/reformation in mammals following surgical injury to a body cavity or organs situated therein. The aqueous compositions comprising pentoxifylline and a polyoxyalkylene block copolymer are applied to the injured areas subsequent to surgical injury.Type: GrantFiled: August 27, 1998Date of Patent: March 7, 2000Assignee: MDV Technologies, Inc.Inventors: Lorraine E. Reeve, Stephen G. Flore
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Patent number: 5958443Abstract: Balanced pH, hyperosmotic, hypoosmotic, or isoosmotic gels are ideal vehicles for drug delivery. They are especially suited for topical body cavity or injection application of drugs or diagnostic agents; for drug or diagnostic agent delivery to the eye of a mammal; as protective corneal shields; or as ablatable corneal masks useful in laser reprofiling of the cornea. The compositions without the addition of a drug or diagnostic agent are useful as medical devices, for instance, in separating surgically or otherwise injured tissue as a means of preventing adhesions.Type: GrantFiled: December 23, 1996Date of Patent: September 28, 1999Assignee: MDV Technologies, Inc.Inventors: Tacey X. Viegas, Lorraine E. Reeve, Raymond L. Henry
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Patent number: 5847023Abstract: Balanced pH, thermo-irreversible gels comprising a polyoxyalkylene compound and an ionic polysaccharide are ideal materials for the formation of a protective contact lens over the cornea of the eye of a mammal.Type: GrantFiled: November 3, 1995Date of Patent: December 8, 1998Assignee: MDV Technologies, Inc.Inventors: Tacey X. Viegas, Lorraine E. Reeve, Raymond L. Henry
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Patent number: 5843470Abstract: A method and compositions for reducing post-surgical adhesion formation/reformation in mammals following surgical injury to a body cavity or organs situated therein. The aqueous compositions comprising pentoxifylline and a polyoxyalkylene block copolymer are applied to the injured areas subsequent to surgical injury.Type: GrantFiled: October 6, 1995Date of Patent: December 1, 1998Assignee: MDV Technologies, Inc.Inventors: Lorraine E. Reeve, Stephen G. Flore
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Patent number: 5800711Abstract: A process for the fractionation of polyoxyalkylene block copolymers wherein the polydispersity of the polyether is reduced. The fractionation process, which removes lower molecular weight species such as polyoxyalkylene homopolymer, truncated polyoxyalkylene diblock polymers, or other reaction byproducts, comprises salt extraction and liquid phase separation to provide a product with a narrower molecular weight distribution, lower degree of unsaturation, and distinctly different physical characteristics compared to the starting material.Type: GrantFiled: October 18, 1996Date of Patent: September 1, 1998Assignee: MDV Technologies, Inc.Inventors: Lorraine E. Reeve, Michael G. Hinsberg
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Patent number: 5681576Abstract: A process and compositions for reducing post-surgical adhesion formation/reformation in mammals following injury to organs situated in mammalian body spaces. Aqueous, isotonic gel compositions, preferably at mammalian body fluid pH, comprising a polyoxyalkylene polymer are applied to injured areas of the organs situated in body cavities such as, the peritoneal, pelvic, or pleural cavity.Type: GrantFiled: February 9, 1996Date of Patent: October 28, 1997Assignee: MDV Technologies, Inc.Inventor: Raymond L. Henry
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Patent number: 5593683Abstract: Compositions based upon aqueous gels for medical application, comprising polyoxyalkylene copolymers. Such gels which are isotonic, iso-osmotic, pH balanced, thermo-reversible gels are ideal vehicles for drug or diagnostic agent delivery.Type: GrantFiled: March 3, 1994Date of Patent: January 14, 1997Assignee: MDV Technologies, Inc.Inventors: Tacey X. Viegas, Lorraine E. Reeve, Raymond L. Henry
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Patent number: 5587175Abstract: Balanced pH, hyperosmotic, hypoosmotic, or isoosmotic gels are ideal vehicles for drug delivery. They are especially suited for topical body cavity or injection application of drugs or diagnostic agents; for drug or diagnostic agent delivery to the eye of a mammal; as protective corneal shields; or as ablatable corneal masks useful in laser reprofiling of the cornea. The compositions without the addition of a drug or diagnostic agent are useful as medical devices, for instance, in separating surgically or otherwise injured tissue as a means of preventing adhesions.Type: GrantFiled: December 28, 1993Date of Patent: December 24, 1996Assignee: MDV Technologies, Inc.Inventors: Tacey X. Viegas, Lorraine E. Reeve, Raymond L. Henry