Patents Assigned to Mead Johnson & Company
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Patent number: 4206142Abstract: Styrylamidines are prepared by treating styrylsulfonylamidines with base. The styrylamidines are effective in the prevention of aggregation of blood platelets and as analgesics. Compounds of the invention are also useful as anticonvulsants, diuretics, and antihypertensive agents. The styrylsulfonylamidines of the invention which serve as precursors to the styrylamidines also have analgesic properties. Illustrative of the styrylamidines of the present invention are 4-amino-N-(4-aminostyryl)benzamidine and N-(3,4-dichlorostyryl)acetamidine. An example of a styrylsulfonylamidine is N-(styrylsulfonyl)acetamidine.Type: GrantFiled: October 6, 1978Date of Patent: June 3, 1980Assignee: Mead Johnson & CompanyInventors: William L. Matier, William T. Comer
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Patent number: 4196212Abstract: N-Phenyl amidines which have diuretic, antithrombogenic, smooth muscle relaxant, anti-inflammatory and antiarrhythmic properties have been discovered. They are prepared by reacting a substituted aniline with a carboxamide selected from the group consisting of amides and lactams in the presence of phosphorus oxychloride. Typical examples of substituted N-phenyl amidines thus obtained are 5-methyl-2-(N-phenylbenzylamino)-1-pyrroline, 2-(N-phenylbenzylamino)-1-pyrroline, 3-[(N-1-pyrrolin-]-yl-p-anisidino)methyl]indole and 4,5,6,7,8,9-hexahydro-2-(N-phenylphenethylamino)-3H-azonine. Indole substituted N-phenyl amidines can be rearranged to provide iminopyrrolinidinyl-indoles which are useful as diuretic, antithrombogenic and smooth muscle relaxant agents. In the case of 3-[(N-1-pyrrolin-2-yl-p-anisidino)methyl]indole, the rearranged product is 3-[[2-(p-methoxyphenylimino)-1-pyrrolidinyl]methyl]indole.Type: GrantFiled: July 25, 1977Date of Patent: April 1, 1980Assignee: Mead Johnson & CompanyInventors: Yao H. Wu, Walter G. Lobeck, Jr.
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Patent number: 4186131Abstract: 1-Secondary-amino-3-(1-phenyl and substituted phenyl-5-tetrazolyloxy)-2-propanols are new compounds which are useful as cardiovascular agents having antiarrhythmic and .beta.-adrenergic blocking actions.Type: GrantFiled: March 24, 1978Date of Patent: January 29, 1980Assignee: Mead Johnson & CompanyInventors: William E. Kreighbaum, William T. Comer
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Patent number: 4182888Abstract: A series of 2,6-diamino-4-tertiary-amino-pyridine 1-oxides is disclosed. Substituents in the 4-position include diethylamino, pyrrolidinyl, piperidino, morpholino, thiomorpholino, and N-methylpiperazino. Novel oxadiazolones such as 5-amino-7-(1-piperidinyl)-2H-[1,2,4]-oxadiazolo[2,3-a]pyridine-2-one which are useful in the preparation of the pyridine 1-oxides are also disclosed. The compounds of this invention lower blood pressure in normotensive and hypertensive mammals and are particularly useful in the treatment of hypertensive conditions in mammals. 2,6-Diamino-4-(1-piperidinyl)pyridine 1-oxides is a prepresentative embodiment of the invention.Type: GrantFiled: January 30, 1978Date of Patent: January 8, 1980Assignee: Mead Johnson & CompanyInventors: John E. Lawson, Ronald D. Dennis
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Patent number: 4182763Abstract: Buspirone hydrochloride is an effective anti-anxiety agent for the palliative treatment of neurotic patients in which symptoms of anxiety are predominant at doses which are without observable effect in either normal individuals or psychotic patients.Type: GrantFiled: May 22, 1978Date of Patent: January 8, 1980Assignee: Mead Johnson & CompanyInventors: George P. Casten, Gordon R. McKinney, Roger E. Newton, E. Crosby Tompkins, John H. Weikel, Jr.
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Patent number: 4178301Abstract: A mucolytic process is disclosed which comprises contacting N-(2-hydroxyethyl)mercaptoacetamidobenzamides or mercaptoacylamidobenzoic acids, mercaptoacetylsulfanilic acids and alkanoylthio derivatives thereof with mucus. Illustrative of compounds useful in the mucolytic process of the present invention are 4-(2-mercaptoacetamido)benzoic acid and N-(2-mercaptoacetyl)sulfanilic acid.Type: GrantFiled: October 16, 1978Date of Patent: December 11, 1979Assignee: Mead Johnson & CompanyInventors: Tellis A. Martin, William T. Comer
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Patent number: 4159377Abstract: 2-Aminothiophene-3-carboxamides are converted to oxamates or fumaramides by acylation of the amino group. Cyclization yields thieno[2,3-d]pyrimidines which may also be prepared from the corresponding oxazines. Compounds illustrative of those having inhibitory action on the immediate hypersensitivity reaction in mammals are N-[3-(aminocarbonyl)-4,5,6,7-tetrahydrobenzo[b]thien-2-yl]oxamic acid, ethyl 5,6,7,8-tetrahydro-4-oxo-4H-benzothieno[2,3-d][1,3]oxazine-2-carboxylate, and ethyl 3,4-dihydro-6-ethyl-4-oxothieno[2,3-d]pyrimidine-2-carboxylate.Type: GrantFiled: August 22, 1977Date of Patent: June 26, 1979Assignee: Mead Johnson & CompanyInventor: Davis L. Temple, Jr.
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Patent number: 4148908Abstract: Preparation of cyanomethylphenethanolamines useful as adrenergic stimulants is described. Preferred compounds such as 2-hydroxy-5-[1-hydroxy-2-[(1,1-dimethyl-2-phenylethyl)amino]ethyl]-benzene acetonitrile are selective beta-adrenergic stimulants having relatively greater potency on respiratory smooth muscle than on cardiac muscle. Such compounds are particularly valuable in the treatment of bronchial conditions.Type: GrantFiled: September 22, 1977Date of Patent: April 10, 1979Assignee: Mead Johnson & CompanyInventors: William E. Kreighbaum, William L. Matier, Herbert R. Roth
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Patent number: 4147805Abstract: A new class of alkylthiophenoxyalkylamine derivatives and methods for preparation are described. The compounds have vasodilating and antispasmodic activity, inhibit blood platelet aggregation and are substantially free of beta-adrenergic blocking effects. They are particularly valuable in the treatment of disease states responsive to vasodilation such as obstructive peripheral vascular diseases and cerebral vascular deficiencies. Representative and preferred embodiments of the invention are N-[3-[4-(methylthio)phenoxy]propyl]octylamine and N-[3-[4-(1-methylethyl)thio]phenoxy]-propyl]octylamine.Type: GrantFiled: July 28, 1978Date of Patent: April 3, 1979Assignee: Mead Johnson & CompanyInventor: Duane F. Morrow
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Patent number: 4140756Abstract: A tablet for controlled release of a water soluble medicament or dietary supplement is comprised of a water insoluble wax-like matrix core containing the water soluble medicament and coated with a permeable erosion resistant polymeric film. The core constitutes 95% or more of the tablet weight.Type: GrantFiled: October 18, 1977Date of Patent: February 20, 1979Assignee: Mead Johnson & CompanyInventor: Claude E. Gallian
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Patent number: 4132802Abstract: A mucolytic process is disclosed which comprises contacting N-(2-hydroxyethyl)mercaptoacetamidobenzamides or mercaptoacylamidobenzoic acids, mercaptoacetylsulfanilic acids and alkanoylthio derivatives thereof with mucus. Illustrative of compounds useful in the mucolytic process of the present invention are 4-(2-mercaptoacetamido)benzoic acid and N-(2-mercaptoacetyl)sulfanilic acid.Type: GrantFiled: March 24, 1978Date of Patent: January 2, 1979Assignee: Mead Johnson & CompanyInventors: Tellis A. Martin, William T. Comer
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Patent number: 4132794Abstract: Novel 10-imidoylphenoxazines and 10-imidoylacridans are prepared by reacting a phenoxazine or acridan having optional substituents selected from the group consisting of trifluoromethyl, halogen, dihalogen, alkyl or alkoxy with an imidoyl halide prepared in situ from amides and lactams. Illustrative embodiments are 10-(5-methyl-1-pyrrolin-2-yl)phenoxazine and 9,9-dimethyl-10-(5-methyl-1-pyrrolin-2-yl)acridan. The imidoylphenoxazines and imidoylacridan products are generally useful as smooth muscle relaxants.Type: GrantFiled: April 6, 1978Date of Patent: January 2, 1979Assignee: Mead Johnson & CompanyInventors: Yao H. Wu, Walter G. Lobeck, Jr.
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Patent number: 4132803Abstract: N-[3-(mercaptoacetylamino)benzoyl]glycine, alkali metal and amine salts thereof are potent topically effective mucolytic agents.Type: GrantFiled: March 24, 1978Date of Patent: January 2, 1979Assignee: Mead Johnson & CompanyInventor: Tellis A. Martin
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Patent number: 4130663Abstract: Styrylamidines are prepared by treating styrylsulfonylamidines with base. The styrylamidines are effective in the prevention of aggregation of blood platelets and as analgesics. Compounds of the invention are also useful as anticonvulsants, diuretics, and antihypertensive agents. The styrylsulfonylamidines of the invention which serve as precursors to the styrylamidines also have analgesic properties. Illustrative of the styrylamidines of the present invention are 4-amino-N-(4-aminostyryl)benzamidine and N-(3,4-dichlorostyryl)acetamidine. An example of a styrylsulfonylamidine is N-(styrylsulfonyl)acetamidine.Type: GrantFiled: April 10, 1978Date of Patent: December 19, 1978Assignee: Mead Johnson & CompanyInventors: William L. Matier, William T. Comer
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Patent number: 4119729Abstract: A new class of phenoxypropanolamine alkylsulfonyl derivatives and methods for their preparation are described. The new compounds possess antiarrhythmic and/or cardioselective .beta.-adrenergic blocking properties and are useful in the treatment of hypertension. Representative embodiments of the invention are 1-(isopropylamino)-3-[4-(methylsulfonyl)-m-tolyloxy]-2-propanol and 3-[4-(methylsulfonyl)-m-tolyloxy]-1-(1-phenoxy-2-propylamino)-2-propanol, the latter compound is particularly outstanding as an antihypertensive.Type: GrantFiled: October 27, 1977Date of Patent: October 10, 1978Assignee: Mead Johnson & CompanyInventors: William T. Comer, William E. Kreighbaum
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Patent number: 4115571Abstract: Novel amidine compounds selected from the group consisting of bis-pyrrolinyl derivatives of phenothiazines, phenoxazines and acridans are obtained by reacting a phenothiazine, phenoxazine or acridan with a pyrrolidinone in the presence of phosphorus oxychloride. The phenothiazine, phenoxazine, or acridan can also be alkylated with 2-chloro-1-(1-pyrrolin-2-yl)-2-pyrroline to provide compounds of the invention. Typical examples of bis-pyrrolinyl derivatives are 2-methoxy-10-[5-methyl-1-(5-methyl-1-pyrrolinyl-2-yl)-2-pyrrolin-2-yl]-phe nothiazine, 10-[1-(1-pyrrolin-2-yl)-2-pyrrolin-2-yl]phenoxazine, and 9,9-dimethyl-10-[5-methyl-1-(5-methyl-1-pyrrolin-2-yl)-2-pyrrolin-2-yl]acr idan. The amidine compounds are useful as diuretics, smooth muscle relaxants and antithrombogenic agents.Type: GrantFiled: January 13, 1978Date of Patent: September 19, 1978Assignee: Mead Johnson & CompanyInventors: Yao Hua Wu, Walter G. Lobeck, Jr.
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Patent number: 4096183Abstract: Styrylamidines are prepared by treating styrylsulfonylamidines with base. The styrylamidines are effective in the prevention of aggregation of blood platelets and as analgesics. Compounds of the invention are also useful as anticonvulsants, diuretics and antihypertensive agents. The styrylsulfonylamidines of the invention which serve as precursors to the styrylamidines also have analgesic properties. Illustrative of the styrylamidines of the present invention are 4-amino-N-(4-aminostyryl)benzamidine and N-(3,4-dichlorostyryl)acetamidine. An example of a styrylsulfonylamidine is N-(styrylsulfonyl)acetamidine.Type: GrantFiled: August 19, 1977Date of Patent: June 20, 1978Assignee: Mead Johnson & CompanyInventors: William L. Matier, William T. Comer
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Patent number: 4096277Abstract: A mucolytic process is disclosed which comprises contacting N-(2-hydroxyethyl)mercaptoacetamidobenzamides or mercaptoacylamidobenzoic acids, mercaptoacetylsulfanilic acids and alkanoylthio derivatives thereof with mucus. Illustrative of compounds useful in the mucolytic process of the present invention are 4-(2-mercaptoacetamido)-benzoic acid and N-(2-mercaptoacetyl)sulfanilic acid.Type: GrantFiled: October 18, 1976Date of Patent: June 20, 1978Assignee: Mead Johnson & CompanyInventors: Tellis Alexander Martin, William Timmey Comer
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Patent number: 4094981Abstract: Novel 10-imidoylphenoxazines and 10-imidoylacridans are prepared by reacting a phenoxazine or acridan having optional substituents selected from the group consisting of trifluoromethyl, halogen, dihalogen, alkyl or alkoxy with an imidoyl halide prepared in situ from amides and lactams. Illustrative embodiments are 10-(5-methyl-1-pyrrolin-2-yl)phenoxazine and 9,9-dimethyl-10-(5-methyl-1-pyrrolin-2-yl)acridan. The imidoylphenoxazines and imidoylacridan products are generally useful as smooth muscle relaxants.Type: GrantFiled: July 1, 1977Date of Patent: June 13, 1978Assignee: Mead Johnson & CompanyInventors: Yao Hua Wu, Walter G. Lobeck, Jr.
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Patent number: RE29875Abstract: A bronchodilator expectorant composition containing a sympathomimetic amine bronchodilator, the xanthine bronchodilator theophylline, guaiacol or a water soluble form thereof and a sedative.Type: GrantFiled: October 31, 1977Date of Patent: January 2, 1979Assignee: Mead Johnson & CompanyInventors: Neil H. Mercer, Hugh D. Bryan