Abstract: A process is described for the preparation of freeze-dried pharmaceutical compositions of mitomycin C, which are characterized by high stability and can be rapidly reconstituted to form solutions.

Abstract: A transfer device (10) for removing or transferring a medium out of or into a bottle (20) having a bottle neck (34) that can be closed by means of a closure (42), including a first adapter part (12), which can be positioned on the bottle, and a second adapter part (14), which interacts with the first adapter part, which can be displaced in the longitudinal direction of the bottle, and has a conducting element (50) for piercing the closure. After the second adapter part (14) has been displaced along the first adapter part in the direction of the closure (42) and the second adapter part has been locked, the first adapter part (12) is non-releasably fastened to or around the bottle (20).

Abstract: A transfer device (10) for removing or transferring a medium out of or into a bottle (20) having a bottle neck (34) that can be closed by means of a closure (42), including a first adapter part (12), which can be positioned on the bottle, and a second adapter part (14), which interacts with the first adapter part, which can be displaced in the longitudinal direction of the bottle, and has a conducting element (50) for piercing the closure. After the second adapter part (14) has been displaced along the first adapter part in the direction of the closure (42) and the second adapter part has been locked, the first adapter part (12) is non-releasably fastened to or around the bottle (20).

Abstract: A process is described for the preparation of freeze-dried pharmaceutical compositions of mitomycin C, which are characterized by high stability and can be rapidly reconstituted to form solutions.

Abstract: A method for purifying epidaunorubicin is provided. The purification method involves the removal of the impurity epi-feudomycin, which is formed as a by-product in the biotechnological production of epidaunorubicin.

Abstract: The invention relates to a transfer device for tapping or delivering a fluid from a bottle sealed with a closure, the device having a hollow cylinder-shaped first part having a circumferential wall, which first part can be placed on the bottle and surrounds the closure, a hollow cylinder-shaped second part which can be adjusted with respect to the first part, the second part having a first wall running transverse to the longitudinal axis direction, and a puncturing needle originating from the first wall and extending in the direction of the first part permitting piercing of the closure, wherein the first part cannot be adjusted axially with respect to the second part if the closure is not surrounded and, if the first part surrounds the closure, the first part can be adjusted with respect to the second part for piercing the closure.

Abstract: A crystalline epirubicin hydrochloride and a method for its production are provided. The method for producing the crystalline epirubicin hydrochloride includes the steps: (a) providing epirubicin hydrochloride, (b) producing a mixture containing the provided epirubicin hydrochloride and at least one alcohol selected from the group 1-butanol, 2-butanol, and 1-pentanol, and (c) crystallizing epirubicin hydrochloride from this mixture.

Abstract: A method for purifying epidaunorubicin is provided. The purification method involves the removal of the impurity epi-feudomycin, which is formed as a by-product in the biotechnological production of epidaunorubicin.

Abstract: 4?-epidaunorubicin hydrochloride is provided in a crystalline form which is stable and readily soluble. A process of producing the crystalline form includes crystallizing 4?-epidaunorubicin hydrochloride in a solvent system including (a) solvent A selected from C1 and C2 halogenated solvents and mixtures thereof, (b) solvent B selected from C1-C5 straight and branched alcohols and mixtures thereof, and (c) solvent C selected from C1-C5 straight and branched alcohols and mixtures thereof, wherein solvent C is selected to provide lower solubility to 4?-epidaunorubicin hydrochloride than solvent B. A method of producing an anthracycline using crystalline 4?-epidaunorubicin hydrochloride is also provided.

Abstract: The invention relates to the use of treosulfan and/or derivatives thereof for producing a pharmaceutical composition used in the treatment of multiple sclerosis.

Abstract: The invention relates to the use of treosulfan as a conditioning agent before allogenic transplantation of bone marrow or haematopoietic stem cells, whereby treosulfan is administered, either as single effective agent, or in combination with other chemotherapetic agents or immunosuppressant agents.

Abstract: Provided is a drug carrier comprising particles of at least one pure active compound which is insoluble, only sparingly soluble or moderately soluble in water, aqueous media and/or organic solvents, wherein said active ingredient is solid at room temperature and has an average diameter, determined by photon correlation spectroscopy (PCS) of 10 nm to 1,000 nm, the proportion of particles larger than 5 .mu.m in the total population being less than 0.1% (number distribution determined with a Coulter counter), and, when introduced into water, aqueous media and/or organic solvents, the active compound has an increased saturation solubility and an increased rate of dissolution compared with powders of the active compound prepared using an ultrasonic probe, a ball mill or a pearl mill, the solid particles having been comminuted, without prior conversion into a melt, by using cavitation or shearing and impact forces with introduction of a high amount of energy.

Abstract: The invention relates to recombinant staphylokinase polypeptides with plasminogen activator effect and to their production and use. The polypeptides are obtained by expression of DNA sequences which are free from signal-peptide-coding regions.

Abstract: An artificial, triple-lobed semilunar valve is disclosed for replacing the aortic or pulmonary valve in the heart. The valve includes a flexible suture ring which conforms to the shape of the aortic root and three flexible pockets which are mounted within the suture ring. When fluid flows through the suture ring in one direction, the pockets bend outwards to the vessel wall and lie free-floating in the fluid, thereby permitting fluid to flow through the valve. However, when the fluid begins to flow in the opposite direction, the pockets open and contact one another to close the valve thereby preventing fluid flow in the opposite direction.

Abstract: A pump assembly is disclosed which includes a pump which is externally controlled to vary with time the volume and/or the pressure of fluid pumped therethrough. A memory unit is programmed to provide a desired volume-time and/or pressure-time characteristic. The output of the memory is utilized to drive the pump to provide the aforementioned pump characteristics. Provision is made for appropriately modifying the stored program in accordance with preselected parameters so that the pump can, for example, operate in conjunction with an artificial heart.

Abstract: A chamber and process for performing the electroimmunomigration step (the second phase of a crossed-electrophoresis process) for separating protein-containing biological fluids. The chamber preferably includes a base plate having a well defined therein, a depot subdividing the well into migration and connecting wells, and a device for defining a vertically variable gap in the depot so that a first carrier having a protein-containing sample in the depot is in contact with a second carrier in the migratory well and/or connecting well. Various devices may be provided for particularly defining the gap, and for defining the depot and the areas of the wells adjacent the depot.