Abstract: The invention relates to an application system for the transepidermal surface administration of medications, said system comprising a container (1) accommodating a sprayable, active agent-containing composition, a propellant gas source (3) for pressurized gas consisting of at least 25% v/v of oxygen, and a spraying device (2), wherein container (1), propellant gas source (3), and spraying device (2) are flow-connected with each other in such a manner that the propellant gas atomizes the sprayable composition and, when the spraying device (2) is actuated, forces it out of the spraying device (2), with the composition being forced out of the spraying device (2) in the form of a conical spray jet at an exit velocity of ?100 m/s. With the help of the inventive application system active agents can be effectively administered via the skin without causing injury to the skin. As a result of the high exit velocity the penetration rate is especially favorable even when larger molecules are introduced.

Abstract: The invention relates to an application system provided with a micro emulsion (14) containing a medication, said micro emulsion being contained in a medicament reservoir (12), a first gas connection (18) to which oxygen can be guided, a nozzle head (28) comprising recesses (29) which are arranged on the end of the medicament reservoir (12) and an atomising nozzle (30) which is arranged in the nozzle head (28). Pressure exerted on the microemulsion for atomising as well as the microemulsion emerging therefrom atomises the oxygen into drops by means of a Venturi arrangement in the atomising nozzle (30).