Abstract: The invention relates to novel arylamide derivatives having formula (I) and stereoisomers and pharmaceutically acceptable salts thereof, where R1-R11, R?, R?, z and X are as defined in the claims. The arylamide derivatives of formula (I) have antiandrogenic properties. The invention also relates to compounds of formula (I) for use as a medicament and to pharmaceutical compositions comprising them and to their preparation.
Type:
Grant
Filed:
July 14, 2011
Date of Patent:
August 26, 2014
Assignee:
Medeia Therapeutics Ltd
Inventors:
Jari Ratilainen, Milla Koistinaho, Anu Muona
Abstract: The invention relates to novel arylamide derivatives having formula (I) and stereoisomers and pharmaceutically acceptable salts thereof, where R1-R11, R?, R?, z and X are as defined in the claims. The arylamide derivatives of formula (I) have antiandrogenic properties. The invention also relates to compounds of formula (I) for use as a medicament and to pharmaceutical compositions comprising them and to their preparation.
Type:
Application
Filed:
July 14, 2011
Publication date:
May 2, 2013
Applicant:
MEDEIA THERAPEUTICS LTD
Inventors:
Jari Ratilainen, Milla Koistinaho, Anu Muona
Abstract: The current invention relates to methods for stimulating mammalian cells to enhance their ability to cross the blood-brain-barrier and to phagocytose and degrade beta-amyloid plaques in the brain. The current invention also relates to cells obtained by the method of the invention. The current invention also relates to methods for prevention and treatment of amyloid-accumulating disorders.