Abstract: An apparatus for determining a polarization-insensitive interferometric signal and a birefringence for a sample and methods for using such an apparatus to characterize the sample are proved herein. Such apparatuses may generally be designed to eliminate birefringence associated with the apparatus itself, collect data from the sample using light in both orthogonal states, and determine the interference birefringence associated with the collected data.

Abstract: Interferometers and autocorrelator based sensors are disclosed that are configured to have multiple sample arms which can be scanned and the backscattered low coherence source light from a sample resolved in a single sweep of one or more variable delays of the sensor. Borescopes and catheters capable of scanning multiple sections or areas of materials and tissues using these sensors are described.

Abstract: Connectors and linking components for a guidewire probe having multiple optical emitting fibers and methods of making connectors and linking components for guidewire probes having multiple optical emitting fibers are described herein.

Abstract: A system and method which integrates a mirror at the fiber tip to the fiber tip and uses a tilted flat at the exit plane to prevent astigmatism caused by the cylindrical curvature of the fiber wall and minimize reflection.

Abstract: Interferometers and autocorrelator based sensors are disclosed that are configured to have multiple sample arms which can be scanned and the backscattered low coherence source light from a sample resolved in a single sweep of one or more variable delays of the sensor. Borescopes and catheters capable of scanning multiple sections or areas of materials and tissues using these sensors are described.

Abstract: A multi-channel low coherence interferometer having sensing and reference arms, at least one of which has variable delay. The sensing arm includes an optical switch for connecting to two or more probe arms. The distal ends of the probe arms collect source light backscattered from a sample. The backscattered light collected by the distal end of a probe arm is combined with reference light and a low coherence interferometric signal is produced by a sweep of a variable delay of the device or a sweep of a variable frequency laser light source. The interference signal produced by the interaction of reference and sensing light at a detector measures backscattered light, which may be used to characterize the sample. The low coherence interferometric signals can provide information about the morphology, physical nature, composition, and properties of the sample.

Abstract: A method for diagnosing a human condition from a characteristic of a plaque or tissue in a subject is presented. The method includes directing broadband light by means of a sensing light path at an area of interest in the subject, at a target depth defined by the sensing light path and a reference light path. The continues with receiving the broadband light reflected from the area of interest in the subject by means of the sensing light path. The method further includes directing the broadband light by means of the reference light path at a reflecting device, and receiving the broadband light reflected from the reflecting device by means of the reference light path.

Abstract: Interferometers and autocorrelator based sensors are disclosed that are configured to have multiple sample arms which can be scanned and the backscattered low coherence source light from a sample resolved in a single sweep of one or more variable delays of the sensor. Borescopes and catheters capable of scanning multiple sections or areas of materials and tissues using these sensors are described.

Abstract: A method for determining a characteristic of tissue in a biological sample comprising: directing light at the biological sample at a first depth and receiving that light reflected from the biological; directing the light at a reflecting device and receiving that light reflected from the reflecting device. The method also includes: interfering the light reflected from the biological sample and the light reflected from the reflecting device; detecting light resulting from the interfering; and determining a first phase associated with the light resulting from the interfering based on the first depth. The method further includes: varying an effective light path length to define a second depth; determining a second phase associated with the light resulting from the interfering based on the second depth; and determining the characteristic of the biological sample from the first phase and the second phase.

Abstract: A method and system for determining a characteristic of a biological sample including directing light at the biological sample and receiving that light; directing the light at a reference reflecting device and receiving that light; adjusting an effective light path length to facilitate an interference of the light reflected from the biological sample corresponding to a first depth and the light reflected from the reference reflecting device; and detecting the broadband light resulting from the interference, to provide an interference signal. The method also includes: determining a first phase associated with the interference signal corresponding to the first depth; varying the effective light path length to define a second depth; determining a second phase associated with the interference signal corresponding to the second depth; and determining the characteristic of the biological sample from the phases.

Abstract: A method for determining a characteristic of an analyte in a biological sample, the method comprising: directing broadband light by means of a sensing light path at the biological sample, at a target depth defined by the sensing light path and a reference light path; and receiving the broadband light reflected from the biological sample by means of the sensing light path. The method also includes: directing the broadband light by means of the reference light path at a reflecting device; receiving the broadband light reflected from the reflecting device by means of the reference light path; and interfering the broadband light reflected from the biological sample and the broadband light reflected from the reflecting device.