Abstract: A method for healing a hard-to-heal wound including the steps of: topically administering a wound healing composition to a wounded area, wherein the wound healing composition includes, at least one of: (a) a medicament characterized as a calcium channel blocker or pharmaceutically acceptable salts or solvates thereof; (b) a medicament characterized as an alpha-adrenergic antagonist or pharmaceutically acceptable salts or solvates thereof; (c) a medicament characterized as a direct vasodilator or pharmaceutically acceptable salts or solvates thereof; and (d) a medicament characterized as a phosphodiesterase type five inhibitor or pharmaceutically acceptable salts or solvates thereof; and (e) a hemorrheologic agent or pharmaceutically acceptable salts or solvates thereof; (f) a primary dermal penetrating agent or pharmaceutically acceptable salts or solvates thereof: and (g) a topical stimulating agent or pharmaceutically acceptable salts or solvates thereof.

Abstract: A system and methodology for treatment of circulation related conditions in hooved animals such as laminitis in horses. The methodology employs a garment wrap that is releasably secured to the animal's leg. The wrap includes several inflatable chambers, one of which, the most distal one, engages the frog and bulbar sections of the horses hoof. The methodology calls for the pressuring of the inflatable chambers in accordance with a sequence that prevents backflow from a more proximal point on the animal's leg to a more distal point on the leg. A boot arrangement including an inner sole pad are also utilized both during the therapy procedure and afterwards. The inner sole pad can provide related medications and can be used in an iontophoresis procedure.