Patents Assigned to Mederio AG
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Patent number: 7431916Abstract: A method of administering a metered dry powder combined dose of finely divided dry medication powders is disclosed, wherein said method comprises providing a relative motion between a nozzle of a dry powder inhaler and a dose bed carrying said combined dose of finely divided dry medication powder intended for delivery by the dry powder inhaler, the combined dose comprises metered quantities of at least two medicaments separately deposited on the dose bed, the relative motion causing the nozzle to pass over the combined dose for a simultaneous or sequential delivery of the medicaments during the course of a single suction of air.Type: GrantFiled: June 26, 2003Date of Patent: October 7, 2008Assignee: Mederio AGInventors: Thomas Nilsson, Mattias Myrman, Claes Friberg, Sven Calander
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Publication number: 20080202630Abstract: A method and an apparatus for exact metering and volumetric filling of dry powder medicament doses into preformed containers, which are adapted for administration by a dry powder inhaler. The filling apparatus includes at least a bulk powder source, a feeding chamber, and a receptacle providing the volume for a specified load mass of dry powder. The bulk powder source releases a portion of powder discontinuously to the feeding chamber, but is disconnected from the feeding chamber and receptacle during the filling operation. The filling apparatus further presents a plane surface in contact with the movable feeding chamber and provides a hard-wearing, low friction coating for reducing dynamic friction and powder retention.Type: ApplicationFiled: February 8, 2005Publication date: August 28, 2008Applicant: Mederio AGInventors: Lars Kax, Claes Friberg
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Publication number: 20080184998Abstract: An improved foil-cutting device is disclosed for opening a foil protecting a pre-metered dose of medication power carried by dose carrier to be used in an inhaler device. The dose carrier with the medication powder is covered by a seal, e.g. metallic or plastic foil. The foil-cutter device of the present invention provides a knife device tool for simultaneous access of a selected sealed dose of medication powder during an inhalation process using a dry powder inhaler (DPI).Type: ApplicationFiled: December 12, 2005Publication date: August 7, 2008Applicant: MEDERIO AGInventors: Mattias Myrman, Mats Eriksson
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Publication number: 20080023098Abstract: The invention discloses a method and a tool for exact metering and volumetric filling of finely divided dry powder medicament doses into preformed containers, whereby the doses and containers are adapted for administration by inhalation using a dry powder inhaler (DPI). A filling tool illustrating the invention includes at least one receptacle (10). The shape and size of a receptacle may vary depending on the size and mass of the powder load to be metered. A stretched woven filter (106) is positioned between the second opening of the receptacle (10) and a suction nozzle (13), using flexible seals at joints to stop air and powder leakage. The shape may be circular or elliptical, the wideness and depth, i.e. the volume, is adapted to the intended load and the method of filling and unloading.Type: ApplicationFiled: May 18, 2006Publication date: January 31, 2008Applicant: MEDERIO AGInventors: Claes Friberg, Lars Kax
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Patent number: 7278426Abstract: A method and a device for making a metered dry powder medication dose, enclosed in a dose container, accessible for inhalation with a minimum of exposure to ambient atmosphere.Type: GrantFiled: June 6, 2005Date of Patent: October 9, 2007Assignee: Mederio AGInventor: Mattias Myrman
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Publication number: 20070101991Abstract: A method based on an Air-razor tool is disclosed thereby providing improved release and dispersal into air of a dose of medication powder. When air is sucked through a suction tube, particles of a powder dose, made available to the suction tube, are gradually released and dispersed into a stream of air entering the suction tube. The gradual release and dispersal is produced by a relative motion introduced between the suction tube and the dose. The high velocity air going into the suction tube inlet provides plenty of shearing stress and inertia energy as the flowing air hits the leading point of the dose. This powder Air-razor method, created by the shearing stress and inertia of the air stream, is so powerful that the particles of the powder adjacent to the inlet of the moving suction tube are released and subsequently entrained in the air stream going through the suction tube.Type: ApplicationFiled: November 8, 2005Publication date: May 10, 2007Applicant: MEDERIO AGInventors: Mattias Myrman, Mats Eriksson
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Publication number: 20060239933Abstract: A medical product is disclosed. The medical product contains an accurately metered dose of at least one GLP medicament intended for pulmonary inhalation put into a moisture-tight, high barrier seal container. The medical product optionally also contains a dose of insulin. The container is adapted for application into a dry powder inhaler. The dose loaded in the container is intended for a prolonged delivery by inhalation to the deep lung where the active ingredients are absorbed into the system. Optionally the medical product also may comprise at least one biologically acceptable excipient.Type: ApplicationFiled: November 15, 2005Publication date: October 26, 2006Applicant: MEDERIO AGInventors: Thomas Nilsson, Sven Calander, Alf Niemi, Claes Friberg, Lars Kax, Mattias Myrman
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Patent number: 7069963Abstract: The invention discloses a method and a tool for exact metering and volumetric filling of finely divided dry powder medicament doses into preformed containers, whereby the doses and containers are adapted for administration by inhalation using a dry powder inhaler (DPI). A filling tool illustrating the invention includes at least one receptacle (10). The shape and size of a receptacle may vary depending on the size and mass of the powder load to be metered. A stretched woven filter (106) is positioned between the second opening of the receptacle (10) and a suction nozzle (13), using flexible seals at joints to stop air and powder leakage. The shape may be circular or elliptical, the wideness and depth, i.e. the volume, is adapted to the intended load and the method of filling and unloading.Type: GrantFiled: February 13, 2004Date of Patent: July 4, 2006Assignee: Mederio AGInventors: Claes Friberg, Lars Kax
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Publication number: 20060067911Abstract: The invention discloses a metered medication dose of a dry powder protein medicament, particularly a peptide medicament, intended for inhalation by use of an adapted dry powder inhaler. An active peptide agent is presented in a pure, natural, crystalline, micronized, dry powder form. A dose comprises at least one such peptide powder and may optionally comprise at least one biologically acceptable excipient in dry powder form. The dose does not include any substances that are intended to change one, some or all properties of the at least one peptide with an object of improving the stability or systemic absorption of the active peptide or peptides deposited.Type: ApplicationFiled: April 22, 2005Publication date: March 30, 2006Applicant: MEDERIO AGInventors: Thomas Nilsson, Claes Friberg, Lars Kax, Alf Niemi, Mattias Myrman, Sven Calander
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Publication number: 20060021616Abstract: A dry powder inhaler device (DPI) is disclosed. When a user activates the inhaler, the DPI is capable of delivering a dry powder dose directly from a medicament container, loaded into the DPI. A method is also disclosed for delivering a dry powder medicament dose directly from a container to a user of a DPI, whereby a sealing foil of the container is being slit open concurrently with aerosolizing and entraining of the powder in the dose into the inhaled air.Type: ApplicationFiled: June 6, 2005Publication date: February 2, 2006Applicant: MEDERIO AGInventor: Mattias Myrman
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Publication number: 20060005832Abstract: A medicament container for carrying a metered, finely divided, dry powder medication dose is disclosed. The medicament container, which is intended for administration by a dry powder inhaler device, constitutes a pod presents a bottom surface acting as a substrate adapted for receiving a metered medication dose. The metered dose, carried by the pod, is protected from foreign matter, particularly moisture, after a sealing of the pod with a high barrier seal foil, which transforms the pod into a high barrier container. Furthermore the pod is formed such that the pod sealing foil can be slit open from a point of penetration at a first pod end to a point of exit at a second pod end by a opener set in motion relative to the pod.Type: ApplicationFiled: June 17, 2005Publication date: January 12, 2006Applicant: MEDERIO AGInventors: Alf Niemi, Sven Calander, Lars Kax
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Publication number: 20060000473Abstract: A method and a device for making a metered dry powder medication dose, enclosed in a dose container, accessible for inhalation with a minimum of exposure to ambient atmosphere.Type: ApplicationFiled: June 6, 2005Publication date: January 5, 2006Applicant: MEDERIO AGInventor: Mattias Myrman
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Publication number: 20050287078Abstract: The invention relates to a method for improving the powder output, i.e. the emitted medication dose, from a dry powder inhaler device by minimizing the powder retention inside the device. Also therapeutic efficacy of the metered medication dose is hereby improved. It is found that adding a smaller amount of excipient than would be necessary in an ordered mixture, to a metered dose of an API formulation raises the emitted API dose when the dose is inhaled together with the excipient.Type: ApplicationFiled: June 17, 2005Publication date: December 29, 2005Applicant: MEDERIO AGInventors: Alf Niemi, Sven Calander, Lars Kax
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Publication number: 20050211244Abstract: A dry powder medicament preparation is disclosed. Also methods of forming and loading metered doses of the preparation into dose containers intended for insertion into a dry powder inhaler are disclosed. The preparation is adapted for a dose forming process, which may be based on volumetric filling or electro-dynamic deposition of the powder particles, such that a metered dose of the preparation is characterized by having at least one load of held-together particles joined in a macrostructure of predefined dimensions and presenting an intended mechanical strength. The pharmacologically active ingredient presents at least 50% by mass of particles in a typical aerodynamic diameter range from 1 to 5 ?m. Furthermore, a dose thus formed is then loaded into a high barrier container.Type: ApplicationFiled: March 22, 2005Publication date: September 29, 2005Applicant: MEDERIO AGInventors: Thomas Nilsson, Claes Friberg, Lars Kax, Alf Niemi, Sven Calander
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Patent number: 6892727Abstract: A device and an arrangement are disclosed, which create a powder Air-razor, which into an inhalation air volume de-aggregates and disperses a finely divided medication powder. The powder is generally loaded onto a dosing member intended for use with an inhaler. By sucking air through a mouthpiece connected to a nozzle, particles of the load of powder are gradually de-aggregated, dispersed and continuously released into the sucked air during a defined interval. The gradual de-aggregation and dispersal of the medication powder is generated by a relative motion introduced between the nozzle and the dosing member. The powder is generally loaded onto a larger area than the area of the air nozzle inlet. The nozzle may be positioned outside the dose area until an air stream has begun to flow into the nozzle by suction of air in an inhaling operation.Type: GrantFiled: April 30, 2002Date of Patent: May 17, 2005Assignee: Mederio AGInventor: Mattias Myrman