Patents Assigned to MEDEXGEN INCORPORATED
  • Non-diffusive botulinum toxin causing local muscle paralysis, and purification method thereof
    Patent number: 10369235
    Abstract: The present invention relates to a method for purifying a non-spreading botulinum toxin that causes local muscle paralysis and a non-spreading botulinum toxin obtained thereby. The method comprises the steps of: subjecting a purified botulinum toxin type A product to ion-exchange chromatography using a controlled pH of buffer, concentration of sodium chloride (NaCl), thereby separating the botulinum toxin type A product into subfractions; and collecting a subfraction having an A260/A280 value in a specific range from the separated subfractions.
    Type: Grant
    Filed: February 1, 2017
    Date of Patent: August 6, 2019
    Assignee: MEDEXGEN INCORPORATED
    Inventors: Yong Hoon Chung, Hyun Sub Lee
  • Non-diffusive botulinum toxin causing local muscle paralysis, and purification method thereof
    Patent number: 9598683
    Abstract: A method for purifying a non-spreading botulinum toxin that causes local muscle paralysis and a non-spreading botulinum toxin obtained thereby includes the steps of: subjecting a purified botulinum toxin type A product to ion-exchange chromatography using a controlled pH of buffer, concentration of sodium chloride (NaCl), thereby separating the botulinum toxin type A product into subfractions; and collecting a subfraction having an A260/A280 value in a specific range from the separated subfractions.
    Type: Grant
    Filed: May 13, 2011
    Date of Patent: March 21, 2017
    Assignee: MEDEXGEN INCORPORATED
    Inventors: Yong Hoon Chung, Hyun Sub Lee
  • NON-DIFFUSIVE BOTULINUM TOXIN CAUSING LOCAL MUSCLE PARALYSIS, AND PURIFICATION METHOD THEREOF
    Publication number: 20130071331
    Abstract: A method for purifying a non-spreading botulinum toxin that causes local muscle paralysis and a non-spreading botulinum toxin obtained thereby includes the steps of: subjecting a purified botulinum toxin type A product to ion-exchange chromatography using a controlled pH of buffer, concentration of sodium chloride (NaCl), thereby separating the botulinum toxin type A product into subfractions; and collecting a subfraction having an A260/A280 value in a specific range from the separated subfractions.
    Type: Application
    Filed: May 13, 2011
    Publication date: March 21, 2013
    Applicant: MEDEXGEN INCORPORATED
    Inventors: Yong Hoon Chung, Hyun Sub Lee