Abstract: The invention describes a method for identifying T-cell activating neo-epitopes from all genetically altered proteins. The mutated proteins contribute to neo-epitopes after they are proteolytically degraded within antigen presenting cells, such as dendritic cells and macrophages.
Type:
Grant
Filed:
October 23, 2017
Date of Patent:
July 16, 2019
Assignee:
MedGenome Inc.
Inventors:
Amitabha Chaudhuri, Ravi Gupta, Priyanka Shah, Malini Manoharan, Kiran V. Paul, Rohit Gupta