Abstract: A prophylactic spermicidal lubricant composition and method for its use in safe sexual relations, including prevention of infection by HIV and other viruses. The composition contains: a) a cosmetically acceptable lubricant effective to reduce friction, thereby reducing the rupture of blood vessels during sexual relations; b) an effective amount of chlorhexidine salt active against HIV and other, viruses, the chlorhexidine salt immobilizing sperm and reacting with vaginal mucosa to form a barrier to the penetration of sperm calls into the uterus, but also destroying natural flora in the vagina and thereby permitting growth of fungi which causes ulceration; and c) an effective amount of a cosmetically acceptable fungicide to prevent the growth of fungi in the vagina in the absence of natural bacterial flora, destroyed by the chlorhexidine salt.