Abstract: Allergens are contained in strictly controlled and reproducible amounts on solid supports to provide a progressive release of the allergen perlingually and sublingually. The compositions are prepared by dissolving an allergen in a polar solvent to obtain a mother solution; preparing dilutions of different predetermined concentrations; fractionating each of the dilutions into sub-dilutions; and impregnating a pharmaceutically acceptable solid support with each sub-dilution, each impregnation step being followed by drying in forced, dried air at a temperature not greater than 30.degree. C.; and applying a protective coating onto the composition.
Type:
Grant
Filed:
February 14, 1991
Date of Patent:
September 14, 1993
Assignee:
Medibrevex
Inventors:
Georges Bruttmann, Patrick Pedrali, Serge Robert
Abstract: New galenical forms for administering beta-2-mimetics comprising a support conditioned to be placed into the sublingual and perlingual cavity of the mouth, the support made of a pharmaceutically acceptable compound which disintegrates under the action of saliva and progressively releases a controlled amount of the beta-2-mimetics into the sublingual and perlingual cavity of the mouth.
Type:
Grant
Filed:
September 24, 1990
Date of Patent:
January 14, 1992
Assignee:
Societe Civile dite: "Medibrevex"
Inventors:
Josiane Ayache, Jean-Jacques Ayache, Georges Bruttmann, Patrick Pedrali, Serge Robert
Abstract: In these new galenical forms the corticoid is contained, in strictly controlled and reproducible amounts, in solid supports provided for an extended release of the active ingredient perlingually and sublingually.The corticoid is preferably methylprednisolone.The galenical forms can be prepared as follows:dissolving the corticoid in a solvent,preparing dilutions with different concentrations,fractionating each of these dilutions into subdilutions,impregnating by multi-impregnation or fractionated impregnation a pharmaceutically acceptable solid support with each of the subdilutions, each of said impregnation stages being followed by a drying in forced air dried at a temperature not more than 35.degree. C.
Type:
Grant
Filed:
October 7, 1988
Date of Patent:
October 29, 1991
Assignee:
Medibrevex
Inventors:
Josiane Ayache, Jean-Jacques Ayache, Georges Bruttmann, Patrick Pedrali, Serge Robert