Patents Assigned to Medical College of Georgia
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Publication number: 20110300241Abstract: Disclosed herein are oral care compositions for promoting salivary flow. Thus, also disclosed are methods of treating and preventing xerostomia. The oral care compositions can contain all-natural ingredients, including, for example, green tea polyphenols and jaborandi extract.Type: ApplicationFiled: February 22, 2010Publication date: December 8, 2011Applicant: Medical College of Georgia Research Institute, IncInventor: Stephen D. Hsu
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Publication number: 20110268710Abstract: A cell type that is a complete match of the transplant recipient appears as an optimal scenario to open treatment options to a large patient population with minimal complications. The use of autologous bone marrow or umbilical cord blood has been proposed as a good source of stem cells for cell therapy. Menstrual blood is found to be another important source of stem cells. Assays of cultured menstrual blood reveal that they express embryonic like-stem cell phenotypic markers and neuronal phenotypic markers under appropriate conditioned media. Oxygen glucose deprivation stroke models show that OGD-exposed primary rat neurons, co-cultured with menstrual blood-derived stem cells or exposed to the media from cultured menstrual blood, exhibited significantly reduced cell death.Type: ApplicationFiled: May 13, 2011Publication date: November 3, 2011Applicants: UNIVERSITY OF SOUTH FLORIDA, SANERON CCEL THERAPEUTICS, INC., MEDICAL COLLEGE OF GEORGIAInventors: Paul R. Sanberg, Cesario V. Borlongan, Julie Allickson
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Publication number: 20110245339Abstract: Prodrugs made up of biologically-active short-chain fatty acids or derivatives thereof conjugated to neutral or cationic amino acids capable of intracellular transport by ATB0,+ are provided. The short-chain fatty acid or derivative thereof can be attached to the amino acid through a hydroxyl group of the amino acid to form a fatty acid ester of the amino acid, or it can be attached through the amino group of the amino acid to form a fatty-acid amide of the amino acid. Serine butyrate (O-butyryl serine) is a preferred prodrug. These prodrugs are useful for treatment of colon cancer, inflammatory bowel disease, ulcerative colitis, Crohn's disease, lung cancer, cervical cancer, and cancers resulting from metastases from primary colon cancer sites. Methods of delivering biologically-active short-chain fatty acids or derivatives thereof to cells in need of these molecules and methods of treating diseases using the prodrugs of this invention are also provided.Type: ApplicationFiled: March 3, 2011Publication date: October 6, 2011Applicant: MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE, INCInventors: VADIVEL GANAPATHY, PUTTER D. PRASAD, ROBERT G. MARTINDALE
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Patent number: 7994784Abstract: A method for scaling MR signal intensity after noise has been removed is disclosed. Because the signal in a DTI series varies with the apparent diffusivity in the direction of an applied gradient, one can multiply image data collected under actual clinical conditions with a spatially-dependent scaling function to synthesize different spatial diffusion distributions, after removal of noise. Recombination of the data with the removed noise preserves the bias in the system.Type: GrantFiled: January 15, 2009Date of Patent: August 9, 2011Assignee: Medical College of Georgia Research Institute, Inc.Inventors: Nathan E. Yanasak, Tom C. Hu
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Patent number: 7938643Abstract: An illumination device including an integrating sphere and at least one light source. The integrating sphere is hollow and houses the at least one light source in it. The light source can be manipulated between a first configuration and a second configuration. The illumination device emits a first spectrum of light when the light source is in the first configuration, and a second spectrum of light when the light source is in the second configuration.Type: GrantFiled: January 23, 2008Date of Patent: May 10, 2011Assignee: Medical College of Georgia Research Institute, Inc.Inventor: Frederick A. Rueggeberg
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Patent number: 7888325Abstract: Introduction of double stranded RNA into cells, cell culture, organs and tissues, and whole organisms, particularly vertebrates, specifically attenuates gene expression.Type: GrantFiled: December 12, 2006Date of Patent: February 15, 2011Assignee: Medical College of Georgia Research Institute, Inc.Inventors: Yin-Xiong Li, Michael J. Farrell, Margaret J. Kirby
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Patent number: 7879791Abstract: A mechanism of macrophage-induced T cell suppression is the selective elimination of tryptophan and/or increase in one or more tryptophan metabolites within the local macrophage microenvironment. Studies demonstrate that expression of IDO can serve as a marker of suppression of T cell activation, and may play a significant role in allogeneic pregnancy and therefore other types of transplantation, and that inhibitors of IDO can be used to activate T cells and therefore enhance T cell activation when the T cells are suppressed by pregnancy, malignancy or a virus such as HIV. Inhibiting tryptophan degradation (and thereby increasing tryptophan concentration while decreasing tryptophan metabolite concentration), or supplementing tryptophan concentration, can therefore be used in addition to, or in place of, inhibitors of IDO.Type: GrantFiled: November 21, 2006Date of Patent: February 1, 2011Assignee: Medical College of Georgia Research Institute, Inc.Inventors: David Munn, Andrew Mellor
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Publication number: 20100324064Abstract: The present invention relates to novel analogs of choline and methods of use or treatment of neurodegenerative disorders and/or conditions such as Parkinson's disease, Huntington disease, Alzheimer's disease and related disorders such as amyotrophic lateral sclerosis, spinal muscular atrophy, Friedrich's ataxia, Pick's disease, Bassen-Kornzweig syndrome, Refsom's disease, retinal degeneration, Cruetzfelt-Jacob syndrome or prion disease (mad cow disease), dementia with Lewy bodies, schizophrenia, paraneoplastic cerebellar degeneration and neurodegenerative conditions caused by stroke. The present compounds are effective to treat any neurological condition where acetylcholine transmission neurons and their target cells are affected.Type: ApplicationFiled: July 22, 2010Publication date: December 23, 2010Applicants: Medical College of Georgia Research Institute, Universtiy of Georgia Research FoundationInventors: Jerry J. BUCCAFUSCO, Alvin V. Terry, J. Warren Beach, Rammamohanna R. Jonnala
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Publication number: 20100311804Abstract: The present invention provides improved treatment methods by the administration of both an inhibitor of indoleamine-2,3-dioxygenase in addition to the administration of an additional therapeutic agent.Type: ApplicationFiled: August 27, 2009Publication date: December 9, 2010Applicant: Medical College of Georgia Research Institute, Inc.Inventors: David MUNN, Andrew Mellor
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Patent number: 7847069Abstract: Antibodies selectively directed against SUM04 polypeptides are provided. The antibodies are useful research tools and further in the diagnosis and treatment of Type 1 diabetes.Type: GrantFiled: February 5, 2007Date of Patent: December 7, 2010Assignee: Medical College of Georgia Research InstituteInventors: Jin-Xiong She, Cong-Yi Wang
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Publication number: 20100260774Abstract: Methods and compositions for male or female contraception are provided. The compositions include an effective amount of netrin-1 to reduce or inhibit sperm concentration in semen of males or to inhibit or reduce fusion of male gametes with female gametes in a female subject Still another embodiment provides a method for diagnosing male infertility by determining the amount of netrin-1 in a sample of epididymal fluid or semen from a male subject, comparing the amount of netting-1 in the sample to levels of netrin-1 in samples of epididymal fluid or semen from fertile males, wherein levels of netrin-1 in the sample from the male subject that are higher or lower than levels of netrin-1 in samples from fertile males are indicative of male infertility in the male subject.Type: ApplicationFiled: November 3, 2008Publication date: October 14, 2010Applicant: MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE, INCInventors: Wen-Cheng Xiong, Jae-Ho Lee, Lin Mei
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Patent number: 7786147Abstract: The present invention relates to novel analogs of choline and methods of use or treatment of neurodegenerative disorders and/or conditions such as Parkinson's disease, Huntington disease, Alzheimer's disease and related disorders such as amyotrophic lateral sclerosis, spinal muscular atrophy, Friedrich's ataxia, Pick's disease, Bassen-Kornzweig syndrome, Refsom's disease, retinal degeneration, Cruetzfelt-Jacob syndrome or prion disease (mad cow disease), dementia with Lewy bodies, schizophrenia, paraneoplastic cerebellar degeneration and neurodegenerative conditions caused by stroke. The present compounds are effective to treat any neurological condition where acetylcholine transmission neurons and their target cells are affected.Type: GrantFiled: March 9, 2005Date of Patent: August 31, 2010Assignees: Medical College of Georgia Research Institute., University of Georgia Research Foundation, Inc.Inventors: Jerry J. Buccafusco, Alvin V. Terry, J. Warren Beach, Rammamohanna R. Jonnala
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Publication number: 20100212038Abstract: Disclosed are transgenic fish, and a method of making transgenic fish, which express transgenes in stable and predictable tissue- or developmentally-specific patterns. The transgenic fish contain transgene constructs with homologous expression sequences. Also disclosed are methods of using such transgenic fish. Such expression of transgenes allow the study of developmental processes, the relationship of cell lineages, the assessment of the effect of specific genes and compounds on the development or maintenance of specific tissues or cell lineages, and the maintenance of lines of fish bearing mutant genes.Type: ApplicationFiled: January 16, 2009Publication date: August 19, 2010Applicant: Medical College of Georgia Research Institute, Inc.Inventor: Shuo Lin
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Publication number: 20100200771Abstract: Improved radiation devices and their associated fabrication and applications are described herein. The microirradiators generally include a non-radioactive conducting electrode, an insulating sheath, a radioactive source, and, optionally, a contact electrode. The microirradiators generally produce low absolute radiation levels with high radiation flux densities.Type: ApplicationFiled: February 1, 2010Publication date: August 12, 2010Applicants: Georgia Tech Research Corporation, Medical College of Georgia Research InstituteInventors: Jiri Janata, Miroslava Josowicz, Jennifer Steeb, William S. Dynan, Wendy Kuhne
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Patent number: 7763251Abstract: The present invention is based on the discovery antigen-presenting cells (APCs) may be generated to have predetermined levels of expression of the intracellular enzyme, indoleamine 2,3-dioxygenase (IDO). Because expression of high levels of IDO is correlated with a reduced ability to stimulate T cell responses and an enhanced ability to induce immunologic tolerance, APCs having high levels of IDO may be used to increase tolerance in the immune system, as for example in transplant therapy or treatment of autoimmune disorders. Also disclosed are kits for assessing the relative risk of tumor progression in a subject. For example, disclosed are kits for assessing the relative risk of tumor progression in a subject and having reagents for detection of the enzyme indoleamine 2,3-dioxygenase (IDO) in a sample of tissue from a tumor or tumor draining lymph node from a subject, wherein the reagents are packaged in at least one individual container.Type: GrantFiled: June 23, 2006Date of Patent: July 27, 2010Assignee: Medical College of Georgia Research Institute, Inc.Inventors: Andrew L. Mellor, David H. Munn, Jeffrey Roberts Lee
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Patent number: 7732470Abstract: Derivative compounds of 11-nonyloxy-undec-8(Z)-eonic acid that mimic epoxide metabolites are provided. Also provided are compositions comprising a therapeutically effective amount of the derivative compounds. The present invention further provides methods for the use of such compositions for the treatment of renal or cardiovascular disease and/or related conditions.Type: GrantFiled: February 29, 2008Date of Patent: June 8, 2010Assignees: Medical College of Georgia Research Institute, Board of Regents, The University of Texas SystemInventors: John D. Imig, John R. Falck
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Publication number: 20100086618Abstract: Disclosed are systems, methods, compositions and kits for mineralizing tissue, particularly dental tissue. The methods, compositions and kits may be used to strengthen and prevent weakening of the tissue. For example, the methods, compositions and kits may be used for treating and filling cavities in teeth caused by tooth decay.Type: ApplicationFiled: October 8, 2009Publication date: April 8, 2010Applicant: Medical College of Georgia Research Institute, IncInventors: David Henry Pashley, Franklin Chi-Meng Tay
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Publication number: 20090312778Abstract: A surgical extractor including an elongated body having a handle and working tool coupled thereto. The extractor also includes at least one user operated button and at least one blade mechanically linked to the button. The blade is selectively movable between a retracted position and a deployed position. The blade is substantially contained within the body when in the retracted position, and it is substantially projected beyond the body when in the deployed position.Type: ApplicationFiled: June 15, 2009Publication date: December 17, 2009Applicant: MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE, INC.Inventor: Cargill H. ALLEYNE
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Publication number: 20090267603Abstract: A method for synthesizing crossing ADC distributions via reassembly of multiple k-spaces is disclosed. The method includes the steps of scanning a test object having a plurality of anisotropic structures to acquire a first set of DTI data using gradient directions; rotating the gradient directions by an angle ?; repeating the step of scanning the test object to acquire a second set of DTI data; creating a composite data set from the first and second sets of data; and applying an inverse Fourier transform to the composite data set.Type: ApplicationFiled: May 5, 2009Publication date: October 29, 2009Applicant: MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE, INCInventor: Nathan E. Yanasak
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Patent number: 7598287Abstract: The present invention provides improved treatment methods by the administration of both an inhibitor of indoleamine-2,3-dioxygenase in addition to the administration of an additional therapeutic agent.Type: GrantFiled: February 17, 2004Date of Patent: October 6, 2009Assignee: Medical College of Georgia Research Institute, Inc.Inventors: David Munn, Andrew Mellor