Abstract: A protein-lipid vesicle that can be used to make an autogenous vaccine comprises patient-specific antigen, adjuvant or immunomodulator, and lipid carrier. In addition, a negatively charged lipid component is desirably included. The autogenous vaccine is useful to treat individuals with chronic diseases, including chronic infectious diseases and neoplasias. The chronic infectious diseases that can be treated include disease caused by infection with human immunodeficiency viruses.
Type:
Grant
Filed:
November 9, 1998
Date of Patent:
December 26, 2000
Assignees:
Albany Medical College, Medical College of New Jersey
Inventors:
James M. Oleske, Thomas N. Denny, Anthony J. Scolpino, Eleonora Feketeova, Susan Gould-Fogerite, Raphael J. Mannino