Patents Assigned to Medical College of Ohio
  • Patent number: 7605130
    Abstract: A composition comprising an albumin-based colloid and its use in treating hypovolemic conditions such as capillary leak syndrome and shock are disclosed.
    Type: Grant
    Filed: November 6, 2007
    Date of Patent: October 20, 2009
    Assignee: Medical College of Ohio
    Inventors: Ragheb Assaly, John D. Dignam, Joseph I. Shapiro
  • Patent number: 7592422
    Abstract: The present invention is based upon the discovery that modified plasminogen activator inhibitor type-I (PAI-1) in which two or more amino acid residues that do not contain a sulfhydryl group have been replaced with amino acid residues that contain a sulfhydryl group and, therefore, forms intramolecular disulfide bonds, have increased in vivo half-life. Also disclosed are the modified PAI-1 proteins, derivatives and analogs thereof, specific antibodies, nucleic acid molecules and host cells. Methods for producing modified PAI-1, derivatives and analogs are also provided. The invention further relates to Therapeutics, pharmaceutical compositions and method of using the composition for treatment. The invention may be used to inhibit angiogenesis in a subject, thereby treating diseases or conditions associated with undesired angiogenesis and cell proliferation. Such conditions include psoriasis, chronic inflammation, tumor invasion and metastasis and conditions in which angiogenesis is pathogenic.
    Type: Grant
    Filed: March 4, 2003
    Date of Patent: September 22, 2009
    Assignee: Medical College of Ohio
    Inventors: Rafal Swiercz, Steven H. Selman, Jerzy Jankun, Joanna Chorostowska-Wynimko, Ewa Skrzypczak-Jankun
  • Patent number: 7348312
    Abstract: A composition comprising an albumin-based colloid and its use in treating hypovolemic conditions such as capillary leak syndrome and shock are disclosed.
    Type: Grant
    Filed: March 22, 2006
    Date of Patent: March 25, 2008
    Assignee: Medical College of Ohio
    Inventors: Ragheb Assaly, John D. Dignam, Joseph I. Shapiro
  • Patent number: 7262027
    Abstract: The present invention provides compositions of novel polypeptides and polynucleotides encoding the polypeptides, which polypeptides are useful for generating an immunological response in an individual and in therapeutic application of Coccidioides spp. infection.
    Type: Grant
    Filed: March 3, 2004
    Date of Patent: August 28, 2007
    Assignees: Medical College of Ohio, The Regents of the University of California, United States of America Represented by the Department of Veterans Affairs
    Inventors: Garry T. Cole, Jieh-Juen Yu, Jianmin Xue, Chiung-Yu Hung, Kalpathi R. Seshan, Theo N. Kirkland, III
  • Publication number: 20060188908
    Abstract: The present invention is directed to methods and compositions for evaluating nucleic acids, methods of preparing such compositions, and applications and business methods employing such compositions and methods. In particular, the present invention provides business methods for operating a gene expression measurement service.
    Type: Application
    Filed: January 23, 2006
    Publication date: August 24, 2006
    Applicants: Medical College of Ohio, Gene Express, Inc.
    Inventors: James Willey, Brad Austermiller, Erin Crawford, Charles Knight, Terry Osborn, Robert Zahorchak
  • Publication number: 20060188909
    Abstract: The present invention is directed to methods and compositions for evaluating nucleic acids, methods of preparing such compositions, and applications and business methods employing such compositions and methods. In particular, the present invention provides business methods for operating a gene expression measurement service.
    Type: Application
    Filed: January 23, 2006
    Publication date: August 24, 2006
    Applicants: Medical College of Ohio, Gene Express, Inc.
    Inventors: James Willey, Brad Austermiller, Erin Crawford, Charles Knight, Terry Osborn, Robert Zahorchak
  • Publication number: 20060190192
    Abstract: The present invention is directed to methods and compositions for evaluating nucleic acids, methods of preparing such compositions, and applications and business methods employing such compositions and methods. In particular, the present invention provides business methods for operating a gene expression measurement service.
    Type: Application
    Filed: January 23, 2006
    Publication date: August 24, 2006
    Applicants: Medical College of Ohio, Gene Express, Inc.
    Inventors: James Willey, Brad Austermiller, Erin Crawford, Charles Knight, Terry Osborn, Robert Zahorchak
  • Publication number: 20060183144
    Abstract: The present invention is directed to methods and compositions for evaluating nucleic acids, methods of preparing such compositions, and applications and business methods employing such compositions and methods. In particular, the present invention provides business methods for operating a gene expression measurement service.
    Type: Application
    Filed: January 23, 2006
    Publication date: August 17, 2006
    Applicants: Medical College of Ohio, Gene Express, Inc.
    Inventors: James Willey, Brad Austermiller, Erin Crawford, Charles Knight, Terry Osborn, Robert Zahorchak
  • Patent number: 7037895
    Abstract: A composition comprising an albumin-based colloid and its use in treating hypovolemic conditions such as capillary leak syndrome and shock are disclosed.
    Type: Grant
    Filed: March 26, 2002
    Date of Patent: May 2, 2006
    Assignee: Medical College of Ohio
    Inventors: Ragheb Assaly, John D. Dignam, Joseph I. Shapiro
  • Publication number: 20050260233
    Abstract: The present invention provides compositions of attenuated fungal mutants and polynucleotide sequences used to transform fungal strains by gene deletions or gene replacements, which are useful for generating an immunological response in human and animals and in therapeutic applications of infections due to pathogenic Coccidioides spp. fungi, such as C. immitis or C. posadasii.
    Type: Application
    Filed: April 7, 2005
    Publication date: November 24, 2005
    Applicant: MEDICAL COLLEGE OF OHIO
    Inventors: Garry Cole, Charles Okeke, Chiung-Yu Hung
  • Publication number: 20040181046
    Abstract: The present invention provides compositions of novel polypeptides and polynucleotides encoding the polypeptides, which polypeptides are useful for generating an immunological response in an individual and in therapeutic application of Coccidioides spp. infection.
    Type: Application
    Filed: March 3, 2004
    Publication date: September 16, 2004
    Applicant: MEDICAL COLLEGE OF OHIO
    Inventors: Garry T. Cole, Jieh-Juen Yu, Jianmin Xue, Chiung-Yu Hung, Kalpathi R. Seshan, Theo N. Kirkland
  • Publication number: 20040038284
    Abstract: This invention is based on the discovery that the type II TGF&bgr; receptor (RII) is a cancer suppressor gene which is genetically inactivated (mutated) in approximately 25% of colon cancers, including nearly all colon cancers of the class identified as mutator/microsatellite instability/RER. Methods are provided for detecting inactivation of RII for use in cancer diagnosis or prognosis.
    Type: Application
    Filed: August 21, 2003
    Publication date: February 26, 2004
    Applicants: Case Western Reserve University, Medical College of Ohio
    Inventors: Sanford D. Markowitz, Michael G. Brattain, James K. V. Willson
  • Patent number: 6630326
    Abstract: This invention is based on the discovery that the type II TGF&bgr; receptor (RII) is a cancer suppressor gene which is genetically inactivated (mutated) in approximately 25% of colon cancers, including nearly all colon cancers of the class identified as mutator/microsatellite instability/RER. Methods are provided for detecting inactivation of RII for use in cancer diagnosis or prognosis.
    Type: Grant
    Filed: June 13, 2001
    Date of Patent: October 7, 2003
    Assignees: Case Western Reserve University, Medical College of Ohio
    Inventors: Sanford D. Markowitz, Michael G. Brattain, James K. V. Willson
  • Publication number: 20020106380
    Abstract: The present invention provides bacterial plasymids and recombinant SOW proteins that are useful as antigens for serodiagnosis of coccidiomycosis.
    Type: Application
    Filed: May 7, 2001
    Publication date: August 8, 2002
    Applicant: Medical College of Ohio
    Inventors: Chiung-Yu Hung, Garry T. Cole
  • Publication number: 20020015693
    Abstract: The present invention relates to a method of modulating an immune response to a T-cell or thymus independent antigen in a host (e.g., mammalian, including human), comprising administering to the host an effective amount of interleukin-12 (IL-12) and the T-cell independent antigen. In one embodiment, the present invention relates to a method of inducing an immune response to a TI antigen in a host (e.g., mammalian, including human), which comprises administering to the host an effective amount of interleukin-12 (IL-12) and the TI antigen. In another embodiment, the present invention relates to a method of enhancing an immune response against a TI antigen in a host, which comprises administering to the host an effective amount of IL-12 and the TI antigen. The methods of the present invention can be used, for example, to induce and or enhance a humoral immune response (IgG2a and/or IgG3 humoral immune response).
    Type: Application
    Filed: August 8, 2001
    Publication date: February 7, 2002
    Applicant: The Medical College of Ohio
    Inventors: Dennis W. Metzger, Renee M. Buchanan
  • Patent number: 6303114
    Abstract: The present invention relates to a method of modulating an immune response to a T-cell or thymus independent antigen in a host (e.g., mammalian, including human), comprising administering to the host an effective amount of interleukin-12 (IL-12) and the T-cell independent antigen. In one embodiment, the present invention relates to a method of inducing an immune response to a TI antigen in a host (e.g., mammalian, including human), which comprises administering to the host an effective amount of interleukin-12 (IL-12) and the TI antigen. In another embodiment, the present invention relates to a method of enhancing an immune response against a TI antigen in a host, which comprises administering to the host an effective amount of IL-12 and the TI antigen. The methods of the present invention can be used, for example, to induce and or enhance a humoral immune response (IgG2a and/or IgG3 humoral immune response).
    Type: Grant
    Filed: March 5, 1998
    Date of Patent: October 16, 2001
    Assignee: The Medical College of Ohio
    Inventors: Dennis W. Metzger, Renee M. Buchanan
  • Patent number: 6291237
    Abstract: This invention is based on the discovery that the type II TGF&bgr; receptor (RII) is a cancer suppressor gene which is genetically inactivated (mutated) in approximately 25% of colon cancers, including nearly all colon cancers of the class identified as mutator/microsatellite instability/RER. Methods are provided for detecting inactivation of RII for use in cancer diagnosis or prognosis.
    Type: Grant
    Filed: January 29, 1999
    Date of Patent: September 18, 2001
    Assignees: Case Western Reserve University, Medical College of Ohio
    Inventors: Sanford D. Markowitz, Michael G. Brattain, James K. V. Willson
  • Patent number: 6075128
    Abstract: The subject invention concerns novel polynucleotide sequences which code for polypeptides which bind IgA. A further aspect of the invention are hybrid proteins (and genes encoding these hybrid proteins) which comprise binding domains for both IgA and IgG.
    Type: Grant
    Filed: February 2, 1998
    Date of Patent: June 13, 2000
    Assignee: Medical College of Ohio
    Inventor: Ervin Faulmann
  • Patent number: 6025351
    Abstract: Families of Diels Alder adducts and of metal complexes of Diels Alder adducts, which are useful as particularly active compounds for use in photodynamic therapy, are disclosed. The Diels Alder adducts and a preferred family of metal complexes have the structures of Formulas 3 and 4, below: ##STR1## where R1, R2, R3 and R4 can be the same or different, and each is methyl, ethyl, an amino acid moiety which is a part of an amide produced by reaction between an amine function of a naturally occurring amino acid and a carbonyl function of the adduct, or a monoclonal antibody moiety which is attached to the adduct moiety through a carbonyl which is a part of an amide produced by reaction between an amine function of a monoclonal antibody and a CO.sub.2 R', CH.sub.2 CO.sub.2 R' or CH.sub.2 CH.sub.2 CO.sub.
    Type: Grant
    Filed: November 26, 1997
    Date of Patent: February 15, 2000
    Assignees: University of Toledo, Medical College of Ohio
    Inventors: Alan R. Morgan, Steven H. Selman
  • Patent number: 5985264
    Abstract: The present invention relates to a method of inducing a Th1-like response against a pathogen in a neonatal host, which comprises administering to the neonatal host an effective amount of IL-12 and an antigen of the pathogen. Also encompassed by the present invention is a method of overcoming suppression of interferon-.gamma. (IFN-.gamma.) expression in a neonatal host due to exposure of the neonatal host to a pathogen or an antigen, which comprises administering to the neonatal host an effective amount of IL-12 and the antigen. The present invention also relates to a method of enhancing the cytokine expression against or in response to a pathogen in a neonatal host, which comprises administering to the neonatal host an effective amount of IL-12 and an antigen of the pathogen.
    Type: Grant
    Filed: March 5, 1998
    Date of Patent: November 16, 1999
    Assignee: The Medical College of Ohio
    Inventors: Dennis W. Metzger, Bernard P. Arulanandam