Patents Assigned to Medical College of Wisconsin, Inc.
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Patent number: 11969265Abstract: Systems and methods for training and implementing a machine learning algorithm to generate feature maps depicting spatial patterns of features associated with osteolysis, synovitis, or both. MRI data, including multispectral imaging data, are input to the trained machine learning algorithm to generate the feature maps, which may indicate features such as a location and probability of a pathology classification, a severity of synovitis, a type of synovitis, a synovial membrane thickness, and other features associated with osteolysis or synovitis. In some implementations, synovial anatomy are segmented in the MRI data before inputting the MRI data to the machine learning algorithm. These segmented MRI data may be generated using another trained machine learning algorithm.Type: GrantFiled: March 4, 2019Date of Patent: April 30, 2024Assignees: The Medical College of Wisconsin, Inc., New York Society for the Relief of the Ruptured and Crippled, Maintaining the Hospital for Special SurgeryInventors: Kevin M. Koch, Andrew S. Nencka, Robin A. Karr, Bradley J. Swearingen, Hollis Potter, Matthew F. Koff
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Patent number: 11959096Abstract: Provided herein are methods of reducing or eliminating undifferentiated pluripotent stem cells, where the methods comprise contacting an effective amount of a compound to a heterogeneous cell population or sample comprising or suspected of comprising differentiated cell types and undifferentiated pluripotent stem cells, whereby the contacting selectively reduces or eliminates undifferentiated pluripotent stem cells from the cell population or sample. Also provided are methods for obtaining a population of stem cell-derived cell types substantially free of undifferentiated pluripotent stem cells as well as isolated populations of such of stem cell-derived cell types.Type: GrantFiled: September 18, 2020Date of Patent: April 16, 2024Assignees: The Medical College of Wisconsin, Inc., The Government of the United States of America as Represented by the Secretary of the Department of Health and Human Services NIH, Office of Technology TransferInventors: Rebekah L. Gundry, Kenneth R. Boheler, Erin M. Kropp
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Patent number: 11911010Abstract: A medical instrument port is described for use with a surgical mask or other protective face covering. The medical instrument port provides a sealed pathway through which a medical instrument can be passed without exposing the clinician to aerosolized droplets expelled from the patient's respiratory system when the medical instrument is introduced into the patient's nasal and/or oral passages.Type: GrantFiled: May 5, 2021Date of Patent: February 27, 2024Assignee: The Medical College of Wisconsin, Inc.Inventors: B. Tucker Woodson, David M. Poetker, Guilherme Garcia, Bonnie Patricia Freudinger, David R. Friedland, Todd A. Loehrl
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Patent number: 11899288Abstract: Certain embodiments of the present invention are directed to therapeutic intervention in patients with eye-length-related disorders to prevent, ameliorate, or reverse the effects of the eye-length-related disorders. Embodiments of the present invention include methods for early recognition of patients with eye-length-related disorders, therapeutic methods for inhibiting further degradation of vision in patients with eye-length-related disorders, reversing, when possible, eye-length-related disorders, and preventing eye-length-related disorders. Additional embodiments of the present invention are directed to particular devices used in therapeutic intervention in patients with eye-length-related disorders.Type: GrantFiled: June 26, 2023Date of Patent: February 13, 2024Assignee: The Medical College of Wisconsin, Inc.Inventors: Jay Neitz, Maureen Neitz
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Patent number: 11897910Abstract: The present invention provides mito-honokiol or mito-magnolol compounds, pharmaceutical compositions thereof, and methods of using the mito-honokiol or mito-magnolol compounds in the treatment of cancer.Type: GrantFiled: November 16, 2020Date of Patent: February 13, 2024Assignees: The Medical College of Wisconsin, Inc., Aix-Marseille UniversiteInventors: Balaraman Kalyanaraman, Jacek Michal Zielonka, Gang Cheng, Micael J. Hardy, Olivier Ouari, Ming You
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Publication number: 20240026437Abstract: This invention relates to methods and compositions for assessing an amount of total cell-free DNA, such as from a transplant subject. The methods and composition provided herein can be used to determine risk of complications following transplantation, including infection, cardiac arrest, and death, in a subject.Type: ApplicationFiled: June 28, 2023Publication date: January 25, 2024Applicant: The Medical College of Wisconsin, Inc.Inventors: Aoy Tomita Mitchell, Michael Mitchell
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Patent number: 11823800Abstract: Systems and methods are described for segmenting medical images, such as magnetic resonance images, using a deep learning model that has been trained using random dropped inputs, standardized inputs, or both. Medical images can be segmented based on anatomy, physiology, pathology, other properties or characteristics represented in the medical images, or combinations thereof. As one example, multi-contrast magnetic resonance images are input to the trained deep learning model in order to generate multiple segmented medical images, each representing a different segmentation class.Type: GrantFiled: October 11, 2019Date of Patent: November 21, 2023Assignee: The Medical College of Wisconsin, Inc.Inventors: Robert Thaddeus Wujek, Kathleen Marie Schmainda
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Patent number: 11819186Abstract: A compression device is used to increase intra-luminal pressure within the upper esophageal sphincter of a patient in order relieve an impact of an abnormal or defective upper esophageal sphincter anatomy, physiology, or functionality. In one implementation, the compression device is used in conjunction with an external pressure sensing device to determine the external pressure that is to be applied to the cricoid for a specific patient. The compression device can be a means for the management and/or treatment of abnormal upper esophageal sphincter functionality, or a means for strengthening an esophageal sphincter of a subject, or a means for curing esophageal reflux disease of a subject, or a means for improving vocal function in a subject, or a means for managing lung aspiration, or a means for applying cricoid pressure during anesthesia intubation, or a means for stabilizing body structures such as during medical imaging or radiation treatment.Type: GrantFiled: July 13, 2020Date of Patent: November 21, 2023Assignees: The Medical College of Wisconsin, Inc., Respiratory Technology CorporationInventors: Nick T. Maris, James S. Miller, Reza Shaker, Timothy Bachman, Nathan Schlueter, Eugene Paul Maloney, Eric David North, Paul Raine, Peter Alex
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Patent number: 11815745Abstract: Certain embodiments of the present invention are directed to therapeutic intervention in patients with eye-length-related disorders to prevent, ameliorate, or reverse the effects of the eye-length-related disorders. Embodiments of the present invention include methods for early recognition of patients with eye-length-related disorders, therapeutic methods for inhibiting further degradation of vision in patients with eye-length-related disorders, reversing, when possible, eye-length-related disorders, and preventing eye-length-related disorders. Additional embodiments of the present invention are directed to particular devices used in therapeutic intervention in patients with eye-length-related disorders.Type: GrantFiled: October 20, 2022Date of Patent: November 14, 2023Assignee: The Medical College of Wisconsin, Inc.Inventors: Jay Neitz, Maureen Neitz
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Patent number: 11771749Abstract: The present disclosure provides compositions and methods of eliciting an anti-tumor immune response and treating cancer comprising at least one peptide of KRAS.Type: GrantFiled: February 5, 2018Date of Patent: October 3, 2023Assignees: The Medical College of Wisconsin, Inc., National Institutes of Health (NIH)Inventors: Jing Pan, Ming You, Ronald Lubet
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Patent number: 11773434Abstract: This invention relates to methods and compositions for assessing an amount of total cell-free DNA, such as from a transplant subject. The methods and composition provided herein can be used to determine risk of complications following transplantation, including infection, cardiac arrest, and death, in a subject.Type: GrantFiled: June 20, 2018Date of Patent: October 3, 2023Assignee: The Medical College of Wisconsin, Inc.Inventors: Aoy Tomita Mitchell, Michael Mitchell
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Patent number: 11725234Abstract: This invention relates to methods and compositions for assessing an amount of total cell-free DNA, such as from a transplant subject. The methods and composition provided herein can be used to determine risk of complications following transplantation, including infection, cardiac arrest, and death, in a subject.Type: GrantFiled: June 20, 2018Date of Patent: August 15, 2023Assignee: The Medical College of Wisconsin, Inc.Inventors: Aoy Tomita Mitchell, Michael Mitchell
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Patent number: 11721021Abstract: A method of detecting the presence of a prostate cancer in a human subject comprising the steps of (a) obtaining a histologically normal prostate tissue sample from the patient and (b) quantifying the epithelial thickness or gland lumen roundness of the tissue, wherein an increase in epithelial thickness or a decrease in gland lumen roundness indicates the presence of prostate cancer or a prostate cancer field defect.Type: GrantFiled: August 25, 2022Date of Patent: August 8, 2023Assignees: Wisconsin Alumni Research Foundation, The Medical College of Wisconsin, Inc.Inventors: David Frazier Jarrard, Bing Yang, Peter LaViolette
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Patent number: 11707283Abstract: An esophageal device is used to recognize, diagnose, characterize, or relieve an impact of an abnormal or defective UES anatomy, physiology, or functionality. In one implementation, the esophageal device measures a UES response to esophageal fluid infusion to detect or characterize an abnormality or defective UES anatomy, physiology, or functionality. An Upper Esophageal Sphincter compression device is used to increase intra-luminal pressure within the Upper Esophageal Sphincter of a patient in order relieve an impact of an abnormal or defective UES anatomy, physiology, or functionality.Type: GrantFiled: April 21, 2020Date of Patent: July 25, 2023Assignee: THE MEDICAL COLLEGE OF WISCONSIN, INC.Inventor: Reza Shaker
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Patent number: 11708412Abstract: The present invention relates to methods of treating hematologic cancers using a combination of inhibitors of PD-1 or PD-L1 and TIM-3, LAG-3 or CTLA4.Type: GrantFiled: December 23, 2019Date of Patent: July 25, 2023Assignees: Novartis AG, The Medical College of Wisconsin, Inc.Inventors: Bryon Duane Johnson, Robert Millman
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Patent number: 11696701Abstract: Systems and methods for estimating quantitative histological features of a subject's tissue based on medical images of the subject are provided. For instance, quantitative histological features of a tissue are estimated by comparing medical images of the subject to a trained model that relates histological features to multiple different medical image contrast types, whether from one medical imaging modality or multiple different medical imaging modalities. In general, the trained model is generated based on medical images of ex vivo samples, in vitro samples, in vivo samples or combinations thereof, and is based on histological features extracted from those samples. A machine learning algorithm, or other suitable learning algorithm, is used to generate the trained model. The trained model is not patient-specific and thus, once generated, can be applied to any number of different individual subjects.Type: GrantFiled: October 25, 2021Date of Patent: July 11, 2023Assignee: The Medical College of Wisconsin, Inc.Inventor: Peter Sherman Laviolette
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Patent number: 11667721Abstract: The present invention provides novel bispecific antibodies that bind to human CD30 and uses thereof. Methods of treating cancer using the bispecific antibodies described herein are also provided.Type: GrantFiled: September 24, 2019Date of Patent: June 6, 2023Assignees: Medical College of Wisconsin, Inc., University of Virginia Patent FoundationInventors: Jeffrey A. Medin, Lawrence G. Lum, Robyn A. A. Oldham, Archana Thakur
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Publication number: 20230138927Abstract: This invention relates to methods and compositions for assessing an amount of total cell-free DNA, such as from a subject having a pro-inflammatory response, such as a pro-inflammatory response associated with an infection, such as a COVID-19 infection. This invention also relates to compositions and methods for treating subjects having or suspected of having a pro-inflammatory response, such as a pro-inflammatory response associated with an infection, such as a COVID-19 infection. In embodiments, there is a risk of an inappropriate or detrimental pro-inflammatory response, such as in a subject with a COVID-19 infection. The methods and composition provided herein can be used to determine severity and risk of complications in a subject. The methods and composition provided herein can also be used to assess the effectiveness of a therapy in a subject, such as a COVID-19 subject.Type: ApplicationFiled: October 6, 2022Publication date: May 4, 2023Applicant: The Medical College of Wisconsin, Inc.Inventors: Michael Mitchell, Aoy Tomita Mitchell
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Patent number: 11612610Abstract: The present invention provides mito-magnolol compounds, pharmaceutical compositions thereof, and methods of using the mito-magnolol compounds in the treatment of cancer, especially anti-cancer therapy or kinase resistant cancers.Type: GrantFiled: August 9, 2021Date of Patent: March 28, 2023Assignees: Medical College of Wisconsin, Inc., Aix-Marseille UniversiteInventors: Balaraman Kalyanaraman, Jacek Michal Zielonka, Gang Cheng, Micael Joël Hardy, Olivier Ouari
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Patent number: 11597917Abstract: The present invention is related to a dual promoter lentiviral vector and methods of use for the treatment of diseases and disorders, specifically lysosomal storage disorders.Type: GrantFiled: June 6, 2018Date of Patent: March 7, 2023Assignees: The Medical College of Wisconsin, Inc., University Health Network, Washington University in St. LouisInventors: Jeffrey A. Medin, John F. Dipersio, Murtaza S. Nagree