Abstract: This invention relates to agents that are inhibitors or activators of variant forms of endogenous proteins and novel methods of identifying such variants. Of particular interest are inhibitors and activators of endogenous protein variants, encoded by genes which have mutated, which variants often arise or are at least first identified as having arisen following exposure to a chemical agent which is known to be an inhibitor or activator of the corresponding unmutated endogenous protein.

Abstract: Compositions for treatment or prevention of viral infections, such as influenza A and B, coronaviruses, including but not limited to COVID-19 and any variant thereof, and rhinoviruses, along with related treatment methods. Certain compositions according to preferred embodiments may comprise chlorpheniramine and albuterol administered by inhalation in nebulized form.

Abstract: Compositions for treatment or prevention of viral infections, such as influenza A and B, coronaviruses, including but not limited to COVID-19 and any variant thereof, and rhinoviruses, along with related treatment methods. Certain compositions according to preferred embodiments may comprise chlorpheniramine and albuterol administered by inhalation in nebulized form.

Abstract: The present disclosure provides apparatuses and methods for measuring sub-epidermal moisture as an indication of tissue viability and providing information regarding the location of a boundary of non-viable tissue.

Abstract: The present disclosure provides apparatuses and methods for measuring sub-epidermal moisture as an indication of tissue viability and providing information regarding the location of a boundary of non-viable tissue.

Abstract: The present disclosure provides apparatuses and methods for measuring capacitance as an indication of susceptibility to the formation of a diabetic foot ulcer.

Abstract: A guide sheath device with an integrated stabilization wire is provided. The guide sheath device includes an elongate member having a proximal and distal end and a lumen there between and a stabilization wire integrated to the elongate member.

Abstract: A nose compression device for treating a nosebleed of a person. The device includes a wire frame having a straight middle section and two end sections angled with respect to the middle section. The device also has a body attached to the wire frame, and two nasal sponges attached to the body for insertion into the person's nasal passages. The end sections are wider than the user's nose, and the device is slid upward on the user's face so that the nasal sponges enter the user's nasal passages. The end sections are then bent inward to a pinch position where they pinch the upper lateral side surfaces of the user's nose. The nasal sponges can be pre-treated with medication to further stop the nosebleed. Ice pack may also be provided that extends over the compression device. The combination of compression, medication, and cooling facilitate treatment of the nosebleed.

Abstract: The present disclosure provides apparatuses and methods for measuring capacitance as an indication of susceptibility to the formation of a diabetic foot ulcer.

Abstract: This invention relates to methods of identifying, synthesizing, optimizing and profiling compounds that are inhibitors or activators of proteins, both naturally occurring endogenous proteins as well as certain variant forms of endogenous proteins, and novel methods of identifying such variants. The method accelerates the identification and development of compounds as potential therapeutically effective drugs by simplifying the pharmaceutical discovery and creation process through improvements in hit identification, lead optimization, biological profiling, and rapid elimination of toxic compounds. Implementation results in overall cost reductions in the drug discovery process resulting from the corresponding increases in efficiency.

Abstract: A bifurcated catheter and methods of use are disclosed herein. The bifurcated catheter can include a fixed flat wire that is configurable as a stabilization wire. The bifurcated catheter can be configured to improve the initial access and directability by application of a pull force to the stabilization wire, in addition to a push force from the proximal end of the bifurcated catheter. The stabilization wire is anchored once the bifurcated catheter is positioned. The anchored, bifurcated catheter provides stability and pushability to assist the procedural catheter in traversing the tortuous peripheral vasculature.

Abstract: A nasal bulb aspirator that can be sized to fit the needs of infants through adults and is designed to ensure that the tip remains hygienically intact by a one-way valve and a counterbalance system that prevents the tip from touching surrounding surfaces, thereby limiting cross contamination from possibly resistant pathogens.

Abstract: A bifurcated catheter and methods of use are disclosed herein. The bifurcated catheter can include a fixed flat wire that is configurable as a stabilization wire. The bifurcated catheter can be configured to improve the initial access and directability by application of a pull force to the stabilization wire, in addition to a push force from the proximal end of the bifurcated catheter. The stabilization wire is anchored once the bifurcated catheter is positioned. The anchored, bifurcated catheter provides stability and pushability to assist the procedural catheter in traversing the tortuous peripheral vasculature.

Abstract: This invention relates to agents that are inhibitors or activators of variant forms of endogenous proteins and novel methods of identifying such variants. Of particular interest are inhibitors and activators of endogenous protein variants, encoded by genes which have mutated, which variants often arise or are at least first identified as having arisen following exposure to a chemical agent which is known to be an inhibitor or activator of the corresponding unmutated endogenous protein.

Abstract: For percutaneous minimally-invasive intervention in vessels originating from other tortuous vessels, such as the tortuous aortic arch, guide wires/catheters are used to enable procedural catheters to access the vessels where an interventional procedure is needed. Two new methods for fixing a stabilization wire/catheter and providing the needed tension and stabilization without a second percutaneous access are disclosed (1) using a micro-anchor and pin and (2) using a modified Fogarty Balloon. These methods are also usable for access to and treatment of peripheral embolisms in tortuous vessels as well as renal and other visceral interventions.

Abstract: A surgical device capable of interconnecting to an external motorized hand pieces, bending a distal end segment, rotating a window element positioned distal to the distal end segment and rotating independently of it, and actuating a cutting element positioned within the outer window element and rotating independently of it.

Abstract: A system for the intravascular placement of a medical device including a guidewire having a first end and a second end, the first end having a microwhisk positional between a feeding state and a deployed state, a guidewire sheath surrounding the guidewire; and an anchoring device for cooperatively fixing the microwhisk relative to a patient. Also, the method of the intravascular placement of the medical device by inserting the medical device through the body with the guidewire and the microwhisk contained within the guidewire sheath, driving the microwhisk out of the guidewire sheath to position the microwhisk to its deployed state, and engaging the anchoring device from the outside of the body through a body surface into the microwhisk, and further into a stabilizing body component.

Abstract: A biocompatible electronic device incorporating a point-of-use-activated microbattery, the biocompatible electronic device comprising: a housing; a sealed control electronics chamber formed within the housing; control electronics contained within the sealed control electronics chamber for controlling the operation of the biocompatible electronic device; a sealed electrode chamber formed within the housing; a plurality of electrodes contained within the sealed electrode chamber and connected to the control electronics; an access port formed within the housing for providing fluid access to the interior of the sealed electrode chamber; and a removable tab for selectively sealing the access port; such that, upon removal of the removable tab, a contacting fluid can contact the electrodes and act as an electrolyte for activating the microbattery, whereby to enable the microbattery to power the control electronics for the biocompatible electronic device.