Patents Assigned to Medical Instill Technologies, Inc.
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Patent number: 8240934Abstract: A dispenser for dispensing a substance, such as a liquid lipstick or other cosmetic, pharmaceutical or cosmeceutical product, has a body with a variable-volume storage chamber for storing the product. A dispensing portion is connected with the body and a one-way valve for dispensing amounts of product therethrough. The dispensing portion defines a compression chamber in fluid communication with the storage chamber for receiving product therefrom, and an outlet aperture coupled in fluid communication with the compression chamber. The one-way valve has a valve seat, and a visco-elastic valve cover seated on the valve seat and defining a normally-closed, axially-extending seam therebetween forming a fluid-tight seal between the valve cover and valve seat. The flexible valve cover is movable relative to the valve seat, and the seam is connectable in fluid communication with the outlet aperture to allow the passage of product through the seam and out of the dispenser.Type: GrantFiled: January 25, 2010Date of Patent: August 14, 2012Assignee: Medical Instill Technologies, Inc.Inventors: Daniel Py, Julian V. Chan, Giovanni Rodriguez
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Patent number: 8220507Abstract: A dispenser is provided for the delivery of controlled, metered amounts of any of numerous different substances to humans or animals, such as medicaments, pharmaceuticals, cosmetics, and food products, or to deliver materials that may react upon exposure to air, such as glue. Means are provided in the dispenser to effect controlled delivery of a pre-determined amount of the substance contained in the dispenser. A one-way valve is provided to hermetically seal the portion of the dispenser containing the substance to be dispensed.Type: GrantFiled: September 2, 2010Date of Patent: July 17, 2012Assignee: Medical Instill Technologies, Inc.Inventors: Daniel Py, Norbert M. Assion, Julian V. Chan
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Patent number: 8181431Abstract: Apparatus for molding and filling a device having a body defining an opening in communication with an interior chamber for receiving a substance therein, and a closure including a penetrable and resealable portion for sealing the opening and substance received in the device. A mold includes within the aseptic chamber plural mold cavities shaped to form the closure and body, and substantially sterile surfaces extending about and contiguous to the peripheries of the mold cavities. An assembly device including end-of-arm tooling having an engaging portion engageable with each of the body and closure is movable relative to the mold to engage and de-mold the substantially sterile closures and bodies from the mold cavities. Flexible barriers are coupled to the mold and the tool to substantially prevent the passage of contaminants from the molding machine and tool therethrough.Type: GrantFiled: January 24, 2011Date of Patent: May 22, 2012Assignee: Medical Instill Technologies, Inc.Inventors: Daniel Py, Benoit Adamo, John Guthy, Nathaniel Houle, M. Jeffrey Willey
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Patent number: 8171652Abstract: Device and method for lyophilizing a substance within the device and storing therein the lyophilized substance. The device defines a chamber for receiving therein the substance to be lyophilized, a penetrable and resealable portion of the device is penetrable or pierceable by a needle for filling the device with the substance, and a resulting hole therein is resealable by transmitting radiation from a radiation source thereon. A filter is connectable in fluid communication between an interior and exterior of the chamber for permitting fluid to flow therethrough in a direction from the interior to the exterior of the chamber, and for substantially preventing contaminants from flowing therethrough in a direction from the exterior to the interior of the chamber.Type: GrantFiled: June 27, 2011Date of Patent: May 8, 2012Assignee: Medical Instill Technologies, Inc.Inventor: Daniel Py
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Patent number: 8132600Abstract: A container and method are provided for storing fat containing liquid products. The container includes a body defining a storage chamber for receiving the product, and a container closure. A first material portion forms at least most of the surface area overlying the storage chamber that can contact any product therein. Neither the body nor the first material portion leach more than a predetermined amount of leachables into the product or undesirably alter a taste profile thereof. A needle penetrable and thermally resealable second material portion either (i) overlies the first material portion and cannot contact any product within the storage chamber, or (ii) forms a substantially lesser surface area overlying the storage chamber that can contact any product therein in comparison to the first material portion. A sealing portion is engageable with the body to form a substantially dry hermetic seal between the container closure and body.Type: GrantFiled: September 30, 2010Date of Patent: March 13, 2012Assignee: Medical Instill Technologies, Inc.Inventors: Daniel Py, Norbert Assion, Nathaniel Houle, Debashis Sahoo, M. Jeffrey Willey, Eric E. Hartman, John Guthy
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Patent number: 8132695Abstract: A dispenser has a body with a variable-volume storage chamber for storing substance, and a dispensing portion defining a dosage chamber in fluid communication with the storage chamber. A first valve includes a valve seat and a flexible valve cover seated thereon defining a normally-closed fluid-tight seam therebetween. The valve cover relative to moves from the valve seat to allow substance through the seam and out of the dispenser. A second valve allows substance from the storage chamber into the dosage chamber and substantially prevents flow from the dosage chamber into the storage chamber. An actuator is manually movable between (i) a first non-actuated position, and (ii) a second actuated position extending into the dosage chamber for compressing a dose of substance therein, dispensing substance through the first valve. The elasticity of the actuator causes it to return to the first non-actuated position upon manually releasing the actuator.Type: GrantFiled: November 9, 2007Date of Patent: March 13, 2012Assignee: Medical Instill Technologies, Inc.Inventors: Daniel Py, Beniot Adamo
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Patent number: 8112972Abstract: A stopper and container body are molded in the same molding machine. An assembly device, such as a pick and place robot, transfers the stopper from one mold cavity into the opening in the container body located within another mold cavity, or vice versa, to assemble the stopper and container body. Then, the assembled container body and stopper are removed from the molding machine and transported to a needle filling and laser resealing station for filling and laser resealing. A laminar flow source directs a substantially laminar flow of air or sterile gas over the mold surfaces, stoppers and container bodies, and assembly device, to prevent contamination during assembly.Type: GrantFiled: March 2, 2010Date of Patent: February 14, 2012Assignee: Medical Instill Technologies, Inc.Inventor: Daniel Py
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Patent number: 8104644Abstract: A flexible pouch and valve assembly is provided for aseptically storing a substance, dispensing multiple portions of the stored substance therefrom, and maintaining substance remaining in the pouch in an aseptic condition sealed with respect to ambient atmosphere. The flexible pouch and valve assembly are receivable within a relatively rigid housing, and are adapted to cooperate with a pump for pumping discrete portions of substance from the pouch and through the one-way valve to dispense the substance therefrom. The assembly comprises a flexible pouch defining therein a variable-volume storage chamber sealed with respect to the ambient atmosphere for aseptically storing therein multiple portions of the substance. A one-way valve of the assembly includes a valve body defining an axially-extending valve seat and at least one flow aperture extending through the valve body and/or the valve seat.Type: GrantFiled: October 8, 2010Date of Patent: January 31, 2012Assignee: Medical Instill Technologies, Inc.Inventors: Daniel Py, Julian V. Chan, Benoit Adamo, Nathaniel Houle
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Patent number: 8096333Abstract: An assembly includes a support and drive assembly, a first structure and a second structure. The first structure is in operable communication with and supported by the support and drive assembly. The first structure includes at least one needle assembly and is adjustable to receive a plurality of needle assemblies. The second structure is supported by the support and drive assembly. The second structure includes at least one seal assembly and is adjustable to receive a plurality of seal assemblies. A method includes determining a number of vials that are to be filled concurrently and adjusting an assembly to include at least one needle assembly and at least one seal assembly. A number of the needle assemblies and the seal assemblies equals the number of vials.Type: GrantFiled: November 30, 2009Date of Patent: January 17, 2012Assignee: Medical Instill Technologies, Inc.Inventors: Daniel Py, Benoit Adamo, John Guthy
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Patent number: 8071009Abstract: An apparatus and method are provided for molding sterile parts. The apparatus has a first mold portion and a second mold portion. At least one of the first and second mold portions defines a mold cavity configured to receive a molten plastic and form therefrom at least one molded part At least one of the first and second mold portions is movable relative to the other between (i) a closed position for sealing the mold cavity or cavities and molding at least one part therein, and (ii) an open position defining a fluid passageway between the first and second mold portions and permitting the passage of a fluid sterilant therein.Type: GrantFiled: October 17, 2006Date of Patent: December 6, 2011Assignee: Medical Instill Technologies, Inc.Inventors: Daniel Py, Benoit Adamo, John Guthy, Nathaniel Houle, Giovanni Rodriguez
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Patent number: 8007193Abstract: A dispenser for dispensing a substance, such as a pharmaceutical, ophthalmic, dermatological, cosmeceutical, cosmetic or other product, has a body with a variable-volume storage chamber for storing the product. A dispensing portion of the dispenser is connected with the body and has a compression chamber in fluid communication with the storage chamber for receiving substance therefrom, and an outlet aperture coupled in fluid communication with the compression chamber. A one-way valve of the dispenser includes an axially-extending valve seat and an axially-extending flexible valve cover seated on the valve seat and defining a normally-closed, axially-extending seam therebetween forming a fluid-tight seal between the valve cover and valve seat. The flexible valve cover is movable relative to the valve seat and the seam is connectable in fluid communication with the outlet aperture to allow the passage of substance through the seam and out of the dispenser.Type: GrantFiled: February 23, 2010Date of Patent: August 30, 2011Assignee: Medical Instill Technologies, Inc.Inventors: Daniel Py, Julian Chan, David Fellows, Eric E. Hartman, Bing He
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Patent number: 7997447Abstract: A device for storing and dispensing a substance includes a storage chamber for the substance. The container includes a passageway in fluid communication with the storage chamber. The container includes a pierceable wall located on an opposite side of the passageway relative to the storage chamber. The device includes a one-way valve assembly including a piercing portion. At least one of the piercing portion and the pierceable wall is movable relative to the other between a first position wherein the pierceable portion is not piercing the pierceable wall, and a second position wherein the pierceable portion is piercing the pierceable wall allowing the flow of substance from the storage chamber. A removable member is disposed intermediate the valve and the container that prevents movement of at least one of the piercing portion and pierceable wall to the second position until the removable member is removed.Type: GrantFiled: August 16, 2010Date of Patent: August 16, 2011Assignee: Medical Instill Technologies, Inc.Inventors: Daniel Py, Miles J. Flamenbaum, Eric E. Hartman, Nathaniel Houle
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Patent number: 7992597Abstract: Disclosed is a container and method for filling same. The container includes a thermally resealable portion that is fusible in response to thermal energy, and a container body having a sealed empty chamber in fluid communication with the resealable portion for receiving therein a substance. The container also includes a base, a mid-portion, and an upper portion axially spaced from the base on an opposite side of the mid-portion relative to the base. Each of the base and upper portion define a laterally-extending dimension greater than a maximum laterally-extending dimension of the mid-portion. The method of filling the container includes penetrating the resealable portion with an injection member and introducing a substance into the chamber, withdrawing the injection member while engaging the base of the body to substantially prevent axial movement of the body, and applying thermal energy to the resealable portion to thermally fuse the penetrated region thereof.Type: GrantFiled: June 1, 2010Date of Patent: August 9, 2011Assignee: Medical Instill Technologies, Inc.Inventors: Daniel Py, Norbert M. Assion
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Patent number: D644322Type: GrantFiled: November 18, 2010Date of Patent: August 30, 2011Assignee: Medical Instill Technologies, Inc.Inventors: Daniel Py, Norbert M. Assion, Stephanie Ferreira
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Patent number: D644334Type: GrantFiled: March 11, 2010Date of Patent: August 30, 2011Assignee: Medical Instill Technologies, Inc.Inventor: Daniel Py
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Patent number: D650067Type: GrantFiled: February 13, 2009Date of Patent: December 6, 2011Assignee: Medical Instill Technologies, Inc.Inventors: Daniel Py, Norbert M. Assion
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Patent number: D650701Type: GrantFiled: August 9, 2010Date of Patent: December 20, 2011Assignee: Medical Instill Technologies, Inc.Inventors: Daniel Py, Nathaniel Houle, Eric E. Hartman, Miles J. Flamenbaum
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Patent number: D652938Type: GrantFiled: March 17, 2011Date of Patent: January 24, 2012Assignee: Medical Instill Technologies, Inc.Inventors: Daniel Py, Julian Chan, Jeffrey Willey
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Patent number: D655621Type: GrantFiled: October 6, 2010Date of Patent: March 13, 2012Assignee: Medical Instill Technologies, Inc.Inventors: Daniel Py, Julian V. Chan, Luz Gladys Valencia
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Patent number: RE43329Abstract: A medicament-dispensing system includes a cartridge for housing and actuating an accordion-like vial-dispenser for dispensing a calibrated amount of medicament by means of a single actuation motion which sequentially loads the vial-dispenser and dispenses the loaded medicament. The vial-dispenser has a front bellows portion, a rear bellows portion, an internal piston mechanism, a medicament storage chamber and a dosage cavity. The cartridge has a trigger mechanism which acts in concert with a notched lever and a wedge-shaped arm internally located in the cartridge to sequentially load the dosage cavity with medicament and discharge it. Depression of the trigger mechanism simultaneously extends, by means of the notched lever, the front bellows portion and compresses the rear bellows portion to load the dosage cavity with medicament.Type: GrantFiled: April 10, 2003Date of Patent: April 24, 2012Assignee: Medical Instill Technologies, Inc.Inventor: Daniel Py