Patents Assigned to Medical Research Fund of Tel Aviv Sourasky Medical Center
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Patent number: 9279127Abstract: The present invention is directed to constructs, compositions and methods for modulating platelet-type 12 lipoxygenase (12-LO) in adipose tissue in vivo. Specifically, the invention provides constructs encoding expression-inhibiting oligonucleic acids, e.g., antisense and RNA interfering (RNAi) molecules, targeted to a platelet-type 12-LO gene or a transcript thereof, which are capable of reducing or silencing platelet-type 12-LO expression specifically in adipocytes and pre-adipocytes. Vectors of these constructs (including, but not limited to, viral vectors), compositions of them and methods of using same for the treatment and amelioration of conditions associated with excess fat cell mass and obesity are also provided.Type: GrantFiled: November 1, 2007Date of Patent: March 8, 2016Assignee: The Medical Research Fund at the Tel-Aviv Sourasky Medical CenterInventors: Gary Weisinger, Rona Limor, Naftali Stern
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Patent number: 9273338Abstract: The present invention relates to animal model systems comprising a chimera between an avian embryo and a mammalian organism. Specifically, chimeric model systems comprising normal, diseased or genetically transformed mammalian cells and tissues transplanted into avian embryos, and uses thereof for in vivo testing of drugs and therapeutic modalities are disclosed.Type: GrantFiled: December 3, 2012Date of Patent: March 1, 2016Assignees: Bar Ilan University, Medical Research Fund of Tel-Aviv Sourasky Medical CenterInventors: Ron Goldstein, Tamar Tennenbaum, Varda Deutsch
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Publication number: 20130171680Abstract: The present invention relates to animal model systems comprising a chimera between an avian embryo and a mammalian organism. Specifically, chimeric model systems comprising normal, diseased or genetically transformed mammalian cells and tissues transplanted into avian embryos, and uses thereof for in vivo testing of drugs and therapeutic modalities are disclosed.Type: ApplicationFiled: December 3, 2012Publication date: July 4, 2013Applicants: MEDICAL RESEARCH FUND OF TEL-AVIV SOURASKY MEDICAL CENTER, BAR ILAN UNIVERSITYInventors: BAR ILAN UNIVERSITY, Medical Research Fund of Tel-Aviv Sourasky Medi
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Patent number: 8391959Abstract: Method and composition suitable for administering by direct convective interstitial infusion are disclosed. The method comprises: placing at least one direct convective interstitial infusion catheter in contact with the tissue, and pressuring the composition through the catheter. The composition is in a liquefied form having a viscosity above a predetermined value. The predetermined value is selected so as to improve infusion of the compositions into interstitial volumes of the tissue, while minimizing backflow of the compositions along an outer wall of the catheter or leakage into low resistance paths. It is demonstrated that high viscosity results in higher treatment efficiency.Type: GrantFiled: September 29, 2005Date of Patent: March 5, 2013Assignees: Tel HaShomer Medical Research Infrastructure and Services Ltd., Medical Research Fund of Tel Aviv Sourasky Medical CenterInventors: Yael Mardor, Zvi Ram
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Patent number: 8324447Abstract: The present invention relates to animal model systems comprising a chimera between an avian embryo and a mammalian organism. Specifically, chimeric model systems comprising normal, diseased or genetically transformed mammalian cells and tissues transplanted into avian embryos, and uses thereof for in vivo testing of drugs and therapeutic modalities are disclosed.Type: GrantFiled: June 28, 2005Date of Patent: December 4, 2012Assignees: Bar Ilan University, Medical Research Fund of Tel-Aviv Sourasky Medical CenterInventors: Ron Goldstein, Tamar Tennenbaum, Varda Deutsch
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AGENTS CAPABLE OF DOWNREGULATING AN MSF-A - DEPENDENT HIF-1ALPHA AND USE THEREOF IN CANCER TREATMENT
Publication number: 20120128659Abstract: Methods and pharmaceutical compositions for the treatment of cancer or acute ischemia are provided. Also provided are methods of identifying agents capable of preventing the formation of or dissociating the MSF-A-HIF-1alpha protein complex, and methods of determining the prognosis of an individual having cancer by identifying the presence or absence of such a protein complex.Type: ApplicationFiled: February 6, 2012Publication date: May 24, 2012Applicant: Medical Research Fund of Tel Aviv Sourasky Medical CenterInventor: Nicola J. MABJEESH -
Patent number: 8143228Abstract: Methods and pharmaceutical compositions for the treatment of cancer or acute ischemia are provided. Also provided are methods of identifying agents capable of preventing the formation of or dissociating the MSF-A-HIF-1alpha protein complex, and methods of determining the prognosis of an individual having cancer by identifying the presence or absence of such a protein complex.Type: GrantFiled: July 12, 2005Date of Patent: March 27, 2012Assignee: Medical Research Fund of Tel Aviv Sourasky Medical CenterInventor: Nicola J. Mabjeesh
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Publication number: 20110098554Abstract: A method for determining a response of a tissue to a destructive treatment is disclosed. The method comprises providing magnetic resonance images of the tissue, and using the magnetic resonance images for determining the response of the tissue to the destructive treatment. Also disclosed is a method for monitoring convection during direct convective interstitial infusion using a pharmaceutical composition which comprises a therapeutic agent and an MRI contrast agent.Type: ApplicationFiled: September 29, 2005Publication date: April 28, 2011Applicants: Tel HaShomer Medical Research Infrastructure and Services Ltd., Medical Research Fund of Tel Aviv Sourasky Medical CenterInventors: Yael Mardor, Zvi Ram
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Publication number: 20110039791Abstract: The present invention describes the use of an AChE-R-derived peptide, also known as ARP, as an inducer of hemopoietic cell differentiation and expansion, specifically for the granulocytic population. In addition, the use of ARP as an inducer of thrombopoietin and pro-inflammatory cytokines is also presented. ARP may further be used in the pre-transplant priming of hematopoietic stem cells. Other uses and methods utilizing ARP are also described herein.Type: ApplicationFiled: September 24, 2010Publication date: February 17, 2011Applicants: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM, Medical Research Fund at the Tel Aviv Sourasky Medical CenterInventors: Hermona Soreq, Dan Grisaru, Varda Deutsch, Chava Perry, Marjorie Pick
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Patent number: 7838493Abstract: The present invention describes the use of an AChE-R-derived peptide, also known as ARP, as an inducer of hemopoietic cell differentiation and expansion, specifically for the granulocytic population. In addition, the use of ARP as an inducer of thrombopoietin and pro-inflammatory cytokines is also presented. ARP may further be used in the pre-transplant priming of hematopoietic stem cells. Other uses and methods utilizing ARP are also described herein.Type: GrantFiled: February 10, 2005Date of Patent: November 23, 2010Assignees: Yissum Research Development Company of the Hebrew University of Jerusalem, Medical Research Fund at the Tel Aviv Sourasky Medical CenterInventors: Hermona Soreq, Dan Grisaru, Varda Deutsch, Chava Perry, Marjorie Pick
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Publication number: 20100292152Abstract: Isolated polynucleotides encoding novel galectin-8 variants polypeptides are provided. Also provided are methods and kits using same for diagnosing prognosing and treating rheumatoid arthritis (RA) and other joint/chronic inflammatory diseases.Type: ApplicationFiled: May 9, 2006Publication date: November 18, 2010Applicants: Yissum Research Development Co. of the Hebrew University of Jersalem, Medical Research Fund of Tel Aviv Sourasky Medical CenterInventors: Itshak Golan, Dan Caspi, Lora Melnik
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Publication number: 20100062450Abstract: Methods and kits for diagnosing cancer or a pre-malignant lesion by determining the presence and/or level of circulating CD24 of a subject are provided. Also provided are methods and kits for determining if a subject is predisposed to gastrointestinal cancer by the determining the presence or absence, in a homozygous or heterozygous form of cancer associated genotype(s) in the CD24 and/or APC nucleic acid sequences. Also provided are methods and kits for monitoring efficacy of cancer therapy by determining the presence and/or level of circulating CD24 of a subject.Type: ApplicationFiled: January 31, 2007Publication date: March 11, 2010Applicant: Medical Research Fund of Tel Aviv Sourasky Medical CenterInventor: Nadir Arber
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Publication number: 20100057096Abstract: Described is a method for deploying a stent-graft in the aorta, the method including positioning a shunt to go along a portion of a brain-supplying artery (BSA) into the aorta; deploying a stent-graft in the aorta along a portion of the shunt; and removing the shunt. Also described is a removable shunt adapted for deployment along a brain-supplying artery into an aorta to supply blood to the artery during deployment of a stent-graft in the aorta, the removable shunt including a stiff segment that is stiff enough to remain at least partially open when between the aorta and the stent-graft and large enough to allow sufficient blood supply to the brain during the deployment of the stent-graft; and a mechanism for facilitating safe removal of the shunt from between the stent-graft and the aorta.Type: ApplicationFiled: November 19, 2007Publication date: March 4, 2010Applicant: Medical Research Fund of Tel Aviv Sourasky Medical CenterInventor: Yehuda G. Wolf
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Publication number: 20090221478Abstract: Isolated polynucleotides encoding novel galectin-8 variants polypeptides are provided. Also provided are methods and kits using same for diagnosing prognosing and treating rheumatoid arthritis (RA) and other joint/chronic inflammatory diseases.Type: ApplicationFiled: May 9, 2006Publication date: September 3, 2009Applicants: Yissum Research Development Co. of the Hebrew University of Jersalem, Medical Research Fund of Tel Aviv Sourasky Medical CenterInventors: Itshak Golan, Dan Caspi, Lora Melnik
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Publication number: 20090098127Abstract: Methods and pharmaceutical compositions for the treatment of cancer or acute ischemia are provided. Also provided are methods of identifying agents capable of preventing the formation of or dissociating the MSF-A-HIF-1alpha protein complex, and methods of determining the prognosis of an individual having cancer by identifying the presence or absence of such a protein complex.Type: ApplicationFiled: July 12, 2005Publication date: April 16, 2009Applicant: Medical Research Fund of Tel Aviv Sourasky Medical CenterInventor: Nicola J. Mabjeesh
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Publication number: 20030198690Abstract: A method of reducing neointiminal proliferation in a blood vessel, in particular as a result of restenosis, comprising administrating zinc to the blood vessel. Also disclosed is a stent comprising zinc for use in the method.Type: ApplicationFiled: April 22, 2002Publication date: October 23, 2003Applicant: Medical Research Fund of Tel Aviv Sourasky Medical CenterInventors: Jacob George, Gad Keren