Abstract: A method is described for detecting, visualizing, or treating cells, particularly cancerous cells, that express a uPA/uPAR complex. The method employs a PAI-2 conjugate molecule that comprises PAI-2 or a functional derivative, homologue, analogue, chemical equivalent or mimetic thereof, which PAI-2 is bound, linked, or otherwise associated with a toxin or label.
Type:
Grant
Filed:
October 14, 2008
Date of Patent:
August 16, 2011
Assignees:
PAI-2 Pty Limited, University of Wollongong, Medical Scitec Australia Pty Ltd.
Inventors:
Marie Ranson, Barry John Allen, Clive Leighton Bunn
Abstract: A method is described for detecting, visualizing, or treating cells, particularly cancerous cells, that express a uPA/uPAR complex. The method employs a PAI-2 conjugate molecule that comprises PAI-2 or a functional derivative, homologue, analogue, chemical equivalent or mimetic thereof, which PAI-2 is bound, linked, or otherwise associated with a toxin or label.
Type:
Grant
Filed:
February 23, 2001
Date of Patent:
June 16, 2009
Assignees:
PAI-2 Pty Limited, University of Wollongong, Medical Scitec Australia Pty Ltd
Inventors:
Marie Ranson, Barry John Allen, Clive Leighton Bunn