Abstract: A method and apparatus to assess sudomotor function to detect early stage peripheral distal neuropathy. The method sends a low voltage direct current of 1 to 5 volts between pairs of electrodes for a time of between 15 and 60 seconds, switches the current at the middle of the time and measures the peak and slope of the decreased conductance. The method can be used to assess skin blood flow and/or sweat gland density depending on the direction of the current.

Abstract: A method and system for detecting insulin resistance, diabetes, cardiovascular disease and/or autonomic neuropathy in a patient is provided. The method includes measuring a photoplethysmogram (PTG) and galvanic skin response from the patient, executing a spectral analysis on the PTG, comparing values derived from the PTG and the galvanic skin response of the patient to stored clinical data, calculating a PTG cardiovascular risk score based on the comparison, comparing further derived values to predefined values that correspond to certain diseases, including insulin resistance, diabetes, cardiovascular disease and autonomic neuropathy, and displaying the PTG cardiovascular risk score and said certain diseases that correspond to said predefined values.

Abstract: A method and system for determining homeostatic risk in a patient, in order to screen metabolic diseases and/or their complications and/or their treatment management, is provided. The method includes receiving, from one or more sensors coupled with the patient, galvanic skin response, bioimpedance, a photoplethysmogram (PTG), and blood pressure from the patient, calculating a first score based on the PTG, calculating a second score based on the galvanic skin response, calculating a third score based on the bioimpedance, calculating a fourth score based on the blood pressure, calculating a homeostatic risk score based on the first, second, third and fourth scores that were calculated, wherein the homeostatic risk score corresponds to the homeostatic risk of the patient, and displaying the homeostatic risk score.

Abstract: A method and apparatus to assess sudomotor function to detect early stage peripheral distal neuropathy. The method sends a low voltage direct current of 1 to 5 volts between pairs of electrodes for a time of between 15 and 60 seconds, switches the current at the middle of the time and measures the peak and slope of the decreased conductance. The method can be used to assess skin blood flow and/or sweat gland density depending on the direction of the current.

Abstract: A method to detect insulin resistance, diabetes and/or cardiovascular or autonomic neuropathy complications, the method comprising performing a spectral analysis using Fast Fourier Transformation (FFT) of the first derivative of total records of an oximeter wave form (plethysmograph), to obtain 3 frequencies; high (PTGHF), low (PTGLF) and very low (PTGVLF) frequencies wherein the sum of the 3 frequencies is the total power of the spectral analysis in ms2 (PTG TP) and wherein the sum of the amplitude of the 3 frequencies is the PTG Index of the Spectral Analysis (PTGi).