Abstract: A device for use in cryopreservation of blood vessels comprising a pair of stylets insertable into the ends of a dissected blood vessel segment. The stylets are mountable on a support track whereby the blood vessel can be distended and supported during cryopreservation procedures. Also disclosed is a freezing and thawing profile capable of maximizing endothelial cell survival. The use of chondroitin sulfate or similar compound is discussed as a novel cryoprotectant.
Type:
Grant
Filed:
January 23, 1990
Date of Patent:
October 27, 1992
Assignees:
CryoLife Inc., Medical Univ. of South Carolina
Inventors:
Robert T. McNally, Cameron McCaa, Kelvin G. M. Brockbank, Albert E. Heacox, Harvey L. Bank
Abstract: A device for use in cryopreservation of blood vessels comprising a pair of stylets insertable into the ends of a dissected blood vessel segment. The stylets are mountable on a support track whereby the blood vessel can be distended and supported during cryopreservation procedures. Also disclosed is a freezing and thawing profile capable of maximizing endothelial cell survival. The use of chondroitin sulfate or similar compound is discussed as a novel cryoprotectant and DMSO is disclosed as a penetrating cyroprotectant.
Type:
Grant
Filed:
January 23, 1990
Date of Patent:
September 22, 1992
Assignee:
CryoLife, Inc. & Medical Univ. of South Carolina
Inventors:
Robert T. McNally, Cameron McCaa, Kelvin G. M. Brockbank, Albert E. Heacox, Harvey L. Bank
Abstract: A device for use in cryopreservation of blood vessels comprising a pair of styles insertable into the ends of a dissected blood vessel segment. The styles are mountable on a support track whereby the blood vessel can be distended and supported during cryopreservation procedures. Also disclosed is a freezing and thawing profile capable of maximizing endothelial cell survival. The use of chondroitin sulfate or similar compound is discussed as a novel cryoprotectant.
Type:
Grant
Filed:
August 21, 1987
Date of Patent:
September 8, 1992
Assignees:
CryoLife Inc., Medical Univ. of South Carolina
Inventors:
Robert T. McNally, Cameron McCaa, Kelvin G. M. Brockbank, Albert E. Heacox, Harvey L. Bank
Abstract: A device for use in cryopreservation of blood vessels comprising a pair of stylets insertable into the ends of a dissected blood vessel segment. The stylets are mountable on a support track whereby the blood vessel can be distended and supported during cryopreservation procedures. Also disclosed is a freezing and thawing profile capable of maximizing endothelial cell survival. The use of chondroitin sulfate or similar compound is discussed as a novel cryoprotectant.
Type:
Grant
Filed:
January 23, 1990
Date of Patent:
June 16, 1992
Assignees:
CryoLife, Inc., Medical Univ. of South Carolina
Inventors:
Robert T. McNally, Cameron McCaa, Kelvin G. M. Brockbank, Albert E. Heacox, Harvey L. Bank