Abstract: Interventional procedures on the carotid arteries are performed through a transcervical access while retrograde blood flow is established from the internal carotid artery to a venous or external location. A system for use in accessing and treating a carotid artery includes an arterial access device, a shunt fluidly connected to the arterial access device, and a flow control assembly coupled to the shunt and adapted to regulate blood flow through the shunt between at least a first blood flow state and at least a second blood flow state. The flow control assembly includes one or more components that interact with the blood flow through the shunt.

Abstract: An insertable port connector for connecting to a fluid port of a device to a sterilization apparatus. The port connector includes a connector body and a porous member. The connector body has an insertion portion, a connection portion, and a porous member brace. The insertion portion is insertable into a lumen of the fluid port and has an inlet. The connection portion connects to the sterilization apparatus. The connection portion has an outlet in fluid communication with the inlet and is configured to be fluidly coupled to the sterilization apparatus. The porous member is supported by the insertion portion. The porous member has a porous structure forming a plurality of minute passageways. The porous member is arranged to be inserted into the lumen with the insertion portion. The porous member is biased outward by the porous member brace so that the porous member engages an interior of the fluid port.

Abstract: Provided herein are anti-Programmed Death-Ligand (PD-L1) antibodies, antigen-binding fragments thereof, multispecific antibodies and encoding polynucleotides. Also provided are PD-L1-targeted phthalocyanine dye conjugates, compositions and articles of manufacture containing the conjugates, and methods for their administration to subjects for photoimmunotherapy. In some embodiments, the anti-PD-L1 antibodies, fragments, and conjugates specifically bind to human PD-L1. Among the anti-PD-L1 antibodies are human antibodies and humanized antibodies. Also provided are methods and uses employing the provided anti-PD-L1 antibodies, antigen-binding fragments, and conjugates such for treatment of human patients.

Abstract: A cassette with free flow prevention for use with an ambulatory pump. The cassette includes a free flow prevention clamp and a housing. The free flow prevention clamp includes a clamping section having a first clamp side and a second clamp side. The housing supports the free flow prevention clamp and defines a channel for receiving a tube. The first and second clamp sides extend parallel to the channel and the clamping section extends across the channel. The free flow prevention clamp is configurable within the housing via an actuator assembly in an open condition that allows fluid flow through the tube when force is applied to the clamping section and in a closed condition that prevents fluid flow through the tube when the force is removed from the clamping section.

Abstract: A method of closing a wound includes providing a first bridging portion comprising a first insert having at least one first eyelet, and a first upper layer of material at least partially disposed over the first insert, and a first lower layer of material disposed below the first insert, the first lower layer of material having an adhesive disposed on a first lower surface, wherein the first insert, the first upper layer and the first lower layer form three zones of different elasticity and stiffness than others of the zones.

Abstract: Systems and methods are provided for treating catheter infections. In some embodiments, a device is provided that includes a main body including a first leg configured to engage a catheter, a second leg configured to engage a drainage tube, and a third leg configured to receive one or more optical fibers, and a port coupled to the third leg. The port is configured to provide access for the one or more optical fibers and provide a seal relative to the one or more optical fibers. The one or more optical fibers are configured to disperse light energy in the catheter such that intensity of the light energy dispersed in the catheter is distributed evenly over a length of the one or more optical fibers in both longitudinal and circumferential directions.

Abstract: The embarrassment of passing gas in public is ubiquitous. Accordingly, certain aspects of the present invention are directed to providing filter underwear (also known as underpants) that is generally constructed with a single ply of underwear side panels that are separated by an activated carbon center panel that is removable from the underwear. Certain embodiments contemplate an odor control underwear being an underwear system that generally includes an underwear comprising a pocket that is fit to accommodate a removable activated carbon adsorbent sleeve. Accordingly, after at least one use (i.e., a time of wearing the underwear system), the adsorbent sleeve can be removed from the accommodating pocket, and therefore the underwear, whereby the adsorbent sleeve can be washed, dried, and reinserted in the accommodating pocket for another underwear use.

Abstract: A method is disclosed that includes cutting an outer conductor of an ablation probe to expose a portion of an inner conductor of the ablation probe, the inner conductor extending within the outer conductor, sliding a dielectric along the portion of the inner conductor, distal to the outer conductor, coupling a fitting to the portion of the inner conductor, distal to the dielectric, and sliding a trocar about the outer conductor, the dielectric, and the fitting.

Abstract: A computer-aided method, using a pre-operative planning software tool and patient-specific images, establishes implant parameters that customize selection of a total knee replacement prosthesis. The computer system determines from coronal, axial and sagittal image slices of a knee joint a neutral boundary axis, a set of epicondylar and trochlear features that define an elliptical cam, and a medial-lateral tibial slope, then defines from overlapping condylar and trochlear circles an ellipse with eccentricity 0.25 and focal points coincident with the circles. A knee prosthesis has a femoral component as an elliptical cam with dimensions defined by the ellipse, and has tibial and patellar components interacting with the femoral component as cam followers under knee flexion. A prosthesis is selected from a set with differing coronal asymmetry angle ? to closely match the patient a as estimated from the images.

Abstract: A percutaneous lead for spinal cord stimulation has a body extending between a distal end and a proximal end. One or more contacts are on the body positioned toward the distal end. At least one anchor is configured to extend from a retracted position to a deployed position to secure the percutaneous lead.

Abstract: Medical devices coupled to a sensor, and systems including such devices, can generate data and analysis based on that data, which may be used to identify and/or address problems associated with the implanted medical device, including incorrect placement of the device, unanticipated degradation of the device, and undesired movement of the device. Also provided are medical devices coupled to a sensor, and devices and methods to address problems that have been identified with an implanted medical device.

Abstract: The invention provides topical compositions and methods for using the compositions. The compositions can be used for the treatment of fibrotic or connective tissue disorders involving scarring, sub-dermal plaque accumulations, or fibrosis of muscle tissue. The disorders can be painlessly treated by the topical application of a composition described herein. One or more calcium channel blocker agents can serve as an active ingredient of the compositions, optionally in combination with, for example, one or more of emu oil and superoxide dismutase. The composition can further include pharmaceutically acceptable carriers that can facilitate the non-invasive transdermal delivery of the active(s) to subdermal sites.

Abstract: A surgical tool that has a pair of transmissions coupled to one another to effect driving of a cutting tool in both bidirectional intermittent rotational manners and in opposite directions of continuous rotation. The transmissions are driven by a motor coupled to one of the transmissions which is coupled to the second transmission.

Abstract: Infusion pumps and associated methods for delivering medicament to a user during error conditions. An infusion pump can include a sensor, a pumping mechanism to deliver medicament through an infusion set to the user, and a processor operably coupled to the sensor and the pumping mechanism. The processor can be configured to receive an indication from the sensor of an error condition, and continue operating the pumping mechanism to deliver a predetermined quantity of medicament without correcting the error condition. The predetermined quantity can be based at least in part on a characteristic of the infusion set.

Abstract: A method of treating a patient having overactive bladder symptoms by a combination of stimulation of the patient's saphenous nerve and the patient's posterior tibial nerve. The method uses a neurostimulator having a computer processor and a signal generator which generates a first stimulation signal which is used to target the patient's saphenous nerve and a second stimulation signal which is used to target the posterior tibial nerve of the patient in accordance with a treatment protocol. The neurostimulator sends the first and second electrical stimulation signals to respective stimulators which then transmit the respective electrical stimulation signals to the patient's saphenous nerve and the patient's posterior tibial nerve in accordance with the stimulation protocol. The first and second stimulators are positioned in locations on the body of the patient to effectively modulate the patient's saphenous nerve and posterior tibial nerve respectively.

Abstract: The present disclosure relates to a device assembly and a method for treating heart failure by normalizing elevated blood pressure in the left atrium of a heart of a mammal Disclosed herein is a RF energy-based transcatheter interatrial septum excision device configured to create a sized interatrial aperture between the right and left atria of a heart for the relief of elevated left atrial pressure. The device assembly comprises a delivery catheter, a tissue stabilizer attached to a tissue stabilizer catheter, a tissue cutter attached to a tissue cutter catheter, a remotely located RF generator connected to an RF cathode and anode of the device assembly.

Abstract: A wound closure device in the form of a force modulating deep skin staple. The deep skin staple includes a bridge portion extending along a longitudinal axis to support a first set of staple legs and an opposing second set of staple legs. Each staple leg coupled to the bridge portion via a spring arm. Each staple leg angled towards a middle section of the bridge portion. The staple legs designed to modulate forces with a wound down into the reticular dermis layer when applied to the wound.

Abstract: A wearable blood analyte measurement device includes a casing defining an appendage-receiving bore and having an interior volume. A plurality of magnets is within interior volume. The magnets produce a magnetic field in the bore. A nuclear magnetic resonance (NMR) transceiver is supported by the casing and positioned to emit radiofrequency (RF) pulses to and receive NMR signals from the bore. An electronics assembly is within the interior volume and in communication with the NMR transceiver. A power source is in the interior volume and powers the NMR transceiver and the electronics assembly.

Abstract: A rod bender includes a first handle arm and a second handle arm coupled to a first pivot point. A body portion of the rod bender is coupled to the first handle arm at a second pivot point and the second handle arm is coupled to the body portion at a third pivot point. The body portion also includes first and second distal arms configured with first and second rolling elements and navigation arrays coupled to distal ends of the first and second distal arms. A barrel is provided on the body portion which is positioned on a center area of the body portion. The navigation arrays have optical markers that are tracked by camera. A three-dimensional reconstruction of a rod bent by the rod bender is created using tracked position of the optical markers during bending.

Abstract: A method for reducing foreign body response in a subject caused by an electrode implanted in a subject's neural tissue at a target site provides positioning a device having a body, ultrasonic transducer, and acoustic coupling medium in contact with the neural tissue proximate to the target site. The method continues with activating a transducer, generating acoustic vibrations, transmitting the acoustic vibrations to the neural tissue at the target site, and applying the acoustic vibrations to the neural tissue at the target site sufficient to reduce the foreign body response in the neural tissue at the target site. The acoustic vibrations are preferably in the ultrasonic range and are pulsed for a duration of 5-200 milliseconds. A treatment protocol may consist of repeat sessions in which the transducer is activated and the acoustic vibrations are applied for 1-15 minutes, then turned off for 1-15 minutes, and repeated 2-10 times.