Patents Assigned to Medidata Solutions, Inc.
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Patent number: 11804287Abstract: A method for calculating a subject's state or condition comprises integrating data that are captured from multiple sources, storing the integrated data in a first database, calculating time intervals in which to collect an optimal amount of data to predict the subject state, developing a predictive model using a recorded diary or electronic data capture information, testing the model against a portion of the captured data, and applying the predictive model to new data from other sources. The predictive model may determine a subject state that may be a digital bio-marker for a disease condition. A system for predicting subject state is also disclosed.Type: GrantFiled: February 24, 2015Date of Patent: October 31, 2023Assignee: MEDIDATA SOLUTIONS, INC.Inventors: David Lee, Kara Dennis, John Savage
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Patent number: 11640446Abstract: A method for generating a synthetic dataset from an original dataset includes encoding categorical features of the original dataset, embedding the encoded dataset in a low-dimensional space, selecting a seed record from the embedded dataset, identifying a plurality of nearest neighbor records to the seed record, generating a new record by randomly selecting features from the plurality of nearest neighbor records, and concatenating the new record into the synthetic dataset. For a synthetic dataset that contains N records, which may be the same as or different from the number of records in the original dataset, the selecting, identifying, generating, and concatenating operations operate a total of N times on the records in the embedded dataset.Type: GrantFiled: August 19, 2021Date of Patent: May 2, 2023Assignee: Medidata Solutions, Inc.Inventors: Mandis Beigi, Jacob Aptekar, Afrah Shafquat, Jason Mezey
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Patent number: 11494680Abstract: A system for predicting subject enrollment for a study includes a time-to-first-enrollment (TTFE) model and a first-enrollment-to-last-enrollment (FELE) model for each site in the study. The TTFE model includes a Gaussian distribution with a generalized linear mixed effects model solved with maximum likelihood point estimation or with Bayesian regression, and the FELE model includes a negative binomial distribution with a generalized linear mixed effects model solved with maximum likelihood point estimation or with Bayesian regression estimation.Type: GrantFiled: May 15, 2018Date of Patent: November 8, 2022Assignee: MEDIDATA SOLUTIONS, INC.Inventors: Hrishikesh Karvir, Fanyi Zhang, Jingshu Liu, Michael Elashoff, Christopher Bound
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Patent number: 11490833Abstract: An apparatus for performing a remote test of range of motion of a person operating a user device includes a transceiver, a processor, and a display. The transceiver is configured to transmit a link to the user device and to receive motion data from the user device. The processor is configured to calculate in real time, based on the motion data, the position of the user device to enable real-time display to a test provider of the performance of the test and to determine in real time the quality of the test. The display is configured to show in real time a continuous indication of the performance of the test and quality results of the test. A method for performing a remote test of range of motion of a person operating a user device is also described and claimed.Type: GrantFiled: July 3, 2017Date of Patent: November 8, 2022Assignee: MEDIDATA SOLUTIONS, INC.Inventors: Jingshu Liu, Pramod Somashekar, Philip Beineke, Andrew Howland, Francois Meunier, John Savage
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Patent number: 11154235Abstract: A perspiration sensing system includes a sensor patch and a smart device. The sensor patch includes one or more perspiration sensing portions. The one or more perspiration sensing portions include an inlet having a predefined size to receive perspiration from a predefined number of sweat glands and an outlet for reducing back pressure. At least one perspiration sensing portion includes a channel having a colorimetric sensing material that changes color when exposed to perspiration. At least one perspiration sensing portion includes a colorimetric assay in a substrate that changes color when exposed to biochemical components of perspiration. The system further includes a smart device having a camera that can take a picture of the sensor patch and determine the volume, rate of perspiration, and/or biochemical components of the perspiration from the one or more perspiration sensing portions.Type: GrantFiled: April 19, 2017Date of Patent: October 26, 2021Assignee: MEDIDATA SOLUTIONS, INC.Inventors: Roozbeh Ghaffari, Gilbert Lee Huppert, Brian Murphy, Isaiah Kacyvenski
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Patent number: 11029226Abstract: Apparatus, systems, and methods for monitoring head acceleration and/or forces acting thereon are disclosed. A device for monitoring an acceleration or a force acting on the head of a user includes a flexible article adapted to be worn on the head of the user; and a monitoring assembly coupled to the flexible article. The monitoring assembly includes a sensor for measuring a force on the head and transmitting data relating to the force, the sensor disposed proximate to the head, a processor adapted to receive the force data from the sensor, and a flexible strip operatively connecting the sensor and the processor.Type: GrantFiled: July 12, 2018Date of Patent: June 8, 2021Assignees: Reebok International Limited, Medidata Solutions, Inc.Inventors: Paul M. Davis, William Marvin, Steven Fastert, Kevin Dowling, Paul E. Litchfield, Benjamin Schlatka, Gilman Callsen, Robert Rich, Dustin G. Simone, Keith A. Stern, Dennis Gaboriault
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Patent number: 11030345Abstract: Methods and systems of storing and managing regulated content items on a non-regulated storage platform are provided. A representation of a regulated content item representing content of the regulated content item is created. The content of the regulated content item is subject to one or more regulations and the regulated content item is stored on the non-regulated storage platform. The representation of the regulated content item is provided to the non-regulated storage platform for storage. The representation of the regulated content item is configured to be accessible on the non-regulated storage platform. A request to access the regulated content item using the representation of the regulated content item is received. The regulated content item is retrieved from the non-regulated storage platform in response to the received request.Type: GrantFiled: September 26, 2019Date of Patent: June 8, 2021Assignee: Medidata Solutions, Inc.Inventors: Kevin Anthony Barrett, Patrick Michael Pollard, Patrick Roberts, Martin Frid-Nielsen
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Patent number: 11023679Abstract: An apparatus for automatically mapping a verbatim narrative to a term in a medical terminology dictionary includes a natural language processor and a comparator. The natural language processor processes terms from the medical terminology dictionary and from a medical coding decision database to generate a processed database that also includes the original terms from the medical terminology dictionary and the medical coding decision database. The natural language processor also processes the verbatim narrative. The comparator compares the processed verbatim narrative to the terms in the processed database and determines whether the processed verbatim narrative is an exact match to a term in the processed database. The verbatim narrative is mapped to the term in the medical terminology dictionary that corresponds to the term in the processed database that is an exact match. The verbatim narratives may include adverse event narratives, concomitant medication narratives, or other types of narratives.Type: GrantFiled: February 27, 2017Date of Patent: June 1, 2021Assignee: Medidata Solutions, Inc.Inventors: Patricia Allen, Andrew Howland, Philip Beineke, Mark Chandler, Michael Elashoff, Mladen Laudanovic, Jingshu Liu, Michael Cestone, Jenny Liu
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Patent number: 10986465Abstract: An electronic device worn on a user includes one or more accelerometers. The one or more accelerometers generate acceleration information based on acceleration experienced by the electronic device. The electronic device further includes a processor and one or more associated memories, and the one or more associate memories include computer program code executable by the processor. The processor, configured by the computer program code, causes the electronic device to process the acceleration information to extract features from the acceleration information. The processor, configured by the computer program code, further causes the electronic device to process the features to determine the location of the electronic device on the user.Type: GrantFiled: October 22, 2019Date of Patent: April 20, 2021Assignee: MEDIDATA SOLUTIONS, INC.Inventors: Shyamal Patel, Ryan S. McGinnis, Aadithya Prakash, Roozbeh Ghaffari, Milan Raj, Ikaro Silva, Elise Jortberg
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Patent number: 10892041Abstract: A method for determining net complexity of a clinical trial includes determining procedures to be performed during the clinical trial, determining which of the procedures may be routinely performed on clinical trial subjects suffering from the disease that the drug under test is designed to treat, determining the net procedures to be performed for the clinical trial itself, and calculating a complexity score for the net procedures. An apparatus for determining net complexity of a clinical trial is also described and claimed.Type: GrantFiled: December 20, 2013Date of Patent: January 12, 2021Assignee: Medidata Solutions, Inc.Inventors: Lori Shields, Joshua Hartman
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Patent number: 10846424Abstract: A computer-based method for creating enforced, context-specific sharing of ontologically mapped, aggregated medical data includes storing at least one data field in a database as an entity type ontology, receiving context-specific rule configurations corresponding to the entity type ontology, and identifying any conflict between the received context-specific rule and any applicable rule. The context-specific rule configurations include at least one context, one data source, and one entity type ontology data field. If a conflict is identified, the method receives resolution of the conflict and stores the context-specific rule configurations in the database.Type: GrantFiled: September 5, 2014Date of Patent: November 24, 2020Assignee: Medidata Solutions, Inc.Inventors: Justin Thomson, Evan Shore
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Patent number: 10558349Abstract: An improvement to a graphical user interface disposed within a display includes a functional scrollbar, a magnifier disposed on the functional scrollbar to enhance the view of the functional scrollbar, and a filter for selecting attributes of data within a data file. The functional scrollbar includes two parts, one that has a plurality of portions indicative of content of the data file shown on the display and one that has a plurality of portions indicative of content of the data file not shown on the display. The two parts of the scrollbar include portions indicative of content within the data file that matches the filter selection. A system for generating a functional scrollbar is also described and claimed.Type: GrantFiled: September 15, 2015Date of Patent: February 11, 2020Assignee: Medidata Solutions, Inc.Inventors: Matthew Noble, Jay Chen, Kelly Kaplan
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Patent number: 10515060Abstract: A method and system for generating a master clinical database from disparate sources, including public databases, private databases, and data from users, correlating the received data, determining a degree of confidence in and requesting and seeking confirmation of any data matched from the correlated data. The invention may identify key time points and users from whom to seek and receive confirmation of correlated data. The invention may be utilized to create a cross-trial, cross-sponsor, clinical master database that maintains appropriate user, subject and data confidentiality and privacy and which may be utilized to facilitate study design collaboration.Type: GrantFiled: October 29, 2013Date of Patent: December 24, 2019Assignee: Medidata Solutions, Inc.Inventors: Glen de Vries, Michelle Marlborough, Christopher Bound, Joshua Hartman, Jeevan Pendli
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Patent number: 10467220Abstract: A system for generating an effective test data set for testing big data applications includes a data collector, a data analyzer, an input domain modeler, a self-adaptive input domain modeler, and a test data set generator. The data collector collects a high volume of data from an original data set and initial constraints, the data analyzer analyzes the data and the initial constraints to generate analytical results, the input domain modeler automatically generates an input domain model based on the analytical results, the self-adaptive input domain modeler generates a self-adaptive input domain model by combining the input domain model and analytical results, and the test data set generator generates an initial test data set based on the self-adaptive input domain model. A method for generating an effective test data set for testing big data applications is also described.Type: GrantFiled: January 29, 2016Date of Patent: November 5, 2019Assignee: Medidata Solutions, Inc.Inventors: Nan Li, Anthony Escalona
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Patent number: 10362086Abstract: A method for automating the submission of issue reports includes automatically capturing information and images related to a software user, receiving a request from the user involving an issue experienced by the user, evaluating the request and the user information and images, generating a unique identifier that matches a response received by the user when making the request to associated server log information, generating an issue report based on the user information and images, server log information, and the generated unique identifier, and generating a ticket associated with the issue report that may be communicated to an external system. The user request information and images, server log information, and unique identifier may be stored in a database or data repository. The user information and images and server log information may be automatically encrypted. A system for automating the submission of issue reports is also described.Type: GrantFiled: December 12, 2014Date of Patent: July 23, 2019Assignee: Medidata Solutions, Inc.Inventor: Charles Abbott
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Patent number: 10320878Abstract: A system for preserving causality of audits may include an upstream service, a downstream service, and an audit service. The upstream service receives a first request including a trace ID and a first span ID, generates a first audit concerning a resource owned by the upstream service and having the trace ID and the first span ID as metadata, persists the first audit to a first database, and generates a second request including the trace ID, a parent span ID, and a second span ID. The downstream service receives the second request from the upstream service, generates a second audit concerning a resource owned by the downstream service and having the trace ID, second span ID, and parent span ID as metadata, and persists the second audit to a second database. The audit service receives and asynchronously centralizes the first and second audits. The metadata can be used to infer causality of the audits. A method for preserving causality of audits is also disclosed and claimed.Type: GrantFiled: June 4, 2015Date of Patent: June 11, 2019Assignee: Medidata Solutions, Inc.Inventors: Aaron Weiner, Matthew Szenher, Nolan Carroll, Isaac Wong
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Patent number: 10311968Abstract: An apparatus for executing a task includes an authenticator to identify a user, a controller that can receive data from the user, and an authorizer to ensure that the user has access to applications used to execute the task. The controller is able to register or de-register the applications and then determine which if the registered applications should be used to execute the task. The controller then converts the data from the user so that it can be used by the application to execute the task. If the user selects a second task to be executed, the controller can determine which of the registered applications is to be used to execute the second task. Methods for executing multiple tasks are also described.Type: GrantFiled: November 6, 2013Date of Patent: June 4, 2019Assignee: Medidata Solutions, Inc.Inventors: Isaac Wong, Glen de Vries, Matthew Szenher, Jay B Smith, Andrew Smith, Joseph Rugilio, Bernardo Pontes, Andrew Newbigging, Chad Albers
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Patent number: 10235633Abstract: A method for linking records (related to an entity) from separate databases may include extracting a first record from a first database as a first vector, extracting a second record from a second database as a second vector, generating first and second sub-vectors for the first and second vectors, where each sub-vector includes quality features from the respective vector, pre-processing the first and second sub-vectors using domain knowledge, calculating a distance assessment classifier based on the first and second sub-vectors, and determining whether the distance represented by the distance assessment classifier is greater than a threshold. If the distance is greater than the threshold, the records may be linked; if not, the method extracts additional records and repeats after generating first and second sub-vectors until the distance is greater than the threshold. A system for linking records is also disclosed.Type: GrantFiled: December 19, 2014Date of Patent: March 19, 2019Assignee: Medidata Solutions, Inc.Inventors: Vladimir Tereshkov, Syed Haider, Valerio Aimale, Joshua Hartman, Christopher Bound, Ron Katriel
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Patent number: 10025828Abstract: A method for generating a unified database includes receiving a structured set of data, where each set is made up of records having fields, aggregating values within a first field of the records, automatically applying a set of rules to the first field values to determine correlations among the first field values, calculating a confidence level regarding a label for the first field, providing the label to the first field, storing the first field values in the first field in the unified database, and receiving more information to increase the confidence level. A system for generating a clinical database and a method for using the database are also described.Type: GrantFiled: November 17, 2014Date of Patent: July 17, 2018Assignee: Medidata Solutions, Inc.Inventors: Glen de Vries, Michelle Marlborough
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Patent number: D822688Type: GrantFiled: May 11, 2017Date of Patent: July 10, 2018Assignee: Medidata Solutions, Inc.Inventors: David Lee, Joshua Hartman, John Savage, Richard Kwock, Michael Elashoff, Pramod Somashekar