Abstract: An anatomic handle for surgical precision scalpel includes a first upper curved body anatomically corresponding to the curved direction of the forefinger, a second underlying body prolonging the first one, having an asymmetrical overturned-saddle shape, a central are area determined by the combination of the first upper body and the second underlying body, two equal and opposite heads to the two terminal parts of the first curved body constituting on the upper part an ergonomic handle, said the heads presenting each on the lateral side the joint for an interchangeable blade. The peculiarity of the handle is that its morphological characteristics allow several different grips according to the peculiar surgical situation in which the scalpel is used.