Abstract: The present invention relates to a transduction system, comprising (a) a rep-negative AAV vector containing a foreign DNA and (b) a product providing an AAV Rep protein. The invention also relates to the use of the transduction system.
Type:
Grant
Filed:
January 30, 2001
Date of Patent:
August 27, 2002
Assignee:
Medigene, AG
Inventors:
Gerd Maass, Christoph Bogedain, Michael Hallek, Clemens Wendtner, Doris Michl
Abstract: The invention concern a system comprising an AAV vector, which contains a foreign DNA, and rep 68/78 sequences of AAV with delayed expression, these sequences being present (a) in cis or (b) in trans.
Type:
Application
Filed:
July 18, 2001
Publication date:
June 27, 2002
Applicant:
MEDIGENE AG.
Inventors:
Christoph Bogedain, Gerd Maass, Michael Hallek
Abstract: Vaccine formulations comprising viral capsomeres are disclosed along with methods for their production. Therapeutic and prophylactic methods of use for the vaccine formulations are also disclosed.
Abstract: Vaccine formulations comprising viral capsomeres are disclosed along with methods for their production. Therapeutic and prophylactic methods of use for the vaccine formulations are also disclosed.
Abstract: The invention concerns a system comprising an AAV vector, which contains a foreign DNA, and rep 68/78 sequences of AAV with delayed expression, these sequences being present (a) in cis or (b) in trans.
The invention also concerns the use of such a system for the production of AAV vectors.
Type:
Grant
Filed:
August 6, 1999
Date of Patent:
September 25, 2001
Assignee:
Medigene AG
Inventors:
Christoph Bogedain, Gerd Maass, Michael Hallek
Abstract: The present invention relates to a transduction system, comprising (a) a rep-negative AAV vector containing a foreign DNA and (b) a product providing an AAV Rep protein. The invention also relates to the use of the transduction system.
Type:
Grant
Filed:
May 5, 1999
Date of Patent:
March 27, 2001
Assignee:
Medigene AG
Inventors:
Gerd Maass, Christoph Bogedain, Michael Hallek, Clemens Wendtner, Doris Michl
Abstract: The present invention provides an AAV vector having a foreign DNA coding for a protein that boosts immunogenicity of cells. The invention also provides a vaccine containing such a vector and the use of both.
Type:
Grant
Filed:
May 5, 1999
Date of Patent:
January 9, 2001
Assignee:
Medigene AG
Inventors:
Gerhard Maass, Michael Hallek, Christoph Bogedain