Abstract: An electronic capsule (100) is provided. The capsule (100) has a discrete drive element (300) comprising: a housing (109), electronics for making the electronic capsule (100) operable, a pumping mechanism (115) for dosing and displacing a substance, a power source (105) for powering the electronic capsule (100) and enabling the electronics and the pumping mechanism (115) to operate, and a locking mechanism (130); and a discrete payload element (200) comprising: a housing (109), a reservoir (210) for storing the substance, one or more openings (250) in the housing (109) for releasing the substance from the reservoir (210) and a locking mechanism (230) for engaging the drive element locking mechanism (130). Engagement of the drive element locking mechanism (130) with the payload element locking mechanism (230) secures the drive element (300) to the payload element (200), thereby making the electronic capsule (100) operable and specific.

Abstract: Gastrointestinal screening includes disposing a self-contained electronic capsule in a gastrointestinal tract. The electronic capsule is adapted to acquire data that is responsive to one or more physical conditions in the gastrointestinal tract and to compare the acquired data with stored threshold data to generate a discrete output relating to the condition of the gastrointestinal tract.

Abstract: The invention relates to a device for drug administration and/or monitoring the status of a patient, the device comprising a first and a second measuring means, and the time for using the second measuring means being set in accordance with the data of the first measuring means.

Abstract: A sensor comprising a plurality of electrodes having a miniature size and a lower power consumption and a coating exterior to the electrodes, wherein the coating interacts with a target condition thereby producing a change in an electrical property of the electrodes, wherein the change is transduced into an electrical signal by the electrodes. Further a system for medication delivery comprising such sensor and a pill.

Abstract: A device for placement in an environment, particularly a humid environment, for delivery of medication to said environment. The device comprises a reservoir (103) having an orifice (104), a conveying unit for conveying a reservoir's content (106) through the orifice (104) and an actuator arrangement for driving the conveying unit. In order to provide a reliable delivery of medication in a humid environment, the conveying unit comprises an auger (110) extending in the reservoir (103).

Abstract: A kit includes a swallowable capsule (1, 45) with a potentiometric sensor (3), such as a pH sensor, with an unfilled electrolyte cell (31). The kit further includes a separate container (46) containing a liquid electrolyte. The kit can, e.g., be packed in a blister package. After unpacking the capsule the electrolyte cell (31) is filled with the electrolyte.

Abstract: A system and method for delivering a substance to a selected site in an alimentary canal of a human or animal includes an ingestible capsule. The capsule has a compartment for storing the substance; a receiver suitable for receiving a signal through animal tissue; a processor for storing a programmed set of instructions; and an electronic power source. The system and method further has at least one transmitter, disposed on a medically relevant site on a body of the human or animal, for sending the signal to the receiver. The receiver includes a proximity based detector for measuring proximity of the receiver to the at least one transmitter, and the processor instructs a releasing device of the capsule to release the substance upon recognition of a pre-programmed pattern of signals.

Abstract: An apparatus and method for electrochemical fluid analysis comprises a chamber (1202) having a depth dimension for accommodating a volume of a fluid under test, first and second electrodes (A1) disposed within the chamber and extending along the depth dimension in spaced relation with each other, and a soluble solid, such as an annealed polymer, e.g. EUDRAGIT occupying a lateral gap between the first and second electrodes. The rate of dissolution as monitored by electrochemical impedance spectroscopy (EIS) of the soluble solid within the fluid depends on the chemical concentration of a corresponding analyte present in solution in the fluid. In one embodiment a silicon-based integrated circuit device defining an upper margin includes an array of electrodes disposed along said upper margin to permit direct exposure of the electrode array to the fluid under test. The device is constructed using CMOS technology.

Abstract: A drug delivery device (50) is provided comprising a drug reservoir (10) and a piston (11). The drug reservoir (10) is provided for comprising a drug and comprises a flexible wall (22) and a dispensing hole (15) for dispensing the drug into an environment of the drug de delivery device (50). The piston (11) is provide for pressing against the flexible wall (22) to compress the drug reservoir (10) for pushing an amount of the drug through the dispensing hole (15). An adhesion interface (51) between a surface of the piston (11) and the flexible wall (22) prevents sliding between the surface of the piston (11) and the flexible wall (22).

Abstract: A medicine reservoir (10) is provided for use with a drug delivery device (50). The medicine reservoir (10) is arranged for comprising a drug (13) and comprises a dispensing hole (15) for dispensing the drug (13) into an environment of the drug delivery device (50). The medicine reservoir (10) further comprises a deformable plug (14) which plug (14) is removable by pressure caused by a dispensing action of the drug delivery device (50).

Abstract: The present invention discloses an ingestible capsule containing drug and a method for controlled administration of the drug in a mammal for treatment of a disease of the GI tract. The capsule has electronic control means for dispensing the drug substantially to the diseased tissue sites of the GI tract, according to a pre-determined drug release profile obtained prior to administration from the specific mammal.