Patents Assigned to Mediolanum Farmaceutici
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Publication number: 20180086809Abstract: Chimeric soluble receptor of interleukin 10 and relative use in treating tumors and in treating diseases which are characterized by high production of interleukin 10, such as systemic lupus erythematosus.Type: ApplicationFiled: April 26, 2016Publication date: March 29, 2018Applicant: Mediolanum Farmaceutici S.P.A.Inventors: Gilberto Filaci, Daniela Fenoglio, Francesca Ferrera
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Patent number: 8828403Abstract: The present invention relates to the use of telomerase-derived peptides for the treatment of any cancer patients, particularly for the treatment of patients with renal or prostate cancer.Type: GrantFiled: June 16, 2009Date of Patent: September 9, 2014Assignee: Mediolanum Farmaceutici S.p.A.Inventors: Gilberto Filaci, Francesco Indiveri, Paolo Traverso
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Patent number: 6620422Abstract: Compositions comprising a peptide and polylactic-glycolic acid (PLGA) wherein the distribution of the size of the particles of the peptide in the PLGA results highly heterogeneous, suitable to the preparation of subcutaneous implants having a release time at least equal to 6 months.Type: GrantFiled: June 1, 2001Date of Patent: September 16, 2003Assignee: Mediolanum Farmaceutici S.p.A.Inventors: Alain Maquin, Patrice Mauriac, Pierre Marion
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Patent number: 5869484Abstract: Phenylcarbamate derivatives suitable to the use as anticholinesterase substances having the general formula (I) ##STR1## wherein the meaning of R.sub.1 -R.sub.7 and X substituentes together with n will be defined in the text.Type: GrantFiled: January 17, 1997Date of Patent: February 9, 1999Assignee: Mediolanum Farmaceutici S.P.A.Inventors: Patrizia Terni, Lucia Mairani, Giacomina Mandelli, Pier Giuseppe Pagella, Donata Marchesini, Stefano Maiorana, Mario Brufani
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Patent number: 5705493Abstract: Oligosaccharides derived from natural or supersulphated GAGS or their mixtures, with a heparin content less than 1% by wt. having average molecular weight between 2,500 and 15,000 dalton, at least 50% by wt. of said oligosaccharide having a molecular weight in the +20% range in respect of the average molecular weight, providing an exceptional bioavailability and an antithrombin activity equal or higher than the starting GAGS.Type: GrantFiled: June 6, 1995Date of Patent: January 6, 1998Assignee: Mediolanum Farmaceutici S.p.A.Inventor: Gianni Ferrari
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Patent number: 5463012Abstract: Polycarbonates of formula (I) wherein a is an integer from 2 to 300; R.sup.1 and R.sup.2 are the same or different and are independently a polyester residue of formula (III) wherein x and y are integers from 1 to 50, R.sup.4 and R.sup.5, which are the same or different, are aliphatic straight or branched hydrocarbon chains having from 1 to 4 carbon atoms, R.sup.6 is an aliphatic or alicyclic straight or branched chain having from 2 to 18 carbon atoms, or a polyoxyalkylene residue of formula (II), the two groups --R.sup.4 --COO and --R.sup.5 --COO being randomly distributed in the polyester residue, x and y being in any possible ratio from 0 to 100, are synthesized by reacting dihydroxy compounds with 1,1'-carbonyldiimidazole. They are useful for the preparation of bioerosible matrices for biologically active compounds.Type: GrantFiled: December 13, 1993Date of Patent: October 31, 1995Assignee: Mediolanum Farmaceutici S.p.A.Inventors: Paolo Ferruti, Elisabetta Ranucci, Fabio Bignotti
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Patent number: 5424451Abstract: Aminoalkylcarbamic esters of eseroline suitable for use as cholinesterase activity inhibitors, having general formula (I) ##STR1## where R stands for an amine selected out of the group consisting of ##STR2## and n, R1, R2, R3, and R4 are as defined in the text.Type: GrantFiled: January 4, 1994Date of Patent: June 13, 1995Assignee: Mediolanum Farmaceutici S.p.A.Inventors: Maria A. Alisi, Mario Brufani, Maria C. Cesta, Luigi Eieocamo, Gianluca Gostoli, Sperandina Lappa, Pier Giuseppe Pagella, Enrico Ferrari, Stefano Maiorana, Donata Marchesini
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Patent number: 5352703Abstract: 2-benzoylamino-3,5-dibromo-N-(4-hydroxycyclohexyl)benzylamine of formula (I), and pharmaceutically acceptable acid addition salts have antitussive and mucus regulating activities.Type: GrantFiled: November 23, 1992Date of Patent: October 4, 1994Assignee: Mediolanum Farmaceutici S.p.A.Inventor: Giuseppe Quadro
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Patent number: 5352810Abstract: Phosphatidylinositol analogues, inhibitors of phosphatidylinositol-specific phospholipase C of general formula (I) ##STR1## wherein X and R have the meanings specified in the description, suitable for preparing pharmaceutical compositions for the treatment of tumoral, thrombotic and inflammatory type pathologies.Type: GrantFiled: January 23, 1992Date of Patent: October 4, 1994Assignee: Mediolanum Farmaceutici S.p.A.Inventors: Mario Brufani, Maria Candida Cesta, Enrico Ferrari, Luigi Filocamo, Sperandina Lappa, Stefano Maiorana, Pier Giuseppe Pagella
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Patent number: 5302593Abstract: Aminoalkylcarbamic esters of eseroline suitable for use as cholinesterase activity inhibitors, having general formula (I) ##STR1## where R stands for an amine selected out of the group consisting of ##STR2## and n, R1, R2, R3, and R4 are as defined in the text.Type: GrantFiled: June 23, 1993Date of Patent: April 12, 1994Assignee: Mediolanum Farmaceutici S.p.A.Inventors: Maria A. Alisi, Mario Brufani, Maria C. Cesta, Luigi Filocamo, Gianluca Gostoli, Sperandina Lappa, Pier Giuseppe Pagella, Enrico Ferrari, Stefano Maiorana, Donata Marchesini
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Patent number: 5284832Abstract: Iron complexes with conalbumin and its derivatives, such as acetylconalbumin and succinylconalbumin, with an iron content ranging from 2 to 30% by weight, useful for the treatment of sideropenic and hypochromic anaemia, preparation process and pharmaceutical compositions containing them as active ingredients.Type: GrantFiled: October 14, 1992Date of Patent: February 8, 1994Assignee: Mediolanum Farmaceutici S.p.A.Inventors: Gianni Ferrari, Pier G. Pagella, Oscar Baiardo
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Patent number: 5221741Abstract: Process for the preparation of 9-fluoro-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de] [1,4]benzothiazine-6-carboxylic acid hydrochloride (Rufloxacin) by reaction of 2,3,5-trifluoro-4-(4-methyl-1-piperazinyl)benzoyl ethyl acetate with N,N-dimethylformamide dimethylacetal, followed by reaction with 2-aminoethanethiol, intramolecular cyclization by treatment with NaH, hydrolysis with H.sub.2 O and salification with HCl.Type: GrantFiled: May 29, 1992Date of Patent: June 22, 1993Assignee: Mediolanum Farmaceutici S.p.A.Inventors: Violetta Cecchetti, Arnaldo Fravolini, Pier Giuseppe Pagella, Fausto Schiaffella
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Patent number: 5214180Abstract: Phosphatidylinositol of high purity useful for the treatment of central nervous system disorders, prepared from vegetal substances containing it by treating them with reagents suitable for the functionalization of the inositol hydroxy group with protective groups, separating the thus protected phosphatidylinositol by solvent extraction or chromatography, and finally removing said protective groups under conditions which do not modify the phosphatidyl group.Type: GrantFiled: January 16, 1992Date of Patent: May 25, 1993Assignee: Mediolanum Farmaceutici S.p.A.Inventors: Enrico Ferrari, Pier Giuseppe Pagella, Stefano Maiorana, Mario Brufani
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Patent number: 5116963Abstract: A process for preparing dermatan sulphate (DS) of pharmaceutical purity from animal organs rich in micropolysaccharides (MPS), by: a) stabilizing the fresh organs by freezing them either as such or in the form of powder, b) micronizing the material containing the MPS with an aqueous CaCl.sub.2 solution, c) digesting the homogenate comprising the raw material and the CaCl.sub.2 with proteolytic enzyme at alkaline pH and at low temperature, d) acidifying, heating and filtering the lysate, e) treating the filtrate with quaternary ammonium salts able to undergo complexing with and thus precipitate either the DS alone or all the MPS selectively, f) recovering and purifying the DS either directly from the ammonium salt complex containing it or from the complex obtained from the mixture of ammonium salt complexes of all the MPS by fractional solubilization with acetone.Type: GrantFiled: October 23, 1990Date of Patent: May 26, 1992Assignee: Mediolanum Farmaceutici SrlInventors: Rinaldo Del Bono, Luigi De Ambrosi, Gianni Ferrari, Pier L. Rugarli, Pier G. Pagella
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Patent number: 5066802Abstract: A process for preparing pyrido-benzothiazine derivatives having the following general formula: ##STR1## in which R is H or a C.sub.1 -C.sub.6 alkyl or a C.sub.1 -C.sub.6 fluoroalkyl, and R.sub.1 is N-alkyl-3-pyrrolidinalkylamine with C.sub.1 to C.sub.6 alkyls or ##STR2## where R.sub.2 is a C.sub.1 -C.sub.6 alkyl or a C.sub.2 -C.sub.6 alkenyl or an arylalkyl group, possibly substituted by halogen, hydroxy or keto-groups, both in the racemic form and in the optically active form. The process for the preparation of derivatives of formula (I) starts with a first reaction cycle starting from 2,4-difluoro-3-chloronitrobenzene. Said derivatives possess a high antibacterial activity as well as a high bioavailability to tissues. The invention also refers to pharmaceutical compositions containing them as active components.Type: GrantFiled: December 7, 1989Date of Patent: November 19, 1991Assignee: Mediolanum Farmaceutici Srl.Inventors: Patrizia Terni, Stefano Maiorana, Antonio Papagni, Piergiuseppe Pagella
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Patent number: 4987222Abstract: A process for the controlled preparation of low molecular weight glucosaminoglycans by treating conventional high molecular weight glucosaminoglycans in the solid state or in solution form with a rectilinear gamma ray beam at doses within the range of 2.5 to 20 Mrad supplied by successive irradiation stages with cooling intervals between one irradiation stage and the next in the dynamic phase.The mixture obtained is subjected to fractionation, purification, neutralization and lyophilization. The glucosaminoglycans obtained have a molecular weight of between 1000 and 35,000 daltons and are used for the preparation of pharmaceutical compositions possessing antithrombotic, fibinolytic, antiatherogenic and heparin cofactor II activation activity.Type: GrantFiled: November 16, 1987Date of Patent: January 22, 1991Assignees: Mediolanum Farmaceutici Spl, Laboratori Derivati OrganiciInventors: Luigi De Ambrosi, Walter Recchia, Gianni Ferrari
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Patent number: 4978673Abstract: Organic salts of physostigmine derivatives, having the following general mula: ##STR1## in which R is a linear or branched C.sub.2 -C.sub.12 alkyl or a cycloalkyl or an aryl, and X.sub.- is the anion of an organic acid, the process for their preparation and their pharmaceutical use for acetylcholinesterase inhibition purposes.Type: GrantFiled: March 28, 1988Date of Patent: December 18, 1990Assignee: Mediolanum Farmaceutici S.r.l. Consiglio Nazionale Delle RicerchInventors: Carlo Meroni, Stefano Maiorana, Mario Brufani, Massimo Pomponi, Riccardo Bernardi, Pier L. Rugarli, Pier G. Pagella
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Patent number: 4923859Abstract: Pyrido-benzothiazine derivatives having the following general formula: ##STR1## in which R is H or a C.sub.1 -C.sub.6 alkyl or a C.sub.1 -C.sub.6 fluoroalkyl, and R.sub.1 is N-alkyl-3-pyrrolidinalkylamine with C.sub.1 to C.sub.6 alkyls or ##STR2## where R.sub.2 is a S.sub.1 -C.sub.6 alkyl or a C.sub.2 -C.sub.6 alkenyl or an arylalkyl group, possibly substituted by halogen, hydroxy or keto-groups, both in the racemic form and in the optically active form.The invention also comprises the process for the preparation of derivatives of formula (I) starting from 2.4-difluoro-3-chloronitrobenzene.Said derivatives possess a high antibacterial acitvity as well as a high bioavailability to tissues; the invention also refers to pharmaceutical compositions containing them as active components.Type: GrantFiled: September 30, 1988Date of Patent: May 8, 1990Assignee: Mediolanum farmaceutici, S.r.l.Inventors: Patrizia Terni, Stefano Maiorana, Antonio Papagni, Piergiuseppe Pagella
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Patent number: 4910196Abstract: New highly soluble antibacterially active salts of pyridobenzothiazines with organic acids are described.In particular, organic salts of 9-fluoro-10[N-(4'-methyl)piperazinyl]-7-oxo-2,3-dihydro-7H-pyrido[1,2,3][1 ,4]-benzothiazine-6-carboxylic acid are prepared with an acid chosen from the group consisting of methanesulphonic acid, ethanesulphonic acid, n-dodecanesulphonic acid, p-toluenesulphonic acid, 1-actadecanesulphonic acid, 2-chloro-ethanesulphonic acid, 2-bromo-ethanesulphonic acid, 3-hydroxy-propanesulphonic acid, citric acid, malonic acid, gluconic acid, malic acid, lactic acid and L-tartaric acid.A new process is also described for preparing said salts from 2,3,4-trichloronitrobenzene, by way of a 2-fluoro-3-chloro-4-mercapto derivative of the nitrobenzene and cyclizing the corresponding amino derivative.Type: GrantFiled: June 22, 1987Date of Patent: March 20, 1990Assignee: Mediolanum Farmaceutici SrlInventors: Patrizia Terni, Pier L. Rugarli, Stefano Maiorana, Pier G. Pagella, Raffaello Fusco
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Process for preparing high-purity dematan sulphate, and pharmaceutical compositions which contain it
Patent number: 4870166Abstract: A process for preparing dermatan sulphate (DS) of pharmaceutical purity from animal organs rich in mucopolysaccharides (MPS), by: (a) stabilizing the fresh organs by freezing them either as such or in the form of powder, (b) micronizing the material containing the MPS with an aqueous CaCl.sub.2 solution, (c) digesting the homogenate comprising the raw material and the CaCl.sub.2 with proteolytic enzymes at alkaline pH and at low temperature, (d) acidifying, heating and filtering the lysate, (e) treating the filtrate with quaternary ammonium salts able to undergo complexing with and thus precipitate either the DS along or all the MPS selectively, (f) recovering and purifying the DA either directly from the ammonium salt complex containing it or from the complex obtained from the mixture of ammonium salt complexes of all the MPS by fractional solubilization with acetone.Type: GrantFiled: March 19, 1987Date of Patent: September 26, 1989Assignee: Mediolanum Farmaceutici SrlInventors: Rinaldo Del Bono, Luigi De Ambrosi, Gianni Ferrari, Pier L. Rugarli, Pier G. Pagella