Patents Assigned to Mediolanum Farmaceutici
  • Publication number: 20180086809
    Abstract: Chimeric soluble receptor of interleukin 10 and relative use in treating tumors and in treating diseases which are characterized by high production of interleukin 10, such as systemic lupus erythematosus.
    Type: Application
    Filed: April 26, 2016
    Publication date: March 29, 2018
    Applicant: Mediolanum Farmaceutici S.P.A.
    Inventors: Gilberto Filaci, Daniela Fenoglio, Francesca Ferrera
  • Patent number: 8828403
    Abstract: The present invention relates to the use of telomerase-derived peptides for the treatment of any cancer patients, particularly for the treatment of patients with renal or prostate cancer.
    Type: Grant
    Filed: June 16, 2009
    Date of Patent: September 9, 2014
    Assignee: Mediolanum Farmaceutici S.p.A.
    Inventors: Gilberto Filaci, Francesco Indiveri, Paolo Traverso
  • Patent number: 6620422
    Abstract: Compositions comprising a peptide and polylactic-glycolic acid (PLGA) wherein the distribution of the size of the particles of the peptide in the PLGA results highly heterogeneous, suitable to the preparation of subcutaneous implants having a release time at least equal to 6 months.
    Type: Grant
    Filed: June 1, 2001
    Date of Patent: September 16, 2003
    Assignee: Mediolanum Farmaceutici S.p.A.
    Inventors: Alain Maquin, Patrice Mauriac, Pierre Marion
  • Patent number: 5869484
    Abstract: Phenylcarbamate derivatives suitable to the use as anticholinesterase substances having the general formula (I) ##STR1## wherein the meaning of R.sub.1 -R.sub.7 and X substituentes together with n will be defined in the text.
    Type: Grant
    Filed: January 17, 1997
    Date of Patent: February 9, 1999
    Assignee: Mediolanum Farmaceutici S.P.A.
    Inventors: Patrizia Terni, Lucia Mairani, Giacomina Mandelli, Pier Giuseppe Pagella, Donata Marchesini, Stefano Maiorana, Mario Brufani
  • Patent number: 5705493
    Abstract: Oligosaccharides derived from natural or supersulphated GAGS or their mixtures, with a heparin content less than 1% by wt. having average molecular weight between 2,500 and 15,000 dalton, at least 50% by wt. of said oligosaccharide having a molecular weight in the +20% range in respect of the average molecular weight, providing an exceptional bioavailability and an antithrombin activity equal or higher than the starting GAGS.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: January 6, 1998
    Assignee: Mediolanum Farmaceutici S.p.A.
    Inventor: Gianni Ferrari
  • Patent number: 5463012
    Abstract: Polycarbonates of formula (I) wherein a is an integer from 2 to 300; R.sup.1 and R.sup.2 are the same or different and are independently a polyester residue of formula (III) wherein x and y are integers from 1 to 50, R.sup.4 and R.sup.5, which are the same or different, are aliphatic straight or branched hydrocarbon chains having from 1 to 4 carbon atoms, R.sup.6 is an aliphatic or alicyclic straight or branched chain having from 2 to 18 carbon atoms, or a polyoxyalkylene residue of formula (II), the two groups --R.sup.4 --COO and --R.sup.5 --COO being randomly distributed in the polyester residue, x and y being in any possible ratio from 0 to 100, are synthesized by reacting dihydroxy compounds with 1,1'-carbonyldiimidazole. They are useful for the preparation of bioerosible matrices for biologically active compounds.
    Type: Grant
    Filed: December 13, 1993
    Date of Patent: October 31, 1995
    Assignee: Mediolanum Farmaceutici S.p.A.
    Inventors: Paolo Ferruti, Elisabetta Ranucci, Fabio Bignotti
  • Patent number: 5424451
    Abstract: Aminoalkylcarbamic esters of eseroline suitable for use as cholinesterase activity inhibitors, having general formula (I) ##STR1## where R stands for an amine selected out of the group consisting of ##STR2## and n, R1, R2, R3, and R4 are as defined in the text.
    Type: Grant
    Filed: January 4, 1994
    Date of Patent: June 13, 1995
    Assignee: Mediolanum Farmaceutici S.p.A.
    Inventors: Maria A. Alisi, Mario Brufani, Maria C. Cesta, Luigi Eieocamo, Gianluca Gostoli, Sperandina Lappa, Pier Giuseppe Pagella, Enrico Ferrari, Stefano Maiorana, Donata Marchesini
  • Patent number: 5352703
    Abstract: 2-benzoylamino-3,5-dibromo-N-(4-hydroxycyclohexyl)benzylamine of formula (I), and pharmaceutically acceptable acid addition salts have antitussive and mucus regulating activities.
    Type: Grant
    Filed: November 23, 1992
    Date of Patent: October 4, 1994
    Assignee: Mediolanum Farmaceutici S.p.A.
    Inventor: Giuseppe Quadro
  • Patent number: 5352810
    Abstract: Phosphatidylinositol analogues, inhibitors of phosphatidylinositol-specific phospholipase C of general formula (I) ##STR1## wherein X and R have the meanings specified in the description, suitable for preparing pharmaceutical compositions for the treatment of tumoral, thrombotic and inflammatory type pathologies.
    Type: Grant
    Filed: January 23, 1992
    Date of Patent: October 4, 1994
    Assignee: Mediolanum Farmaceutici S.p.A.
    Inventors: Mario Brufani, Maria Candida Cesta, Enrico Ferrari, Luigi Filocamo, Sperandina Lappa, Stefano Maiorana, Pier Giuseppe Pagella
  • Patent number: 5302593
    Abstract: Aminoalkylcarbamic esters of eseroline suitable for use as cholinesterase activity inhibitors, having general formula (I) ##STR1## where R stands for an amine selected out of the group consisting of ##STR2## and n, R1, R2, R3, and R4 are as defined in the text.
    Type: Grant
    Filed: June 23, 1993
    Date of Patent: April 12, 1994
    Assignee: Mediolanum Farmaceutici S.p.A.
    Inventors: Maria A. Alisi, Mario Brufani, Maria C. Cesta, Luigi Filocamo, Gianluca Gostoli, Sperandina Lappa, Pier Giuseppe Pagella, Enrico Ferrari, Stefano Maiorana, Donata Marchesini
  • Patent number: 5284832
    Abstract: Iron complexes with conalbumin and its derivatives, such as acetylconalbumin and succinylconalbumin, with an iron content ranging from 2 to 30% by weight, useful for the treatment of sideropenic and hypochromic anaemia, preparation process and pharmaceutical compositions containing them as active ingredients.
    Type: Grant
    Filed: October 14, 1992
    Date of Patent: February 8, 1994
    Assignee: Mediolanum Farmaceutici S.p.A.
    Inventors: Gianni Ferrari, Pier G. Pagella, Oscar Baiardo
  • Patent number: 5221741
    Abstract: Process for the preparation of 9-fluoro-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de] [1,4]benzothiazine-6-carboxylic acid hydrochloride (Rufloxacin) by reaction of 2,3,5-trifluoro-4-(4-methyl-1-piperazinyl)benzoyl ethyl acetate with N,N-dimethylformamide dimethylacetal, followed by reaction with 2-aminoethanethiol, intramolecular cyclization by treatment with NaH, hydrolysis with H.sub.2 O and salification with HCl.
    Type: Grant
    Filed: May 29, 1992
    Date of Patent: June 22, 1993
    Assignee: Mediolanum Farmaceutici S.p.A.
    Inventors: Violetta Cecchetti, Arnaldo Fravolini, Pier Giuseppe Pagella, Fausto Schiaffella
  • Patent number: 5214180
    Abstract: Phosphatidylinositol of high purity useful for the treatment of central nervous system disorders, prepared from vegetal substances containing it by treating them with reagents suitable for the functionalization of the inositol hydroxy group with protective groups, separating the thus protected phosphatidylinositol by solvent extraction or chromatography, and finally removing said protective groups under conditions which do not modify the phosphatidyl group.
    Type: Grant
    Filed: January 16, 1992
    Date of Patent: May 25, 1993
    Assignee: Mediolanum Farmaceutici S.p.A.
    Inventors: Enrico Ferrari, Pier Giuseppe Pagella, Stefano Maiorana, Mario Brufani
  • Patent number: 5116963
    Abstract: A process for preparing dermatan sulphate (DS) of pharmaceutical purity from animal organs rich in micropolysaccharides (MPS), by: a) stabilizing the fresh organs by freezing them either as such or in the form of powder, b) micronizing the material containing the MPS with an aqueous CaCl.sub.2 solution, c) digesting the homogenate comprising the raw material and the CaCl.sub.2 with proteolytic enzyme at alkaline pH and at low temperature, d) acidifying, heating and filtering the lysate, e) treating the filtrate with quaternary ammonium salts able to undergo complexing with and thus precipitate either the DS alone or all the MPS selectively, f) recovering and purifying the DS either directly from the ammonium salt complex containing it or from the complex obtained from the mixture of ammonium salt complexes of all the MPS by fractional solubilization with acetone.
    Type: Grant
    Filed: October 23, 1990
    Date of Patent: May 26, 1992
    Assignee: Mediolanum Farmaceutici Srl
    Inventors: Rinaldo Del Bono, Luigi De Ambrosi, Gianni Ferrari, Pier L. Rugarli, Pier G. Pagella
  • Patent number: 5066802
    Abstract: A process for preparing pyrido-benzothiazine derivatives having the following general formula: ##STR1## in which R is H or a C.sub.1 -C.sub.6 alkyl or a C.sub.1 -C.sub.6 fluoroalkyl, and R.sub.1 is N-alkyl-3-pyrrolidinalkylamine with C.sub.1 to C.sub.6 alkyls or ##STR2## where R.sub.2 is a C.sub.1 -C.sub.6 alkyl or a C.sub.2 -C.sub.6 alkenyl or an arylalkyl group, possibly substituted by halogen, hydroxy or keto-groups, both in the racemic form and in the optically active form. The process for the preparation of derivatives of formula (I) starts with a first reaction cycle starting from 2,4-difluoro-3-chloronitrobenzene. Said derivatives possess a high antibacterial activity as well as a high bioavailability to tissues. The invention also refers to pharmaceutical compositions containing them as active components.
    Type: Grant
    Filed: December 7, 1989
    Date of Patent: November 19, 1991
    Assignee: Mediolanum Farmaceutici Srl.
    Inventors: Patrizia Terni, Stefano Maiorana, Antonio Papagni, Piergiuseppe Pagella
  • Patent number: 4987222
    Abstract: A process for the controlled preparation of low molecular weight glucosaminoglycans by treating conventional high molecular weight glucosaminoglycans in the solid state or in solution form with a rectilinear gamma ray beam at doses within the range of 2.5 to 20 Mrad supplied by successive irradiation stages with cooling intervals between one irradiation stage and the next in the dynamic phase.The mixture obtained is subjected to fractionation, purification, neutralization and lyophilization. The glucosaminoglycans obtained have a molecular weight of between 1000 and 35,000 daltons and are used for the preparation of pharmaceutical compositions possessing antithrombotic, fibinolytic, antiatherogenic and heparin cofactor II activation activity.
    Type: Grant
    Filed: November 16, 1987
    Date of Patent: January 22, 1991
    Assignees: Mediolanum Farmaceutici Spl, Laboratori Derivati Organici
    Inventors: Luigi De Ambrosi, Walter Recchia, Gianni Ferrari
  • Patent number: 4978673
    Abstract: Organic salts of physostigmine derivatives, having the following general mula: ##STR1## in which R is a linear or branched C.sub.2 -C.sub.12 alkyl or a cycloalkyl or an aryl, and X.sub.- is the anion of an organic acid, the process for their preparation and their pharmaceutical use for acetylcholinesterase inhibition purposes.
    Type: Grant
    Filed: March 28, 1988
    Date of Patent: December 18, 1990
    Assignee: Mediolanum Farmaceutici S.r.l. Consiglio Nazionale Delle Ricerch
    Inventors: Carlo Meroni, Stefano Maiorana, Mario Brufani, Massimo Pomponi, Riccardo Bernardi, Pier L. Rugarli, Pier G. Pagella
  • Patent number: 4923859
    Abstract: Pyrido-benzothiazine derivatives having the following general formula: ##STR1## in which R is H or a C.sub.1 -C.sub.6 alkyl or a C.sub.1 -C.sub.6 fluoroalkyl, and R.sub.1 is N-alkyl-3-pyrrolidinalkylamine with C.sub.1 to C.sub.6 alkyls or ##STR2## where R.sub.2 is a S.sub.1 -C.sub.6 alkyl or a C.sub.2 -C.sub.6 alkenyl or an arylalkyl group, possibly substituted by halogen, hydroxy or keto-groups, both in the racemic form and in the optically active form.The invention also comprises the process for the preparation of derivatives of formula (I) starting from 2.4-difluoro-3-chloronitrobenzene.Said derivatives possess a high antibacterial acitvity as well as a high bioavailability to tissues; the invention also refers to pharmaceutical compositions containing them as active components.
    Type: Grant
    Filed: September 30, 1988
    Date of Patent: May 8, 1990
    Assignee: Mediolanum farmaceutici, S.r.l.
    Inventors: Patrizia Terni, Stefano Maiorana, Antonio Papagni, Piergiuseppe Pagella
  • Patent number: 4910196
    Abstract: New highly soluble antibacterially active salts of pyridobenzothiazines with organic acids are described.In particular, organic salts of 9-fluoro-10[N-(4'-methyl)piperazinyl]-7-oxo-2,3-dihydro-7H-pyrido[1,2,3][1 ,4]-benzothiazine-6-carboxylic acid are prepared with an acid chosen from the group consisting of methanesulphonic acid, ethanesulphonic acid, n-dodecanesulphonic acid, p-toluenesulphonic acid, 1-actadecanesulphonic acid, 2-chloro-ethanesulphonic acid, 2-bromo-ethanesulphonic acid, 3-hydroxy-propanesulphonic acid, citric acid, malonic acid, gluconic acid, malic acid, lactic acid and L-tartaric acid.A new process is also described for preparing said salts from 2,3,4-trichloronitrobenzene, by way of a 2-fluoro-3-chloro-4-mercapto derivative of the nitrobenzene and cyclizing the corresponding amino derivative.
    Type: Grant
    Filed: June 22, 1987
    Date of Patent: March 20, 1990
    Assignee: Mediolanum Farmaceutici Srl
    Inventors: Patrizia Terni, Pier L. Rugarli, Stefano Maiorana, Pier G. Pagella, Raffaello Fusco
  • Patent number: 4870166
    Abstract: A process for preparing dermatan sulphate (DS) of pharmaceutical purity from animal organs rich in mucopolysaccharides (MPS), by: (a) stabilizing the fresh organs by freezing them either as such or in the form of powder, (b) micronizing the material containing the MPS with an aqueous CaCl.sub.2 solution, (c) digesting the homogenate comprising the raw material and the CaCl.sub.2 with proteolytic enzymes at alkaline pH and at low temperature, (d) acidifying, heating and filtering the lysate, (e) treating the filtrate with quaternary ammonium salts able to undergo complexing with and thus precipitate either the DS along or all the MPS selectively, (f) recovering and purifying the DA either directly from the ammonium salt complex containing it or from the complex obtained from the mixture of ammonium salt complexes of all the MPS by fractional solubilization with acetone.
    Type: Grant
    Filed: March 19, 1987
    Date of Patent: September 26, 1989
    Assignee: Mediolanum Farmaceutici Srl
    Inventors: Rinaldo Del Bono, Luigi De Ambrosi, Gianni Ferrari, Pier L. Rugarli, Pier G. Pagella