Abstract: The present invention relates to a method of exposing particles to cytoplasm comprising introducing particles into a live cell; allowing the live cell to contact a cytoplasm exposure additive which can expose the particles from endocytic vesicles to cytoplasm in the cell with maintaining its physiological, biochemical, or biological environment as undamaged; and allowing the particles to be exposed from the endocytic vesicles to the cytoplasm. The present invention is advantageous in that particles delivered into cells can be effectively exposed to cytoplasm from endocytic vesicles in intact cells which maintain their physiological, biochemical, or biological environment as undamaged.

Abstract: The present invention provides a method for imaging a pattern of magnetic materials in a live cell comprising: preparing a plurality of magnetic materials magnetized in a direction of a line of magnetic force by applying a magnetic field, at least one of the magnetic materials being configured into a nanoparticle and the surface of at least one of the magnetic materials being modified; introducing a plurality of the magnetic materials into each live cell; providing the live cell with a label capable of binding to the magnetic material and imaging a pattern of the magnetic materials in a direction of a line of magnetic force; allowing a bundle of the lines of magnetic force to pass through the live cell in a direction by applying a focused magnetic field to the live cell; aligning a plurality of the magnetic materials in the live cell with the direction of the line of magnetic force by the applied magnetic field; and identifying an imaged pattern of the label capable of imaging the aligned pattern of the magne

Abstract: A method for detecting a modulator that can regulate biological and/or physiological activity of a cellular component is provided. The method can detect a modulator, after determining whether there is a competitive reaction between a reference substance and a modulator toward the cellular component in a cell by imaging a magnetic pattern magnetized in a direction of a magnetic line of force and a pattern of a label bound to the cellular component. The method has a benefit that since the reaction of a cellular component with a reference substance and a modulator such as a drug occurs in a cell, the competition reaction between the reference substance and the modulator toward the cellular component can reflect the real metabolism occurred in a live cell. It can also allow the result of interaction between the cellular component and the modulator such as a drug to be visualized and to be identified directly in a live cell.