Abstract: Compounds and methods of using these compounds to treat neurodegenerative diseases, especially Alzheimer's disease, are provided. The compounds that are provided for the treatment of neurodegenerative diseases can be represented by a general formula (I): wherein R1 is Me, Et or PhCH2; R2 is H, PhCH2 or 6-Me-3-Py-(CH2)2; and R3 is H, Me or Br. The solid line accompanied by the dotted line i.e. represents a single or double bond and salts thereof with pharmacologically acceptable acids and quaternary derivatives.
Type:
Grant
Filed:
December 2, 2004
Date of Patent:
July 4, 2006
Assignee:
Medivation, Inc.
Inventors:
Nikolai S. Zefirov, Andrei Z. Afanasiev, Svetlana V. Afanasieva, Sergei O. Bachurin, Sergei E. Tkachenko, Vladmir V. Grigoriev, Marina A. Jurovskaya, Valery P. Chetverikov, Elizaveta E. Bukatina, Irina V. Grigorieva
Abstract: Compounds and methods of using these compounds to treat neurodegenerative diseases, especially Alzheimer's disease, are provided. The compounds that are provided for the treatment of neurodegenerative diseases can be represented by a general formula (I): wherein R1 is Me, Et or PhCH2; R2 is H, PhCH2 or 6-Me-3-Py-(CH2)2; and R3 is H, Me or Br. The solid line accompanied by the dotted line i.e. represents a single or double bond and salts thereof with pharmacologically acceptable acids and quaternary derivatives.
Type:
Application
Filed:
December 2, 2004
Publication date:
May 5, 2005
Applicant:
Medivation, Inc.
Inventors:
Nikolai Zefirov, Andrei Afanasiev, Svetlana Afanasieva, Sergei Bachurin, Sergei Tkachenko, Vladimir Grigoriev, Marina Jurovskaya, Valery Chetverikov, Elizaveta Bukatina, Irina Grigorieva