Patents Assigned to Mediwound Ltd.
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Publication number: 20230414728Abstract: The present invention provides methods for treating skin cancers utilizing pharmaceutical formulations in the form of a hydrogel that includes a proteolytic enzyme mixture obtained from bromelain and a water-soluble gelling agent. In particular, the method is useful for treating non-melanoma skin cancers, pre-cancerous skin lesions, and benign skin lesions.Type: ApplicationFiled: October 18, 2021Publication date: December 28, 2023Applicant: MEDIWOUND LTD.Inventors: Lior ROSENBERG, Dafna GEBLINGER, Eilon ASCULAI
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Patent number: 11382958Abstract: The present invention relates to debriding compositions in the form of an aqueous gel. Particularly, the present invention relates to a debriding composition comprising a proteolytic enzyme mixture obtained from bromelain present in a dry form, and an aqueous gel carrier, wherein, prior to use, the proteolytic enzyme mixture being admixed with the aqueous gel carrier to form a debriding composition useful for debridement and treatment of c wounds.Type: GrantFiled: January 30, 2017Date of Patent: July 12, 2022Assignee: MediWound Ltd.Inventors: Eilon Asculai, Dafna Geblinger, Mery Kleyman, Deborah Hanah Bartfeld
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Patent number: 10293033Abstract: The present invention relates to a proteolytic extract obtained from bromelain for the treatment of connective tissue diseases. In particular, the present invention relates to a pharmaceutical composition comprising a proteolytic extract obtained from bromelain for the treatment of diseases such as Dupuytren's disease and Peyronie's disease.Type: GrantFiled: November 7, 2016Date of Patent: May 21, 2019Assignee: MediWound Ltd.Inventors: Lior Rosenberg, Guy Rubin, Eilon Asculai
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Patent number: 9511126Abstract: The present invention relates to a proteolytic extract obtained from bromelain for the treatment of connective tissue diseases. In particular, the present invention relates to a pharmaceutical composition that includes proteolytic extract obtained from bromelain for the treatment of diseases such as Dupuytren's disease and Peyronie's disease.Type: GrantFiled: July 19, 2012Date of Patent: December 6, 2016Assignee: MediWound Ltd.Inventors: Lior Rosenberg, Guy Rubin, Eilon Asculai
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Patent number: 8540983Abstract: The present invention relates to a debriding composition obtained from bromelain and to methods of producing same. Particularly, the present invention relates to a debriding composition obtained from bromelain comprising proteolytic enzymes having molecular weights of about 23 kDa, being essentially devoid of bromelain inhibitors, and to pharmaceutical compositions comprising same. The debriding compositions and the pharmaceutical compositions comprising same are particularly useful in debriding eschar tissues and in wound healing.Type: GrantFiled: February 6, 2012Date of Patent: September 24, 2013Assignee: MediWound Ltd.Inventors: Marian Gorecki, Amir Toren
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Patent number: 8119124Abstract: The present invention relates to a debriding composition obtained from bromelain and to methods of producing same. Particularly, the present invention relates to a debriding composition obtained from bromelain comprising proteolytic enzymes having molecular weights of about 23 kDa, being essentially devoid of bromelain inhibitors, and to pharmaceutical compositions comprising same. The debriding compositions and the pharmaceutical compositions comprising same are particularly useful in debriding eschar tissues and in wound healing.Type: GrantFiled: November 22, 2005Date of Patent: February 21, 2012Assignee: MediWound Ltd.Inventors: Marian Gorecki, Amir Toren
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Patent number: 7794709Abstract: Apparatus suitable for use in the prevention and treatment of burn induced compartment syndrome facilitates the rapid and efficient deployment of enzymatic compositions to the affected limb or limbs of a burn victim suffering from a circumferential burn. The apparatus includes a flexible, water-impermeable generally cylindrical covering layer. The covering layer has an inner surface facing the limb and an outer surface. The covering layer has a proximal sealable open end through which the burned limb is inserted and a distal closed end. An enzymatic escharotomy agent is contained within the covering layer. The covering layer retains the enzymatic escharotomy agent in close proximity to the burned limb, and the apparatus is enclosed within a sterile sealed package evacuated from moisture.Type: GrantFiled: October 21, 2004Date of Patent: September 14, 2010Assignee: MediWound Ltd.Inventor: Lior Rosenberg
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Publication number: 20090010910Abstract: The invention relates to compositions for debriding damaged skin comprising at least one enzymatic debriding agent and at least one antiseptic compound comprising heavy metal ions. The present invention further relates to kit and methods for topical debridement of damaged skin, particularly of burned skin.Type: ApplicationFiled: July 13, 2005Publication date: January 8, 2009Applicant: MEDIWOUND LTD.Inventors: Amir Toren, Lior Rosenberg, Marian Gorecki
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Patent number: 7128719Abstract: A device, system and method for enhancing the functionality and efficiency of a chemical and/or enzymatic debriding agent with a physical debriding mechanism. The debriding agent alone and the physical mechanism alone are each capable of at least some debriding activity separately, without being used in the combination. In combination, however, they are more effective, such that the debriding efficacy is increased for the combination. Preferably, the physical debriding mechanism comprises an ultrasound source.Type: GrantFiled: July 30, 2001Date of Patent: October 31, 2006Assignee: Mediwound Ltd.Inventor: Lior Rosenberg
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Publication number: 20050202071Abstract: Apparatus suitable for use in the prevention and treatment of burn induced compartment syndrome facilitates the rapid and efficient deployment of enzymatic compositions to the affected limb or limbs of a burn victim suffering from a circumferential burn. The apparatus includes a flexible, water-impermeable generally cylindrical covering layer. The covering layer has an inner surface facing the limb and an outer surface. The covering layer has a proximal sealable open end through which the burned limb is inserted and a distal closed end. An enzymatic escharotomy agent is contained within the covering layer. The covering layer retains the enzymatic escharotomy agent in close proximity to the burned limb, and the apparatus is enclosed within a sterile sealed package evacuated from moisture.Type: ApplicationFiled: October 21, 2004Publication date: September 15, 2005Applicant: MEDIWOUND, LTD.Inventor: Lior Rosenberg