Patents Assigned to MEDIX INC.
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Patent number: 9387029Abstract: Disclosed is a locking spring screw formed from a cylindrical screw body having a screw head that includes a tool slot adapted for receipt of a flexible spring member. The tool slot includes at least one outlet formed adjacent to the tool slot which is adapted for passage therethrough of a tongue extending outwardly from the spring member. A ridge is located opposite the outlet from the cylindrical screw body and formed at least partially around the circumference of the screw head wherein the spring member is retracted during installation and, upon the ridge engaging a flange, the spring member is released preventing screw head removal by entrapping the flange between the ridge and the tongue of the spring member.Type: GrantFiled: December 17, 2010Date of Patent: July 12, 2016Assignee: Asilo Medix, Inc.Inventors: John M. Abrahams, Peter J. Amarosa, Michael Leatherman
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Patent number: 9274109Abstract: The present application relates to a composition including gut flora-derived extracellular vesicles, and to an animal disease model using same. In addition, the present application relates to a method for using the gut flora-derived extracellular vesicles to efficiently search for a candidate drug which may prevent or treat diseases that occur due to gut flora-derived extracellular vesicles, and to a vaccine which can efficiently prevent or treat infections caused by gut flora or diseases that occur due to gut flora-derived extracellular vesicles. Further, the development of diagnostic technology to discover, using the gut flora-derived extracellular vesicles of the present application, the etiology of diseases that occur due to gut flora-derived extracellular vesicles, can be achieved.Type: GrantFiled: July 2, 2014Date of Patent: March 1, 2016Assignee: Aeon Medix Inc.Inventors: Yoon Keun Kim, Yong Song Gho, Kyoung Su Park, Bok Sil Hong, Ji Hyun Kim, You Sun Kim, Won Hee Lee, Jung Wook Kim, Dae-Kyum Kim
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Patent number: 9201072Abstract: The present application relates to a composition including gut flora-derived extracellular vesicles, and to an animal disease model using same. In addition, the present application relates to a method for using the gut flora-derived extracellular vesicles to efficiently search for a candidate drug which may prevent or treat diseases that occur due to gut flora-derived extracellular vesicles, and to a vaccine which can efficiently prevent or treat infections caused by gut flora or diseases that occur due to gut flora-derived extracellular vesicles. Further, the development of diagnostic technology to discover, using the gut flora-derived extracellular vesicles of the present application, the etiology of diseases that occur due to gut flora-derived extracellular vesicles, can be achieved.Type: GrantFiled: July 20, 2010Date of Patent: December 1, 2015Assignee: AEON MEDIX INC.Inventors: Yoon Keun Kim, Yong Song Gho, Kyoung Su Park, Bok Sil Hong, Ji Hyun Kim, You Sun Kim, Won Hee Lee, Jung Wook Kim, Dae-Kyum Kim
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Patent number: 9149542Abstract: The present application relates to microvesicles derived from a protoplast which is a bacterial, arhaea, fungal or plant cell or the like from which a cell wall is removed. The microvesicles derived from a protoplast enables free loading of a material necessary for diagnosis, treatment, vaccine, target induction, cell membrane fusion with a target cell, reduction of in vivo and in vitro side effects, stability improvement, and the like, and allows the therapeutic material, the diagnostic material and/or the vaccine material to be delivered specifically to a specific tissue or cell.Type: GrantFiled: June 30, 2011Date of Patent: October 6, 2015Assignee: AEON MEDIX INC.Inventors: Yong Song Gho, Su Chul Jang, Yoon Keun Kim, Oh Youn Kim
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Patent number: 9084830Abstract: The present application relates to microvesicles derived from a protoplast which is a bacterial, arhaea, fungal or plant cell or the like from which a cell wall is removed. The microvesicles derived from a protoplast enables free loading of a material necessary for diagnosis, treatment, vaccine, target induction, cell membrane fusion with a target cell, reduction of in vivo and in vitro side effects, stability improvement, and the like, and allows the therapeutic material, the diagnostic material and/or the vaccine material to be delivered specifically to a specific tissue or cell.Type: GrantFiled: March 2, 2015Date of Patent: July 21, 2015Assignee: AEON MEDIX INC.Inventors: Yong Song Gho, Su Chul Jang, Yoon Keun Kim, Oh Youn Kim
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Patent number: 9034051Abstract: A bone repair material being superior in apatite-forming ability and its stability in a storage and high in scratch resistance is disclosed. The material is produced by a method comprising the steps of: immersing a substrate made of titanium or a titanium alloy in a first aqueous solution that does not contain calcium ions but contains at least one cation selected from the group consisting of sodium ions and potassium ions and is alkaline; immersing the substrate in a second aqueous solution that does not contain phosphate ions but contains calcium ions; heating the substrate in a dry atmosphere; and treating the substrate with hot water of 60° C. or higher or with steam.Type: GrantFiled: May 23, 2013Date of Patent: May 19, 2015Assignee: ADVANCED MEDIX INC.Inventors: Tadashi Kokubo, Takashi Kizuki, Seiji Yamaguchi, Tomiharu Matsushita
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Patent number: 8969653Abstract: The present application relates to extracellular vesicles (EVs) derived from gram-positive bacteria. In detail, the present application provides animal models of disease using extracellular vesicles derived from gram-positive bacteria, provides a method for screening an active candidate substance which is capable of preventing or treating diseases through the animal models of disease, provides vaccines for preventing or treating diseases caused by extracellular vesicles derived from gram-positive bacteria, and provides a method for diagnosing the causative factors of diseases caused by gram-positive bacteria using extracellular vesicles.Type: GrantFiled: August 26, 2010Date of Patent: March 3, 2015Assignee: Aeon Medix Inc.Inventors: Yong Song Gho, Yoon Keun Kim, Eun Young Lee, Sung Wook Hong, Ji Hyun Kim, Seng Jin Choi
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Patent number: 8784864Abstract: Bone repair materials are disclosed, from which ions are hardly eluted in living body and which are superior in apatite-forming ability and resistance to apatite peeling and have a scratch resistance high enough for practical use. The material comprises a substrate made of titanium or titanium alloys, and a surface layer, made substantially of titanium oxide, along the surface of the substrate. The substrate has on the surface thereof irregularities of from 1 nm to 10 ?m in average in both width and depth. The layer has a zeta potential of +4.5 mV or more under an aqueous solution environment of pH 6 to 8, and a critical scratch resistance of 35 mN or more when vibration 100 ?m in amplitude is added to a stylus with a spring constant of 200 g/mm on the surface layer and the stylus is moved at a rate of 10 mm/sec under a load increasing at a rate of 100 mN/min.Type: GrantFiled: January 29, 2010Date of Patent: July 22, 2014Assignees: Chubu University Educational Foundation, Osaka Yakin Kogyo Co., Ltd, Avanced Medix Inc.Inventors: Tadashi Kokubo, Tomiharu Matsushita, Deepak K. Pattanayak
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Patent number: 8691522Abstract: The present application relates to a composition comprising extracellular membrane vesicles derived from indoor air. In addition, the present application provides a method for diagnosing, preventing and/or treating an inflammatory respiratory disease, lung cancer and the like using the extracellular membrane vesicles. In detail, the present application involves injecting extracellular membrane vesicles present in indoor air into an animal in order to prepare an animal respiratory disease model, and enables the search and/or discovery of drug candidates for preventing or treating respiratory diseases using the animal model.Type: GrantFiled: August 5, 2010Date of Patent: April 8, 2014Assignee: Aeon Medix Inc.Inventors: Yoon Keun Kim, Yong Song Gho, Yu Sun Kim, Eun Jeong Choi, Sung Wook Hong, Eun Young Lee, Bok Sil Hong, Jun Pyo Choi, Young Koo Ji
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Publication number: 20140044647Abstract: The present invention relates to a microvesicle that is derived from nucleated mammalian cells, which are smaller than the nucleated cells. The microvesicles of the present invention can be used in the delivery of a therapeutic or diagnostic substance to specific tissues or cells, and more particularly, relates to microvesicles derived from monocytes, macrophages, dendritic cells, stem cells or the like, which can be used to deliver specific therapeutic or diagnostic substances for treating and/or diagnosing tissue associated with cancer, diseased blood vessels, inflammation, or the like.Type: ApplicationFiled: October 18, 2013Publication date: February 13, 2014Applicant: Aeon Medix Inc.Inventors: Yong Song GHO, Yoon Keun Kim, Su Chul Jang, Oh Youn Kim, Dong-Sic Choi, Yae Jin Yoon
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Publication number: 20130261765Abstract: A bone repair material being superior in apatite-forming ability and its stability in a storage and high in scratch resistance is disclosed. The material is produced by a method comprising the steps of: immersing a substrate made of titanium or a titanium alloy in a first aqueous solution that does not contain calcium ions but contains at least one cation selected from the group consisting of sodium ions and potassium ions and is alkaline; immersing the substrate in a second aqueous solution that does not contain phosphate ions but contains calcium ions; heating the substrate in a dry atmosphere; and treating the substrate with hot water of 60° C. or higher or with steam.Type: ApplicationFiled: May 23, 2013Publication date: October 3, 2013Applicant: ADVANCED MEDIX INC.Inventors: Tadashi Kokubo, Takashi Kizuki, Seiji Yamaguchi, Tomiharu Matsushita
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Patent number: 8470387Abstract: A bone repair material being superior in apatite-forming ability and its stability in a storage and high in scratch resistance is disclosed. The material is produced by a method comprising the steps of: immersing a substrate made of titanium or a titanium alloy in a first aqueous solution that does not contain calcium ions but contains at least one cation selected from the group consisting of sodium ions and potassium ions and is alkaline; immersing the substrate in a second aqueous solution that does not contain phosphate ions but contains calcium ions; heating the substrate in a dry atmosphere; and treating the substrate with hot water of 60° C. or higher or with steam.Type: GrantFiled: June 1, 2009Date of Patent: June 25, 2013Assignee: Advanced Medix Inc.Inventors: Tadashi Kokubo, Takashi Kizuki, Seiji Yamaguchi, Tomiharu Matsushita
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Publication number: 20130115241Abstract: The present application relates to microvesicles derived from a protoplast which is a bacterial, arhaea, fungal or plant cell or the like from which a cell wall is removed. The microvesicles derived from a protoplast enables free loading of a material necessary for diagnosis, treatment, vaccine, target induction, cell membrane fusion with a target cell, reduction of in vivo and in vitro side effects, stability improvement, and the like, and allows the therapeutic material, the diagnostic material and/or the vaccine material to be delivered specifically to a specific tissue or cell.Type: ApplicationFiled: June 30, 2011Publication date: May 9, 2013Applicant: AEON MEDIX INC.Inventors: Yong Song Gho, Su Chul Jang, Yoon Keun Kim, Oh Youn Kim
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Publication number: 20130046323Abstract: Scissors including a first blade member, a second blade member movably connected to the first blade member, and at least one of indicia arranged on at least one of the first and second blade members, indicia formed in at least one of the first and second blade members, and an optional reflex hammer can be arranged on at least one of the first and second blade members.Type: ApplicationFiled: August 15, 2012Publication date: February 21, 2013Applicant: MEDIX INC.Inventor: David WHITAKER
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Publication number: 20120222142Abstract: The present application relates to a composition including gut flora-derived extracellular vesicles, and to an animal disease model using same. In addition, the present application relates to a method for using the gut flora-derived extracellular vesicles to efficiently search for a candidate drug which may prevent or treat diseases that occur due to gut flora-derived extracellular vesicles, and to a vaccine which can efficiently prevent or treat infections caused by gut flora or diseases that occur due to gut flora-derived extracellular vesicles. Further, the development of diagnostic technology to discover, using the gut flora-derived extracellular vesicles of the present application, the etiology of diseases that occur due to gut flora-derived extracellular vesicles, can be achieved.Type: ApplicationFiled: July 20, 2010Publication date: August 30, 2012Applicant: AEON MEDIX INC.Inventors: Yoon Keun Kim, Yong Song Gho, Kyoung Su Park, Bok Sil Hong, Ji Hyun Kim, You Sun Kim, Won Hee Lee, Jung Wook Kim, Dae-Kyum Kim
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Publication number: 20120192295Abstract: The present application relates to a composition comprising extracellular membrane vesicles derived from indoor air. In addition, the present application provides a method for diagnosing, preventing and/or treating an inflammatory respiratory disease, lung cancer and the like using the extracellular membrane vesicles. In detail, the present application involves injecting extracellular membrane vesicles present in indoor air into an animal in order to prepare an animal respiratory disease model, and enables the search and/or discovery of drug candidates for preventing or treating respiratory diseases using the animal model.Type: ApplicationFiled: August 5, 2010Publication date: July 26, 2012Applicant: AEON MEDIX INC.Inventors: Yoon Keun Kim, Yong Song Gho, Yu Sun Kim, Eun Jeong Choi, Sung Wook Hong, Eun Young Lee, Bok Sil Hong, Jun Pyo Choi, Young Koo Ji
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Publication number: 20120177574Abstract: The present invention relates to a microvesicle that is derived from nucleated mammalian cells, which are smaller than the nucleated cells. The microvesicles of the present invention can be used in the delivery of a therapeutic or diagnostic substance to specific tissues or cells, and more particularly, relates to microvesicles derived from monocytes, macrophages, dendritic cells, stem cells or the like, which can be used to deliver specific therapeutic or diagnostic substances for treating and/or diagnosing tissue associated with cancer, diseased blood vessels, inflammation, or the like.Type: ApplicationFiled: July 1, 2010Publication date: July 12, 2012Applicant: AEON MEDIX INC.Inventors: Yong Song Gho, Yoon Keun Kim, Su Chul Jang, Oh Youn Kim, Dong-Sic Choi, Yae Jin Yoon
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Publication number: 20120159658Abstract: The present application relates to extracellular vesicles (EVs) derived from gram-positive bacteria. In detail, the present application provides animal models of disease using extracellular vesicles derived from gram-positive bacteria, provides a method for screening an active candidate substance which is capable of preventing or treating diseases through the animal models of disease, provides vaccines for preventing or treating diseases caused by extracellular vesicles derived from gram-positive bacteria, and provides a method for diagnosing the causative factors of diseases caused by gram-positive bacteria using extracellular vesicles.Type: ApplicationFiled: August 26, 2010Publication date: June 21, 2012Applicant: AEON MEDIX INC.Inventors: Yong Song Gho, Yoon Keun Kim, Eun Young Lee, Sung Wook Hong, Ji Hyun Kim, Seng Jin Choi
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Publication number: 20110287070Abstract: Bone repair materials are disclosed, from which ions are hardly eluted in living body and which are superior in apatite-forming ability and resistance to apatite peeling and have a scratch resistance high enough for practical use. The material comprises a substrate made of titanium or titanium alloys, and a surface layer, made substantially of titanium oxide, along the surface of the substrate. The substrate has on the surface thereof irregularities of from 1 nm to 10 ?m in average in both width and depth. The layer has a zeta potential of +4.5 mV or more under an aqueous solution environment of pH 6 to 8, and a critical scratch resistance of 35 mN or more when vibration 100 ?m in amplitude is added to a stylus with a spring constant of 200 g/mm on the surface layer and the stylus is moved at a rate of 10 mm/sec under a load increasing at a rate of 100 mN/min.Type: ApplicationFiled: January 29, 2010Publication date: November 24, 2011Applicants: Chubu University Educational Foundation, Advanced Medix Inc., Sagawa Printing Co., Ltd.Inventors: Tadashi Kokubo, Tomiharu Matsushita, Deepak K. Pattanayak
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Publication number: 20090317278Abstract: An artificial bone which is easy to bond to a living bone and has a mechanical property approximate to that of a living bone is disclosed. The artificial bone comprises: a dense part made of titanium or a titanium alloy, in the shape of a frame that is approximate to a part of an outer face of a living bone, having a density of 95% or more; and a porous part made of sintered particles of titanium or a titanium alloy having the same or different composition as the titanium alloy for the dense part, in the shape approximate to the remaining part of the living bone, having a porosity of 40% or more, the dense part and the particles of the porous part being sintered to each other at an interface between the dense part and the porous part.Type: ApplicationFiled: August 28, 2007Publication date: December 24, 2009Applicants: JAPAN SCIENCE AND TECHNOLOGY AGENCY, CHUBU UNIVERSITY EDUCATIONAL FOUNDATION, ADVANCED MEDIX INC.Inventor: Tadashi Kokubo