Patents Assigned to Medizinische Hochschule Hannover
  • Patent number: 9915667
    Abstract: Provided herein are methods for diagnosing the presence or the risk of development, or for the therapy control of vasculitis, in particular of large vessel vasculitis, like giant-cell arteritis (GCA), polymyalgia rheumatica (PMR), and Takayasu's arteritis, in a subject analyzing for the presence of antibodies against ferritin, in particular heavy chain ferritin or immunoreactive peptides thereof or ferritin analog protein, preferably bacterial ferritin analog protein, or immunoreactive peptides thereof, in a subject. In addition, test kits for use in the diagnosis of the presence or the risk of development, or for the therapy control of vasculitis, in particular of large vessel vasculitis, like GCA, PMR and Takayasu's arteritis, in a subject are also provided.
    Type: Grant
    Filed: January 27, 2012
    Date of Patent: March 13, 2018
    Assignee: MEDIZINISCHE HOCHSCHULE HANNOVER
    Inventors: Torsten Witte, Niklas Thomas Baerlecken
  • Patent number: 9867956
    Abstract: The invention is related to a medical device (1) for conducting a medical examination and/or intervention within a human or animal body, the medical device (1) comprising a handle (2) and a curved guiding bar (3) connected to the handle (2), the guiding bar (3) comprising a guiding duct (4) adapted for guiding a medical instrument (5) from the handle area to a distal end (7) of the guiding bar (3) which is distant from the handle (2), the guiding bar (3) comprising on its distal end (7) a first camera (6) which is integrated within the guiding bar (3) or attached to the guiding bar (3), whereby the first camera (6) is arranged and adjusted for capturing an area (8) in front of the distal end (7) of the guiding bar (3).
    Type: Grant
    Filed: June 15, 2012
    Date of Patent: January 16, 2018
    Assignee: Medizinische Hochschule Hannover
    Inventor: Konstantinos Raymondos
  • Patent number: 9782350
    Abstract: The present invention relates in a first aspect to a method of coating surfaces of substrates with a lattice-like structure. In particular, the present invention relates to an in vitro method of coating surfaces by binding of epsin or a fragment thereof on the surface and, thereafter, binding of a compound forming the lattice like structure, in particular, binding of the clathrin heavy chain, to the epsin bound on the surface, thus, obtaining a coated substrate having a lattice like structure on the surface. In another aspect, the present invention relates to an in vitro method of producing nanometer-sized liposomes having a clathrin structure on its surface. In addition, substrates, like elements or devices, with coated surfaces having a lattice-like structure on the surface are provided obtainable by a method according to the present invention.
    Type: Grant
    Filed: February 6, 2013
    Date of Patent: October 10, 2017
    Assignee: MEDIZINISCHE HOCHSCHULE HANNOVER
    Inventors: Philip Dannhuser, Ernst Ungewickell
  • Publication number: 20170274021
    Abstract: The method for preparing a tissue construct for medical purposes uses endothelial progenitor cells (EPC) which have not been passaged multiple times and have a content of EOEC (early outgrowth endothelial progenitor cells) and LOEC (late outgrowth endothelial progenitor cells). These cells and fibroblasts and/or muscle cells, viz. myoblasts, myofibroblasts, smooth muscle cells or the progenitors thereof, are, in the form of living cells, seeded onto a matrix or introduced into a matrix in order to yield the tissue construct following further treatment steps. The matrix is preferably a protein preparation, more particularly a fibrinogen preparation. Both the cells and the fibrinogen preparation can be obtained from a single blood sample from a patient. Apart from the preparation of bypass materials, prosthetic vascular graft, tissue patches, conduits and the like, the EOEC-containing EPC culture or suspension is suitable as means for cell transplantation.
    Type: Application
    Filed: April 19, 2017
    Publication date: September 28, 2017
    Applicant: MEDIZINISCHE HOCHSCHULE HANNOVER (MHH)
    Inventors: Axel HAVERICH, Thomas APER, Mathias WILHELMI
  • Patent number: 9765303
    Abstract: The present invention relates to a method for the production of differentiated respiratory epithelial cells comprising: (a) providing a cell population comprising or consisting of precursor cells of respiratory epithelial cells; (b) culturing the cell population of (a) in culture medium to which keratinocyte growth factor has been added; wherein the cultured cell population is supplemented with a glucocorticoid, a cAMP analog and a cAMP elevating agent and wherein said supplementation is either simultaneously with the addition of keratinocyte growth factor in step (b) or prior or subsequently to the addition of keratinocyte growth factor in step (b), thereby differentiating said precursor cells into respiratory epithelial cells.
    Type: Grant
    Filed: February 3, 2012
    Date of Patent: September 19, 2017
    Assignee: MEDIZINISCHE HOCHSCHULE HANNOVER
    Inventors: Ulrich Martin, Christina Mauritz
  • Publication number: 20170203509
    Abstract: The invention relates to a method for manufacturing a component (10) by a generative manufacturing process, wherein the component is entirely or partially produced from a liquid raw material (12), characterised in that the component is entirely or partially produced from a liquid raw material (12) that can solidify when heated, the raw material is discharged in liquid form into a manufacturing zone (1) and heated and hence solidified by a computer-controlled, targeted light spot, in that the point of incidence of a light beam (8) from a light beam source is continuously and/or gradually modified relative to the manufacturing zone (1).
    Type: Application
    Filed: July 17, 2015
    Publication date: July 20, 2017
    Applicant: MEDIZINISCHE HOCHSCHULE HANNOVER
    Inventors: Jan STIEGHORST, Theodor DOLL
  • Patent number: 9662068
    Abstract: The invention is related to a medical device for conducting a medical examination and/or intervention within a human or animal body the medical device (1) comprising an elongate body (2) which is designed for introduction into an orifice (15) of the human or animal body the elongate body (2) comprising a distal end (3), which is on the front side of the elongate body during introduction into the orifice (15), of the human or animal body and a proximal end (4) on the opposite side, wherein the elongate body is a hollow body comprising a reception chamber (8) in its interior, which reception chamber (8) is arranged for reception of a human finger (9), characterized in that one or more guiding elements (5, 21) for guiding a medical examination and/or intervention component (6) are located on or in the elongate body and at least one image gathering device (7), which is arranged for gathering of images in front of the distal end (3) of the elongate body (2), is arranged on or in the elongate body (2).
    Type: Grant
    Filed: January 27, 2012
    Date of Patent: May 30, 2017
    Assignee: Medizinische Hochschule Hannover
    Inventor: Konstantinos Raymondos
  • Patent number: 9655931
    Abstract: The method for preparing a tissue construct for medical purposes uses endothelial progenitor cells (EPC) which have not been passaged multiple times and have a content of EOEC (early outgrowth endothelial progenitor cells) and LOEC (late outgrowth endothelial progenitor cells). These cells and fibroblasts and/or muscle cells, viz. myoblasts, myofibroblasts, smooth muscle cells or the progenitors thereof, are, in the form of living cells, seeded onto a matrix or introduced into a matrix in order to yield the tissue construct following further treatment steps. The matrix is preferably a protein preparation, more particularly a fibrinogen preparation. Both the cells and the fibrinogen preparation can be obtained from a single blood sample from a patient. Apart from the preparation of bypass materials, prosthetic vascular graft, tissue patches, conduits and the like, the EOEC-containing EPC culture or suspension is suitable as means for cell transplantation.
    Type: Grant
    Filed: September 13, 2012
    Date of Patent: May 23, 2017
    Assignee: MEDIZINISCHE HOCHSCHULE HANNOVER (MHH)
    Inventors: Axel Haverich, Thomas Aper, Mathias Wilhelmi
  • Patent number: 9639977
    Abstract: A method of processing model data representing a body section with bilateral symmetry of a biological organism is proposed that comprises the steps of providing object imaging data representing the body section having one or more defect portions; calculating a longitudinal axis and a lateral axis of the body section based on mathematical analysis of the object imaging data; and determining a mirror plane based on the calculated longitudinal and lateral axes. Said mirror plane allows for reconstructing the one or more defect portions by mirroring one or more corresponding portions having no defects at the mirror plane.
    Type: Grant
    Filed: July 4, 2014
    Date of Patent: May 2, 2017
    Assignee: Medizinische Hochschule Hannover (MHH)
    Inventors: Hoen-oh Shin, Harald Essig
  • Publication number: 20170037440
    Abstract: The present invention relates to in vitro methods for producing Neisseria meningitidis capsular polysaccharides which have a defined length. The present invention also relates to compositions comprising at least one capsule polymerase, at least one donor carbohydrate and at least one acceptor carbohydrate, wherein the ratio of donor carbohydrate to acceptor carbohydrate is a ratio from 10:1 to 400:1. Moreover, the present invention provides truncated versions of the capsule polymerases of Neisseria meningitidis serogroups A and X. Also provided herein are pharmaceuticals, in particular vaccines, comprising the synthetic capsular polysaccharides of Neisseria meningitidis which have a defined length. Furthermore, the invention provides for methods for the production of said vaccines.
    Type: Application
    Filed: April 17, 2015
    Publication date: February 9, 2017
    Applicant: Medizinische Hochschule Hannover
    Inventors: Timm FIEBIG, Tim KEYS, Friedrich FREIBERGER, Angela ROMANOW, Andrea BETHE, Monika BERGER, Rita GERARDY-SCHAHN
  • Patent number: 9535071
    Abstract: The present disclosure provides methods and compositions that find use in facilitating a diagnosis of inflammatory liver disease in a subject. The methods and compositions generally involve detection of eotaxin-3 (E3) levels, either alone or with levels of eotaxin-1 (E1), and optionally, with levels of CCL22 and, further optionally, with levels of IL15. These levels can be used to facilitate a diagnosis of a liver disease of at least one of autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC), and primary sclerosing cholangitis (PSC), and/or to facilitate a differential diagnosis between AIH, PBC, and PSC. The methods and compositions of the present disclosure also find use in facilitating treatment decisions for a subject.
    Type: Grant
    Filed: September 6, 2013
    Date of Patent: January 3, 2017
    Assignees: The Governors of the University of Alberta, Medizinische Hochschule Hannover
    Inventors: Abdolamir Landi, Michael Houghton, D. Lorne Tyrrell, Tim Lankisch, Tobias Weismueller, Michael Manns
  • Patent number: 9499471
    Abstract: The present invention relates to a compound of formula (I) as defined herein.
    Type: Grant
    Filed: September 10, 2012
    Date of Patent: November 22, 2016
    Assignee: Medizinische Hochschule Hannover
    Inventors: Dietmar Manstein, Matthias Preller, Marcus Furch, Markus Kalesse, Nina Diaz-Gomez
  • Patent number: 9458200
    Abstract: The present invention relates to the use of particular macrocycles that are inhibitors of the proteasomic degradation of p27, in particular argyrin and derivatives thereof, for a treatment in a variety of conditions, such as the induction of immunotolerance, autoimmune diseases, bacterial infections, and proliferative diseases, such as cancers.
    Type: Grant
    Filed: June 23, 2009
    Date of Patent: October 4, 2016
    Assignees: Gottfried Wilhelm Leibniz Universität Hannover, Medizinische Hochschule Hannover, Helmholtz-Zentrum für Infektionsforschung GmbH
    Inventors: Markus Kalesse, Nisar Malek, Ronald Frank, Tobias Brodmann, Leila Bülow, Andreas Rentsch, Anna-Katharina Girbig, Ulrike Eggert
  • Patent number: 9388411
    Abstract: The present invention refers to inhibitors of microRNAs, particularly of microRNAs miR-212 and/or miR-132 for use in medicine, particularly in the diagnosis, treatment or prevention of cardiac disorders, e.g. cardiac hypertrophy-associated or autophagic disorders, and further refers to isolated nucleic acid molecules, particularly microRNAs miR-212 and/or miR-132 and related sequences, for use in medicine, particularly human medicine, more particularly in the diagnosis, treatment or prevention of disorders involving cardiac atrophy and/or dysfunctional autophagy, e.g. cardiac cachexia.
    Type: Grant
    Filed: September 6, 2012
    Date of Patent: July 12, 2016
    Assignees: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V., Medizinische Hochschule Hannover
    Inventors: Thomas Thum, Kamal Chowdhury, Ahmet Ucar, Shashi Kumar Gupta
  • Publication number: 20160095823
    Abstract: The present invention concerns compounds derived from the anaesthetic propofol that are useful as analgesics and methods of using the same. The compounds act as co-activators of strychnine-sensitive glycine receptors and may have greater activity at those glycine receptors than at GABAA.
    Type: Application
    Filed: November 24, 2015
    Publication date: April 7, 2016
    Applicants: The University of Liverpool, The University of Dundee, Medizinische Hochschule Hannover
    Inventors: Martin Leuwer, Gertrud Haeseler, Jeremy Lambert, Delia Belelli
  • Patent number: 9222074
    Abstract: The invention provides a process for producing a three-dimensional tissue by cultivating eucaryotic cells by introducing the cells into a matrix and cultivating the cells within the matrix in a cell culture medium within a cell culture vessel under controlled dissolved oxygen conditions of the cell culture medium. The matrix contains a support containing an optical oxygen sensor, which is an oxygen-sensitive dye, which upon irradiation with an excitation wavelength changes its emission characteristics in dependence on the dissolved oxygen concentration in the surrounding medium, including a dye phosphorescing upon irradiation of an excitation wavelength, which phosphorescence is quenched by dissolved oxygen.
    Type: Grant
    Filed: October 4, 2011
    Date of Patent: December 29, 2015
    Assignees: Medizinische Hochschule Hannover, Biomimetics Technologies, Inc.
    Inventors: Meir Israelowitz, Birgit Weyand, Peter Vogt, Kerstin Reimers, Herbert von Schroeder, Christoph Gille, Elmar Schmaelzlin
  • Patent number: 9192778
    Abstract: The invention provides a cochlea stimulator for implantation comprising optical fibers of which are coupled to an irradiation source that is controlled by a modulator to generate irradiation specific for a pre-determined range of sound-frequencies. The cochlea stimulator effects a frequency-specific activation of the organ of Corti needed for speech perception especially in noisy environment and more complex sounds. For imparting excitation signals which are generated by modulated pulsed laser irradiation conducted within an optical fiber in order to elicit nervous signals in residual functional organ of Corti sections, the auditory prosthesis preferably contains optical fibers which are dimensioned to terminate in end sections within the cochlea at different sites or sections of the organ of Corti. e.g. having different lengths for locating their end sections at different internal parts of the cochlea.
    Type: Grant
    Filed: January 30, 2009
    Date of Patent: November 24, 2015
    Assignees: MEDIZINISCHE HOCHSCHULE HANNOVER, LEIBNIZ UNIVERSITAT HANNOVER
    Inventors: Thomas Lenarz, Holger Lubatschowski, Guenter Reuter, Gentiana I. Wenzel, Hubert H. Lim, Wolfgang Ertmer
  • Patent number: 9186381
    Abstract: The present invention relates to the use of a compound which inhibits the activity of MKK4 as a medicament for the treatment of a patient suffering from an impaired liver function, to the use of a compound as a medicament for the treatment of liver failure, including acute/fulminant or chronic liver failure and/or for increasing the regeneration of liver tissue in a patient.
    Type: Grant
    Filed: April 10, 2012
    Date of Patent: November 17, 2015
    Assignees: Helmholtz Zentrum Fuer Infektionsforschung GmbH, Medizinische Hochschule Hannover
    Inventors: Lars Zender, Torsten Wuestefeld
  • Publication number: 20150219664
    Abstract: The present disclosure provides methods and compositions that find use in facilitating a diagnosis of inflammatory liver disease in a subject. The methods and compositions generally involve detection of eotaxin-3 (E3) levels, either alone or with levels of eotaxin-1 (E1), and optionally, with levels of CCL22 and, further optionally, with levels of IL15. These levels can be used to facilitate a diagnosis of a liver disease of at least one of autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC), and primary sclerosing cholangitis (PSC), and/or to facilitate a differential diagnosis between AIH, PBC, and PSC. The methods and compositions of the present disclosure also find use in facilitating treatment decisions for a subject.
    Type: Application
    Filed: September 6, 2013
    Publication date: August 6, 2015
    Applicant: Medizinische Hochschule Hannover
    Inventors: Abdolamir Landi, Michael Houghton, D. Lorne Tyrrell, Tobias Weismueller, Michael Manns
  • Patent number: 9066937
    Abstract: Epidermal lipoxygenase obtained from axolotl is utilized in pharmaceutical or cosmetic compositions. The compositions have use in wound healing, bone healing or conditioning of injured tissue, e.g. in wound dressings.
    Type: Grant
    Filed: May 28, 2010
    Date of Patent: June 30, 2015
    Assignee: Medizinische Hochschule Hannover
    Inventors: Peter Vogt, Bjoern Menger, Kerstin Reimers-Fadhlaoui