Patents Assigned to Medizinische Hochschule Hannover
  • Publication number: 20180224463
    Abstract: The present invention relates generally to methods for diagnosing the presence or the risk of development or the therapy control of spondyloarthritis (Spa), in particular, of ankylosing spondylitis (AS) and undifferentiated spondyloarthritis in a subject, in particular in mammals. In addition, the present invention relates to test kits for use in the diaposis of the presence or the risk of development, or for the therapy control of Spa, like AS and undifferentiated spondyloarthritis, in a subject. In particular, the present invention relates to a method for diagnosing the presence or the risk of development, or for the therapy control of Spa, like AS and undifferentiated spondyloarthritis, it a subject analysing for the presence of autoantibodies against CD74 and/or IKBKB in a subject. The presence of autoantibodies against CD74 and/or IKBKB is indicative for the presence or the risk of development, or for the therapy control of Spa, like AS and undifferentiated spondyloarthritis.
    Type: Application
    Filed: January 30, 2018
    Publication date: August 9, 2018
    Applicant: MEDIZINISCHE HOCHSCHULE HANNOVER
    Inventors: Niklas Thomas BAERLECKEN, Torsten WITTE
  • Publication number: 20180200504
    Abstract: A cochlear implant of a cochlear implant system is described. The cochlear implant comprises electrodes which are mechanically connected to one another and can be inserted in a row in the form of a spiral into a cochlea in order for auditory nerve receptors to be stimulated, a control circuit that can specifically apply electric pulses to the individual electrodes, and an energy source. The control circuit allows the electrodes to be fed in a pulsed manner with electric signals generated by a processor from the acoustic signals, and auditory nerve receptors adjacent to the electrodes to be stimulated. The electrodes are components of modules, each of which comprises its own decoder-and-control circuit for decoding module addresses and stimulation signals and generating electric pulses for the electrodes. Encoded module addresses and stimulation signals generated from acoustic signals are applied to inputs of the decoder-and-control circuit.
    Type: Application
    Filed: July 27, 2016
    Publication date: July 19, 2018
    Applicants: Medizinische Hochschule Hannover, Gottfried Wilhelm Leibniz Universitaet Hannover
    Inventors: Holger BLUME, Wolfgang ERTMER, Thomas LENARZ, Andrej KRAL
  • Patent number: 10010293
    Abstract: A method of processing magnetic resonance (MR) lung images creates a quantitative ventilation map of the lung, which is calculated from ventilation images. A step of determining ventilation frequency includes a frequency analysis of a time series of a quantitative lung dimension parameter which is characteristic for the dimension of the lung at the time of collecting the corresponding MR lung image. Creation of the quantitative ventilation map includes selecting a first group of ventilation images, which consists of expiration ventilation images collected at regular expiration phases of multiple ventilation periods, and a second group of ventilation images, which consists of inspiration ventilation images collected at regular inspiration phases of the multiple ventilation periods, and calculating the quantitative ventilation map from the first and second groups of ventilation images, wherein the quantitative ventilation map is adjusted with reference to the tidal volume of the lung.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: July 3, 2018
    Assignee: MEDIZINISCHE HOCHSCHULE HANNOVER
    Inventors: Andreas Voskrebenzev, Marcel Gutberlet, Jens Vogel-Claussen
  • Patent number: 9993249
    Abstract: The invention relates to a surgical device (100) designed to be inserted into a stump of a hollow organ (40) of a person or animal in order to prepare a circular anastomosis, wherein the device (100) is designed without a stapling unit for producing a surgical stapled scam, wherein the device (100) has an instrument shaft (120) having a handle section (121, 300) and, at the end of time instrument shaft (120) away from the handle section (121, 300), a head section (130) that is or can be coupled to the instrument shaft (120) by means of a detachable coupling (113), wherein the handle section (121, 300) is designed for a user to hold the device (100), wherein the head section (130) has at least one first molded body (109) and a counter-pressure plate (111) of a surgical circular stapling device (160) connected to the first molded body (109), wherein the surgical device has fu least one first molded body (109) and one second molded body (108) between the handle section and the counter-pressure plate, the second
    Type: Grant
    Filed: October 26, 2012
    Date of Patent: June 12, 2018
    Assignee: Medizinische Hochschule Hannover
    Inventor: Nikos Emmanouilidis
  • Patent number: 9952203
    Abstract: The present invention relates to a new binder molecule useful e.g. as an immune suppressor. In particular, it has been recognized that the UL11 protein of human the cytomegalovirus, binds to the CD45 molecule, potentially altering the immune system of an individual. In addition, the present invention relates to binder molecules, in particular, fusion molecules containing the CD45 binding domain of the UL11 protein in combination with a second molecule of interest for delivery of said molecule to cells expressing the CD45 molecule. Moreover, the present invention relates to pharmaceutical compositions comprising the UL11 protein of human cytomegalovirus, or derivatives or homologs thereof, or a nucleic acid sequence encoding the same.
    Type: Grant
    Filed: March 21, 2012
    Date of Patent: April 24, 2018
    Assignee: Medizinische Hochschule Hannover
    Inventors: Penelope Kay-Fedorov, Martin Messerle, Thomas F. Schulz, Lars Steinbrück, Ildar Gabaev
  • Patent number: 9952226
    Abstract: The present disclosure provides methods and compositions that find use in facilitating a diagnosis of inflammatory liver disease in a subject. The methods and compositions generally involve detection of eotaxin-3 (E3) levels, either alone or with levels of eotaxin-1 (E1), and optionally, with levels of CCL22 and, further optionally, with levels of IL15. These levels can be used to facilitate a diagnosis of a liver disease of at least one of autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC), and primary sclerosing cholangitis (PSC), and/or to facilitate a differential diagnosis between AIH, PBC, and PSC. The methods and compositions of the present disclosure also find use in facilitating treatment decisions for a subject.
    Type: Grant
    Filed: November 21, 2016
    Date of Patent: April 24, 2018
    Assignees: Medizinische Hochschule Hannover, The Governors of the University of Alberta
    Inventors: Abdolamir Landi, Michael Houghton, D. Lorne Tyrrell, Tim Lankisch, Tobias Weismueller, Michael Manns
  • Patent number: 9915667
    Abstract: Provided herein are methods for diagnosing the presence or the risk of development, or for the therapy control of vasculitis, in particular of large vessel vasculitis, like giant-cell arteritis (GCA), polymyalgia rheumatica (PMR), and Takayasu's arteritis, in a subject analyzing for the presence of antibodies against ferritin, in particular heavy chain ferritin or immunoreactive peptides thereof or ferritin analog protein, preferably bacterial ferritin analog protein, or immunoreactive peptides thereof, in a subject. In addition, test kits for use in the diagnosis of the presence or the risk of development, or for the therapy control of vasculitis, in particular of large vessel vasculitis, like GCA, PMR and Takayasu's arteritis, in a subject are also provided.
    Type: Grant
    Filed: January 27, 2012
    Date of Patent: March 13, 2018
    Assignee: MEDIZINISCHE HOCHSCHULE HANNOVER
    Inventors: Torsten Witte, Niklas Thomas Baerlecken
  • Patent number: 9867956
    Abstract: The invention is related to a medical device (1) for conducting a medical examination and/or intervention within a human or animal body, the medical device (1) comprising a handle (2) and a curved guiding bar (3) connected to the handle (2), the guiding bar (3) comprising a guiding duct (4) adapted for guiding a medical instrument (5) from the handle area to a distal end (7) of the guiding bar (3) which is distant from the handle (2), the guiding bar (3) comprising on its distal end (7) a first camera (6) which is integrated within the guiding bar (3) or attached to the guiding bar (3), whereby the first camera (6) is arranged and adjusted for capturing an area (8) in front of the distal end (7) of the guiding bar (3).
    Type: Grant
    Filed: June 15, 2012
    Date of Patent: January 16, 2018
    Assignee: Medizinische Hochschule Hannover
    Inventor: Konstantinos Raymondos
  • Patent number: 9782350
    Abstract: The present invention relates in a first aspect to a method of coating surfaces of substrates with a lattice-like structure. In particular, the present invention relates to an in vitro method of coating surfaces by binding of epsin or a fragment thereof on the surface and, thereafter, binding of a compound forming the lattice like structure, in particular, binding of the clathrin heavy chain, to the epsin bound on the surface, thus, obtaining a coated substrate having a lattice like structure on the surface. In another aspect, the present invention relates to an in vitro method of producing nanometer-sized liposomes having a clathrin structure on its surface. In addition, substrates, like elements or devices, with coated surfaces having a lattice-like structure on the surface are provided obtainable by a method according to the present invention.
    Type: Grant
    Filed: February 6, 2013
    Date of Patent: October 10, 2017
    Assignee: MEDIZINISCHE HOCHSCHULE HANNOVER
    Inventors: Philip Dannhuser, Ernst Ungewickell
  • Publication number: 20170274021
    Abstract: The method for preparing a tissue construct for medical purposes uses endothelial progenitor cells (EPC) which have not been passaged multiple times and have a content of EOEC (early outgrowth endothelial progenitor cells) and LOEC (late outgrowth endothelial progenitor cells). These cells and fibroblasts and/or muscle cells, viz. myoblasts, myofibroblasts, smooth muscle cells or the progenitors thereof, are, in the form of living cells, seeded onto a matrix or introduced into a matrix in order to yield the tissue construct following further treatment steps. The matrix is preferably a protein preparation, more particularly a fibrinogen preparation. Both the cells and the fibrinogen preparation can be obtained from a single blood sample from a patient. Apart from the preparation of bypass materials, prosthetic vascular graft, tissue patches, conduits and the like, the EOEC-containing EPC culture or suspension is suitable as means for cell transplantation.
    Type: Application
    Filed: April 19, 2017
    Publication date: September 28, 2017
    Applicant: MEDIZINISCHE HOCHSCHULE HANNOVER (MHH)
    Inventors: Axel HAVERICH, Thomas APER, Mathias WILHELMI
  • Patent number: 9765303
    Abstract: The present invention relates to a method for the production of differentiated respiratory epithelial cells comprising: (a) providing a cell population comprising or consisting of precursor cells of respiratory epithelial cells; (b) culturing the cell population of (a) in culture medium to which keratinocyte growth factor has been added; wherein the cultured cell population is supplemented with a glucocorticoid, a cAMP analog and a cAMP elevating agent and wherein said supplementation is either simultaneously with the addition of keratinocyte growth factor in step (b) or prior or subsequently to the addition of keratinocyte growth factor in step (b), thereby differentiating said precursor cells into respiratory epithelial cells.
    Type: Grant
    Filed: February 3, 2012
    Date of Patent: September 19, 2017
    Assignee: MEDIZINISCHE HOCHSCHULE HANNOVER
    Inventors: Ulrich Martin, Christina Mauritz
  • Publication number: 20170203509
    Abstract: The invention relates to a method for manufacturing a component (10) by a generative manufacturing process, wherein the component is entirely or partially produced from a liquid raw material (12), characterised in that the component is entirely or partially produced from a liquid raw material (12) that can solidify when heated, the raw material is discharged in liquid form into a manufacturing zone (1) and heated and hence solidified by a computer-controlled, targeted light spot, in that the point of incidence of a light beam (8) from a light beam source is continuously and/or gradually modified relative to the manufacturing zone (1).
    Type: Application
    Filed: July 17, 2015
    Publication date: July 20, 2017
    Applicant: MEDIZINISCHE HOCHSCHULE HANNOVER
    Inventors: Jan STIEGHORST, Theodor DOLL
  • Patent number: 9662068
    Abstract: The invention is related to a medical device for conducting a medical examination and/or intervention within a human or animal body the medical device (1) comprising an elongate body (2) which is designed for introduction into an orifice (15) of the human or animal body the elongate body (2) comprising a distal end (3), which is on the front side of the elongate body during introduction into the orifice (15), of the human or animal body and a proximal end (4) on the opposite side, wherein the elongate body is a hollow body comprising a reception chamber (8) in its interior, which reception chamber (8) is arranged for reception of a human finger (9), characterized in that one or more guiding elements (5, 21) for guiding a medical examination and/or intervention component (6) are located on or in the elongate body and at least one image gathering device (7), which is arranged for gathering of images in front of the distal end (3) of the elongate body (2), is arranged on or in the elongate body (2).
    Type: Grant
    Filed: January 27, 2012
    Date of Patent: May 30, 2017
    Assignee: Medizinische Hochschule Hannover
    Inventor: Konstantinos Raymondos
  • Patent number: 9655931
    Abstract: The method for preparing a tissue construct for medical purposes uses endothelial progenitor cells (EPC) which have not been passaged multiple times and have a content of EOEC (early outgrowth endothelial progenitor cells) and LOEC (late outgrowth endothelial progenitor cells). These cells and fibroblasts and/or muscle cells, viz. myoblasts, myofibroblasts, smooth muscle cells or the progenitors thereof, are, in the form of living cells, seeded onto a matrix or introduced into a matrix in order to yield the tissue construct following further treatment steps. The matrix is preferably a protein preparation, more particularly a fibrinogen preparation. Both the cells and the fibrinogen preparation can be obtained from a single blood sample from a patient. Apart from the preparation of bypass materials, prosthetic vascular graft, tissue patches, conduits and the like, the EOEC-containing EPC culture or suspension is suitable as means for cell transplantation.
    Type: Grant
    Filed: September 13, 2012
    Date of Patent: May 23, 2017
    Assignee: MEDIZINISCHE HOCHSCHULE HANNOVER (MHH)
    Inventors: Axel Haverich, Thomas Aper, Mathias Wilhelmi
  • Patent number: 9639977
    Abstract: A method of processing model data representing a body section with bilateral symmetry of a biological organism is proposed that comprises the steps of providing object imaging data representing the body section having one or more defect portions; calculating a longitudinal axis and a lateral axis of the body section based on mathematical analysis of the object imaging data; and determining a mirror plane based on the calculated longitudinal and lateral axes. Said mirror plane allows for reconstructing the one or more defect portions by mirroring one or more corresponding portions having no defects at the mirror plane.
    Type: Grant
    Filed: July 4, 2014
    Date of Patent: May 2, 2017
    Assignee: Medizinische Hochschule Hannover (MHH)
    Inventors: Hoen-oh Shin, Harald Essig
  • Publication number: 20170037440
    Abstract: The present invention relates to in vitro methods for producing Neisseria meningitidis capsular polysaccharides which have a defined length. The present invention also relates to compositions comprising at least one capsule polymerase, at least one donor carbohydrate and at least one acceptor carbohydrate, wherein the ratio of donor carbohydrate to acceptor carbohydrate is a ratio from 10:1 to 400:1. Moreover, the present invention provides truncated versions of the capsule polymerases of Neisseria meningitidis serogroups A and X. Also provided herein are pharmaceuticals, in particular vaccines, comprising the synthetic capsular polysaccharides of Neisseria meningitidis which have a defined length. Furthermore, the invention provides for methods for the production of said vaccines.
    Type: Application
    Filed: April 17, 2015
    Publication date: February 9, 2017
    Applicant: Medizinische Hochschule Hannover
    Inventors: Timm FIEBIG, Tim KEYS, Friedrich FREIBERGER, Angela ROMANOW, Andrea BETHE, Monika BERGER, Rita GERARDY-SCHAHN
  • Patent number: 9535071
    Abstract: The present disclosure provides methods and compositions that find use in facilitating a diagnosis of inflammatory liver disease in a subject. The methods and compositions generally involve detection of eotaxin-3 (E3) levels, either alone or with levels of eotaxin-1 (E1), and optionally, with levels of CCL22 and, further optionally, with levels of IL15. These levels can be used to facilitate a diagnosis of a liver disease of at least one of autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC), and primary sclerosing cholangitis (PSC), and/or to facilitate a differential diagnosis between AIH, PBC, and PSC. The methods and compositions of the present disclosure also find use in facilitating treatment decisions for a subject.
    Type: Grant
    Filed: September 6, 2013
    Date of Patent: January 3, 2017
    Assignees: The Governors of the University of Alberta, Medizinische Hochschule Hannover
    Inventors: Abdolamir Landi, Michael Houghton, D. Lorne Tyrrell, Tim Lankisch, Tobias Weismueller, Michael Manns
  • Patent number: 9499471
    Abstract: The present invention relates to a compound of formula (I) as defined herein.
    Type: Grant
    Filed: September 10, 2012
    Date of Patent: November 22, 2016
    Assignee: Medizinische Hochschule Hannover
    Inventors: Dietmar Manstein, Matthias Preller, Marcus Furch, Markus Kalesse, Nina Diaz-Gomez
  • Patent number: 9458200
    Abstract: The present invention relates to the use of particular macrocycles that are inhibitors of the proteasomic degradation of p27, in particular argyrin and derivatives thereof, for a treatment in a variety of conditions, such as the induction of immunotolerance, autoimmune diseases, bacterial infections, and proliferative diseases, such as cancers.
    Type: Grant
    Filed: June 23, 2009
    Date of Patent: October 4, 2016
    Assignees: Gottfried Wilhelm Leibniz Universität Hannover, Medizinische Hochschule Hannover, Helmholtz-Zentrum für Infektionsforschung GmbH
    Inventors: Markus Kalesse, Nisar Malek, Ronald Frank, Tobias Brodmann, Leila Bülow, Andreas Rentsch, Anna-Katharina Girbig, Ulrike Eggert
  • Patent number: 9388411
    Abstract: The present invention refers to inhibitors of microRNAs, particularly of microRNAs miR-212 and/or miR-132 for use in medicine, particularly in the diagnosis, treatment or prevention of cardiac disorders, e.g. cardiac hypertrophy-associated or autophagic disorders, and further refers to isolated nucleic acid molecules, particularly microRNAs miR-212 and/or miR-132 and related sequences, for use in medicine, particularly human medicine, more particularly in the diagnosis, treatment or prevention of disorders involving cardiac atrophy and/or dysfunctional autophagy, e.g. cardiac cachexia.
    Type: Grant
    Filed: September 6, 2012
    Date of Patent: July 12, 2016
    Assignees: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V., Medizinische Hochschule Hannover
    Inventors: Thomas Thum, Kamal Chowdhury, Ahmet Ucar, Shashi Kumar Gupta