Abstract: The invention relates to a method for the prediction of the risk potential and/or diagnosis of cancerous diseases or inflammatory intestinal diseases, whereby a DNA sample is tested for the presence of polymorphic UGT1A7 allele. A positive result for a mutation is a positive indication of a sensitivity to cancerous diseases. A prediction of sensitivity to an inflammatory intestinal disease can similarly be made. A PCR amplification of the exon 1, using the DNA sample with subsequent sequence analysis is carried out in the method and the determined sequence compared with that of the wild type and the polymorphic allele. The presence or lack of mutations is monitored by sequencing the corresponding cDNA using automated fluorescent dye sequencing. The test arrangement for requires genetic detection reagents, namely the required primer or cDNAs, on a stationary support in a pre-prepared arrangement or sequence for reading off the results. The recombinant UGT1A7 enzymes are also used for therapeutic purposes.

Abstract: The present invention concerns compounds derived from the anaesthetic propofol that are useful as analgesics and methods of using the same. The compounds act as co-activators of strychnine-sensitive glycine receptors and may have greater activity at those glycine receptors than at GABAA.

Abstract: A cutting device (1) for cutting bone tissue (3), which is particularly intended for correcting malpositions, and which enables a segment of the bone tissue (3) to be cut along a predetermined cut surface (5). The cutting device (1) produces a high pressure fluid jet (2) which is guided by a control program stored in a control unit (4) to produce a cut surface (5) having a desired configuration, for example, a circular arc shape. The resulting bone parts (6, 7), created in this manner, can be fixed in a corrective position (8) with little effort and without significant loss of material. A collector (9), which is equipped with a supply line (14) for supplying a rinsing liquid and with a suction line (13), is provided for collecting the fluid from the fluid jet (2). Collector (9) simultaneously serves to reduce the energy remaining in the high-pressure fluid jet (2).