Abstract: A method can be provided for analyzing a fluidic sample with dispersed particles. Using such exemplary method, it is possible to irradiate the sample with light, so that the photons of the light transfer momentum to the particles. It is also possible to measure at least one property of the particles that is altered by the momentum transfer. The light can be a propagating beam with an intensity distribution that has gradients pointing to more than one point within each plane normal to the direction of propagation, while varying steadily along the direction of propagation, and/or a 3D vortex trap beam that is configured to confine the particles in a three-dimensional volume by means of high-intensity gradients. An exemplary device can also be provided (e.g., for performing the method), comprising a chamber for holding a sample that is elongate along an axis and configured to pass a beam of light along the axis.

Abstract: Provided is a method for determining, in a sample, enrichments of a first and a second stable-labeled tracer of a target substance including glucose, the first tracer and the second tracer having the same or similar chemical structure as the target substance, the method including: ionizing the first tracer, the second tracer and the target substance of the sample; measuring intensities of ions deriving from the target substance, the first tracer and the second tracer using a mass analyzer; calculating an enrichment of the first tracer from a first ratio of intensity of the ions deriving from the first tracer to the intensity of the ions deriving from the target substance employing a first calibration curve independent of enrichments of each of the second tracer; wherein the mass analyzer is operated so as to resolve an ion peak deriving from a tracer and having a width ?(m/z) at half maximum peak height equal to or smaller than 1×10?2.

Abstract: The present invention relates to a polypeptide comprising at least one signaling domain and a potassium sensor which is capable of binding K+ and the first signaling domain is capable of generating a detectable signal upon binding of K+ to the potassium sensor. The invention also relates to a polynucleotide encoding said polypeptide and the use of the polypeptide in various applications for the detection of K+.

Abstract: A placement aid for placing a catheter and a sensor wire into a body including a replacement device arranged in an interchangeable and replaceable manner having a main body, a placement needle, a catheter and a sensor wire. The placement needle is arranged within the catheter so that a tip of the placement needle protrudes from an end of the catheter along a puncturing direction and penetrates the skin when the catheter is inserted along the puncturing direction to generate a skin opening through which the catheter can be guided up to a subcutaneous final position. The sensor wire is arranged in the placement needle when the catheter is inserted along the puncturing direction and when the subcutaneous final position of the catheter is reached, the placement needle can be withdrawn from the catheter against the puncturing direction and the sensor wire remains in the catheter.

Abstract: The invention relates to a composite material that comprises at least one magnesium component, whereby the magnesium component consists of pure magnesium or a magnesium-calcium alloy or a magnesium-calcium-X alloy, whereby X is another biodegradable element. The composite material also contains at least one organic anti-infective agent having a solubility in water at room temperature of less than 10 grams per liter.

Abstract: The invention concerns a storage device (23, 45) for storing receptacles (10), preferably cryo-vials (10), in a carrier structure (3), the storage device (23, 45) comprising pockets (20) each for holding an individual receptacle (10), wherein the pockets (20) are connected one above the other in direction of a common longitudinal axis (59) and the storage device (23, 45) being provided with openings for inserting and retrieving receptacles (10) into and from said pockets (20) in longitudinal direction (60) and/or in lateral direction (61). Also a storage and storage-access system according to the invention is indicated.

Abstract: An arrangement for administering a predetermined amount of a substance into an organism is presented. The arrangement includes a member adapted to provide information indicative of a tissue resistance against flow of a fluid containing the substance upon administration into the tissue and a controller adapted to adjust an administration characteristic of the fluid based on the information such as to achieve an intended absorption rate of the substance.

Abstract: A medical apparatus for supplying a medication fluid into an organism and for detecting a substance of the organism is disclosed. The medical apparatus has a casing, cannula, and an insertion needle. The casing has a chamber accommodating the medication fluid and an opening in fluid communication with the chamber. The cannula has a lumen in fluid communication with the chamber. The insertion needle has a receptacle. A portion of the insertion needle is removably arrangeable within the lumen. The receptacle is configured to at least partially receive a sensor system for detecting the substance of the organism. A seal is adapted to annularly sealingly surround a portion of the sensor system when the insertion needle is removed from the opening and the portion of the sensor system is arranged in the opening.

Abstract: The invention relates to a composite material that comprises at least one magnesium component, whereby the magnesium component consists of pure magnesium or a magnesium-calcium alloy or a magnesium-calcium-X alloy, whereby X is another biodegradable element. The composite material also contains at least one organic anti-infective agent having a solubility in water at room temperature of less than 10 grams per liter.

Abstract: A medical apparatus for supplying a medication fluid into an organism and for detecting a substance of the organism is disclosed. The medical apparatus has a casing, cannula, and an insertion needle. The casing has a chamber accommodating the medication fluid and an opening in fluid communication with the chamber. The cannula has a lumen in fluid communication with the chamber. The insertion needle has a receptacle. A portion of the insertion needle is removably arrangeable with the lumen. The receptacle is configured to at least partially receive a sensor system for detecting the substance of the organism. A seal is adapted to annularly sealingly surround a portion of the sensor system when the insertion needle is removed from the opening and the portion of the sensor system is arranged in the opening.

Abstract: Non-mercaptalbumin-2 is used as a biomarker for diagnosing a medical condition associated with oxidative stress. A method for diagnosing a condition associated with oxidative stress includes determining the redox state of albumin at the cysteine residue at sequence position 34; quantifying the level of non-mercaptalbumin-2 present, non-mercaptalbumin-2 representing the albumin fraction irreversibly oxidized at cysteine 34; and comparing the result to a control level, wherein an elevated level of non-mercaptalbumin-2 as compared to the control level is indicative of the condition associated with oxidative stress.

Abstract: An arrangement for administering a predetermined amount of a substance into an organism is presented. The arrangement includes a member adapted to provide information indicative of a tissue resistance against flow of a fluid containing the substance upon administration into the tissue and a controller adapted to adjust an administration characteristic of the fluid based on the information such as to achieve an intended absorption rate of the substance.

Abstract: A device for delivery of glucose-regulating medication, particularly insulin, depending on the measured tissue glucose concentration, having a sensor for measuring the glucose concentration in tissue fluid, possibly a unit for removing fluid from subcutaneous tissue, as well as a container for the glucose-regulating medications, having a unit for subcutaneous delivery of the glucose-regulating medications, and having a unit connected to the glucose sensor for regulating the quantity of the glucose-regulating medication to be delivered depending on the measured tissue glucose concentrations. The device simulates the function of the natural pancreas and is constructed small and compact.

Abstract: An apparatus for determining a thickness of a layer of fat of an organism, the apparatus comprising a plurality of electromagnetic radiation sources adapted for illuminating the layer of fat with a plurality of pulses of electromagnetic radiation, at least one electromagnetic radiation detector adapted for detecting detection signals indicative of the pulses of electromagnetic radiation after transmission through the layer of fat, and a determining unit adapted for determining a plurality of values of the thickness of the layer of fat based on an analysis of a plurality of ratios between the detection signals, wherein only those values are used for calculating an average thickness of the layer of fat which values result in deviations from the average thickness of less than a predetermined threshold value.