Patents Assigned to Medizinisches Laserzentrum Luebeck GmbH
  • Patent number: 10682052
    Abstract: The invention relates to an interferometric method, in which the light scattered by an object is imaged onto an electronic camera, wherein a sample light component is assigned to scattering sites on a sectional face in the interior of the object. This sample light component can be separated from the contributions of the other sample light components by processing of the camera image and leads to a sectional image. A particular advantage of the invention lies in the fact that multiple parallel sectional faces can be exposed sequentially at predetermined intervals from each other in the interior of the object. Such a sequence of sectional images can be used to calculate a solid model of the object.
    Type: Grant
    Filed: August 9, 2016
    Date of Patent: June 16, 2020
    Assignees: Medizinisches Laserzentrum Luebeck GmbH, Thorlabs GmbH
    Inventors: Peter Koch, Gesa Franke, Hendrik Spahr, Helge Sudkamp, Gereon Hüttmann, Dierck Hillmann, Reginald Birngruber
  • Patent number: 10219946
    Abstract: A method and a system for detecting a movement of a surface on an irradiated sample involves a light source for irradiating the surface with a coherent light beam, a detector for detecting variations caused by the movement in a speckle pattern produced by reflections of the light beam at the surface, selecting a single speckle from the speckle pattern, and detecting the variations at the selected speckle.
    Type: Grant
    Filed: January 20, 2012
    Date of Patent: March 5, 2019
    Assignee: Medizinisches Laserzentrum Luebeck GmbH
    Inventors: Andreas Fritz, Ralf Brinkmann
  • Publication number: 20180235461
    Abstract: The invention relates to an interferometric method, in which the light scattered by an object is imaged onto an electronic camera, wherein a sample light component is assigned to scattering sites on a sectional face in the interior of the object. This sample light component can he separated from the contributions of the other sample light components by processing of the camera image and leads to a sectional image. A particular advantage of the invention lies in the fact that multiple parallel sectional faces can be exposed sequentially at predetermined intervals from each other in the interior of the object. Such a sequence of sectional images can be used to calculate a solid model of the object. The invention is applicable in particular to the live retina and allows a three-dimensional retina scan within a few seconds with a cost-effective and, if necessary, hand-held device. Application options are in the fields of ophthalmology and in biometry.
    Type: Application
    Filed: August 9, 2016
    Publication date: August 23, 2018
    Applicants: Thorlabs GmbH, Medizinisches Laserzentrum Lübeck GmbH
    Inventors: Peter KOCH, Gesa FRANKE, Hendrik SPAHR, Helge SUDKAMP, Gereon HÜTTMANN, Dierck HILLMANN, Reginald BIRNGRUBER
  • Publication number: 20150011983
    Abstract: A method and a system for detecting a movement of a surface on an irradiated sample involves a light source for irradiating the surface with a coherent light beam, a detector for detecting variations caused by the movement in a speckle pattern produced by reflections of the light beam at the surface, selecting a single speckle from the speckle pattern, and detecting the variations at the selected speckle.
    Type: Application
    Filed: January 20, 2012
    Publication date: January 8, 2015
    Applicant: Medizinisches Laserzentrum Luebeck GmbH
    Inventors: Andreas Fritz, Ralf Brinkmann
  • Patent number: 8774904
    Abstract: A device for examining or treating living tissue by means of local heating of the tissue by absorbing electromagnetic radiation, with at least one radiation source emitting electromagnetic radiation, a control unit for controlling the irradiation parameters of the radiation source, and at least one FD-OCT apparatus with a light source emitting a measurement light for illuminating that tissue region in which the electromagnetic radiation is absorbed by the tissue, characterized by a computational unit for carrying out the following steps: determining the depth-resolved tissue velocity in the radiation direction of the measurement light at a predetermined measurement point of the tissue from the phase information from the FD-OCT interference light, integrating the established tissue velocity over time, differentiating the calculated time integral with respect to space, and displaying the spatial derivative as a function of space and time and/or feeding the spatial derivative as a function of space and time to a
    Type: Grant
    Filed: April 16, 2011
    Date of Patent: July 8, 2014
    Assignee: Medizinisches Laserzentrum Luebeck GmbH
    Inventors: Reginald Birngruber, Ralf Brinkmann, Gereon Huettmann, Heike Mueller
  • Patent number: 8480660
    Abstract: An apparatus for the treatment of biological, in particular living tissue comprising a treatment laser device 1 for generating a pulsed treatment radiation directed on to a target tissue, in an embodiment additionally including a measurement laser device 2, 3 for generating a pulsed measurement radiation directed on to the target tissue of lower energy and shorter pulse duration than the treatment radiation, a detector device 4 for measuring pressure transients induced by the measurement radiation and a control device 6 for controlling the treatment radiation in dependence on the pressure transients evaluated in respect of a tissue change, wherein a regulating or control algorithm for controlling the treatment radiation is formed from the pressure transients.
    Type: Grant
    Filed: September 9, 2009
    Date of Patent: July 9, 2013
    Assignee: Medizinisches Laserzentrum Luebeck GmbH
    Inventor: Ralf Brinkmann
  • Publication number: 20130102894
    Abstract: A device for examining or treating living tissue by means of local heating of the tissue by absorbing electromagnetic radiation, with at least one radiation source emitting electromagnetic radiation, a control unit for controlling the irradiation parameters of the radiation source, and at least one FD-OCT apparatus with a light source emitting a measurement light for illuminating that tissue region in which the electromagnetic radiation is absorbed by the tissue, characterized by a computational unit for carrying out the following steps: determining the depth-resolved tissue velocity in the radiation direction of the measurement light at a predetermined measurement point of the tissue from the phase information from the FD-OCT interference light, integrating the established tissue velocity over time, differentiating the calculated time integral with respect to space, and displaying the spatial derivative as a function of space and time and/or feeding the spatial derivative as a function of space and time to a
    Type: Application
    Filed: April 16, 2011
    Publication date: April 25, 2013
    Applicant: MEDIZINISCHES LASERZENTRUM LUEBECK GMBH
    Inventors: Reginald Birngruber, Ralf Brinkmann, Gereon Huettmann, Heike Mueller
  • Patent number: 7836894
    Abstract: This invention relates to a method for operation of an irradiation laser whereby laser pulse sequences or pulses of varying length are modified during application such that the comparability of recorded transients is retained.
    Type: Grant
    Filed: January 9, 2006
    Date of Patent: November 23, 2010
    Assignee: Medizinisches Laserzentrum Luebeck GmbH
    Inventors: Ralf Brinkmann, Georg Schuele
  • Publication number: 20100292539
    Abstract: An apparatus for optical coherence tomography has a broadband light source with a short coherence length, an optical fiber that guides the light from the light source to a focusing optics, and a graded-index optics arranged between the optical fiber and the focusing optics with two opposite parallel flat sides, that is contacted on its first flat side by the optical fiber forming an irradiation point guiding light to the graded-index optics and having a pitch of N/8, N being a natural number that cannot be divided by 4. A first structure for light reflection is arranged on the first flat side of the graded-index optics adjacent to the irradiation point, and a second structure for beam splitting is arranged on the second flat side of the graded-index optics. The focusing optics are designed for focusing the light transmitted by the second structure essentially at right angles to the flat sides of the graded-index optics.
    Type: Application
    Filed: May 14, 2010
    Publication date: November 18, 2010
    Applicant: Medizinisches Laserzentrum Luebeck GmbH
    Inventors: Eva Lankenau, Tim Bonin, Gereon Huettmann
  • Patent number: 7357570
    Abstract: A method and device for determining the temperature of a sample, wherein a probing light beam is directed onto the sample whereby at least two partial beams of the probing light pass through paths of different lengths inside the sample by backscattering or reflecting the beams from at least two different depths in the sample, returning the partial beams to an analysis unit, and producing an interference pattern in the analysis unit by means of an interferometric device which uses one light beam as a reference for evaluating the interference pattern in an evaluating unit, wherein the signal intensity of the partial beam is determined counter to the optical path and the temperature displacement and temperature of the sample are determined by the temperature adjustment of the signal intensity.
    Type: Grant
    Filed: January 11, 2004
    Date of Patent: April 15, 2008
    Assignee: Medizinisches Laserzentrum Luebeck GmbH
    Inventor: Georg Schuele
  • Patent number: 6748128
    Abstract: The device serves for changing the length of a running path of an electromagnetic wave. It comprises a wave guide which is wound onto a core. The core is formed in two parts, wherein the distance of the core parts to one another is changeable in order to extend the wave length in a defined manner.
    Type: Grant
    Filed: July 20, 2001
    Date of Patent: June 8, 2004
    Assignee: Medizinisches Laserzentrum Lübeck GmbH
    Inventors: Peter Koch, Christian Scholz, Ralf Engelhardt
  • Patent number: 6671043
    Abstract: A process and an apparatus preferably used during the photocagulation of the fundus of human eyes or animals measures density fluctuations caused by pulsed irradiation, such as a laser irradiation source, on a material. A wherein a measuring signal is acoustically or optically detected. The change of the intensity and/or of the time slope of the measuring signal resulting from the irradiation of a specific material point is detected. A linear thermo-elastic signal fraction is removed from the measuring signal.
    Type: Grant
    Filed: July 12, 2000
    Date of Patent: December 30, 2003
    Assignee: Medizinisches Laserzentrum Luebeck GmbH
    Inventor: Gereon Huettman
  • Patent number: 6341870
    Abstract: The device serves the change of the length of the running path of an electromagnetic wave, and specifically of a light beam between the emitter and receiver. It comprises two oppositely lying reflection means between which the beam is reflected, as well as a means for changing the distance of these reflection means. The reflection means are arranged at an angle &bgr; to one another which lies between 0° and 45° so that the incident beam is thrown to and fro several times between the reflection means, until it is finally congruently thrown back.
    Type: Grant
    Filed: May 26, 2000
    Date of Patent: January 29, 2002
    Assignee: Medizinisches Laserzentrum Luebeck GmbH
    Inventors: Peter Koch, Christian Scholz, Ralf Engelhardt, Stefan Kubasiak
  • Patent number: 6234633
    Abstract: A method for the topographic display of interior surfaces of an object, for example, leakages on vessels of biological material by means of fluorescence angiography, in the case of which fluorescence images are produced in several planes of different depths and a fluorescent segmental chart is obtained therefrom.
    Type: Grant
    Filed: November 1, 1999
    Date of Patent: May 22, 2001
    Assignee: Medizinisches Laserzentrum Luebeck GmbH
    Inventors: Reginald Birngruber, Joachim Noack, Ursula Schmidt-Erfurth