Abstract: Disclosed are methods for sterilizing cyanoacrylate prepolymer compositions under visible light irradiation conditions wherein the prepolymer remains in polymerizable form after sterilization.

Abstract: A cyanoacrylate adhesive is applied to non-suturable, non-sterile wound surfaces to protect and/or treat such surfaces, to promote wound healing and to retard infection of the wound.

Abstract: Disclosed are cyanoacrylate compositions comprising a cyanoacrylate prepolymer and an encapsulated temperature sensitive indicator. These compositions provide for in situ formation of an polymeric cyanoacrylate film on mammalian skin which can be used to monitor the surface skin temperature of the mammal.

Abstract: Disclosed are methods for sterilizing cyanoacrylate prepolymer compositions under E-beam irradiation conditions wherein the prepolymer remains in polymerizable form after sterilization.

Abstract: Antimicrobial cyanoacrylate compositions are applied to suturable wound surfaces to close the wound surface.

Abstract: Alkyl cyanoacrylate compositions comprising at least one alkyl cyanoacrylate, a biocompatible plasticizer (preferably an acyl trialkyl citrate wherein the acyl group contains from 2 to 4 carbon atoms and each alkyl group contains from 4 to 6 carbon atoms), and SO2 as an anionic polymerization inhibitor are provided. These compositions are suitable for topical application to human skin.

Abstract: Disclosed are biocompatible prepolymer compositions comprising a compatible antimicrobial agent and, in particular, a compatible iodine containing antimicrobial agent. These compositions provide for in situ formation of an antimicrobial polymeric film on mammalian skin.

Abstract: Disclosed are kits of parts comprising a first container comprising a cyanoacrylate composition and a second container comprising a compatible antimicrobial agent and, in particular, a compatible iodine containing antimicrobial agent. Mixture of these compositions provide for in situ formation of an antimicrobial polymeric cyanoacrylate film on mammalian skin.

Abstract: Disclosed are cyanoacrylate compositions comprising a compatible antimicrobial agent and, in particular, a compatible iodine containing antimicrobial agent. These compositions provide for in situ formation of an antimicrobial polymeric cyanoacrylate film on mammalian skin.

Abstract: Methods and compositions for encapsulated polymeric gels swollen with nonaqueous reactive materials are provided. The methods include gel synthesis, swelling of a gel precursor with a first nonaqueous reactive material, and encapsulation of the swollen gel with a second nonaqueous reactive material. Gels precursors may be synthesized from crosslinking polymers, or alternatively, may be formed by crosslinking and polymerizing a monomer starting material. An accelerator may be utilized to facilitate swelling of the gel precursor with the first nonaqueous reactive material. Foams and composites may also be swollen with the first nonaqueous reactive material. The swollen gel is then contacted with a second nonaqueous reactive material such that an encapsulation layer is formed thereby. The encapsulated gels may be stored for subsequent use.

Abstract: Disclosed are methods for the application of a cyanoacrylate/anti-microbial composition over mammalian skin surfaces to peri-wound and peri-mucosal areas. The composition can also be applied over medicament that has been applied onto the skin surface.

Abstract: Disclosed are mixed alkyl cyanoacrylate compositions which are specifically formulated for topical application onto intact or broken human skin, preferably without the addition of a plasticizing agent to the composition.

Abstract: A cyanoacrylate ester composition comprising a corticosteroid is applied to skin lesions associated with dermatosis or dermatitis to protect and/or treat such lesions.

Abstract: Disclosed are methods for draping a surgical site prior to surgery. Specifically, the methods of this invention involve the in situ formation of a cyanoacrylate polymeric drape on the skin surface of a patient peripheral to the surgical site. Surgery is then conducted at the surgical site.

Abstract: A responsive polymer network exhibiting the property of reversible gelation in response to a change in an environmental stimulus is provided. The aqueous solution of the network polymer, comprises about 0.01 to 20 wt % by weight of a responsive component and about 0.01 to 20 wt % by weight of a structural component capable of supporting and interacting with the responsive component. The aqueous composition exhibits at least a five-fold increase in viscosity upon gelation. The gelation may be triggered by a change in an environmental stimulus, such as temperature, pH and ionic strength.

Abstract: System for delivery of a biologically active substance into an environment. First and second chambers are separated by a moveable partition. The first chamber includes a polymer gel network which undergoes a volume change in response to an environmental condition such as pH. The first compartment includes a screen or membrane for confining the polymer gel network while allowing communication with fluid in an environment. The second compartment contains a biologically active compound or drug which is delivered to the environment through an orifice in the second compartment. Upon the occurrence of the triggering environmental condition, the polymer gel network undergoes a volume change which moves the moveable partition expelling the drug through the orifice. Drug delivery is initiated and continues only when the appropriate environmental condition or trigger is met.

Abstract: Methods and compositions for encapsulated polymeric gels swollen with nonaqueous reactive materials are provided. The methods include gel synthesis, swelling of a gel precursor with a first nonaqueous reactive material, and encapsulation of the swollen gel with a second nonaqueous reactive material. Gels precursors may be synthesized from crosslinking polymers, or alternatively, may be formed by crosslinking and polymerizing a monomer starting material. An accelerator may be utilized to facilitate swelling of the gel precursor with the first nonaqueous reactive material. Foams and composites may also be swollen with the first nonaqueous reactive material. The swollen gel is then contacted with a second nonaqueous reactive material such that an encapsulation layer is formed thereby. The encapsulated gels may be stored for subsequent use.

Abstract: Disclosed are cyanoacrylte compositions comprising a compatible antimicrobial agent and, in particular, a compatible iodine coning antimicrobial agent. These compositions provide for in situ formation of an antimicrobial polymeric cyanoacryate film on mammalian skin.

Abstract: System for delivery of a biologically active substance into an environment. The container is comprised of a single member or two mated members and defines first and second compartments. The container includes pores in at least a portion of the container defining the first compartment. The first compartment contains a polymer gel network which undergoes a volume expansion in response to an environmental condition which varies in the biological environment. The second compartment contains an effective amount of a biologically active compound and may include at least one passageway communicating with the biological environment. Drug delivery is initiated and continues only when the appropriate environmental condition or trigger is met, whereupon volume expansion of the polymer gel network causes the biologically active compound to be discharged into the biological environment.

Abstract: Disclosed are methods for draping a surgical incision site prior to surgery. Specifically, the methods of this invention involve the in situ formation of a biocompatible polymeric drape over the skin surface at the surgical incision site. An incision is then made through this surface and the surgery is then conducted through the incision.