Patents Assigned to Medlogics Device Corporation
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Patent number: 7776379Abstract: Disclosed herein are methods to create medical devices and medical devices including bioactive composite structures. The methods include using template-assisted electro- or electroless deposition or codeposition methods for providing implantable medical devices coated with bioactive composite structures and also include layering deposited or codeposited metal layers with layers of bioactive materials. In one use, the implantable medical devices of the present invention include stents with bioactive composite structure coatings.Type: GrantFiled: August 12, 2005Date of Patent: August 17, 2010Assignee: Medlogics Device CorporationInventors: Michael E. Gertner, Nazila Dadvand, Richard L. Klein, Nathan Christopher Maier
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Publication number: 20090118810Abstract: A stent is provided with modified ends (782, 786) and enhanced drug delivery. The stent assembly also provides for enhanced overlapping between adjacent stents.Type: ApplicationFiled: April 25, 2008Publication date: May 7, 2009Applicant: Medlogics Device CorporationInventors: Richard Klein, James C. Peacock, III
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Publication number: 20080039920Abstract: The present invention relates to devices, systems and methods to maintain self-expanding stents in a compressed form during delivery to and positioning at a treatment site. The devices, systems and methods of the present invention can provide for more accurate stent positioning and can improve the deliverability of self-expanding stents. Designs of the devices, systems and methods of the present invention include slotted designs, tethered designs and encapsulating flexible sheath designs.Type: ApplicationFiled: August 8, 2006Publication date: February 14, 2008Applicant: MEDLOGICS DEVICE CORPORATIONInventors: James C. Peacock, Michael J. Lee
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Publication number: 20080039924Abstract: The present invention relates to devices, systems and methods to maintain self-expanding stents in a compressed form during delivery to and positioning at a treatment site. The devices, systems and methods of the present invention can provide for more accurate stent positioning and can improve the deliverability of self-expanding stents. Designs of the devices, systems and methods of the present invention include slotted designs, tethered designs and encapsulating flexible sheath designs.Type: ApplicationFiled: August 8, 2006Publication date: February 14, 2008Applicant: MEDLOGICS DEVICE CORPORATIONInventors: James C. Peacock, Michael J. Lee
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Publication number: 20080039928Abstract: The present invention relates to devices, systems and methods to maintain self-expanding stents in a compressed form during delivery to and positioning at a treatment site. The devices, systems and methods of the present invention can provide for more accurate stent positioning and can improve the deliverability of self-expanding stents. Designs of the devices, systems and methods of the present invention include slotted designs, tethered designs and encapsulating flexible sheath designs.Type: ApplicationFiled: August 8, 2006Publication date: February 14, 2008Applicant: MEDLOGICS DEVICE CORPORATIONInventors: James C. Peacock, Michael J. Lee
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Publication number: 20070288084Abstract: Disclosed herein are stents with degradable part and/or sections of the stent. The degradable portions of the disclosed stents can provide increased surface area for a period of time for bioactive material deposition or enhanced radiopacity at various locations along the length of the stent. The stents of the present invention also can stent portions of a vessel that are damaged by stent implantation but do not necessarily require long term stenting by providing degradable end sections on the stents of the present invention.Type: ApplicationFiled: June 9, 2006Publication date: December 13, 2007Applicant: MEDLOGICS DEVICE CORPORATIONInventors: Michael J. Lee, Richard L. Klein
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Publication number: 20070181433Abstract: A metallic composite coating, and methods for forming same, for an implantable medical device is disclosed. The composite coating comprises at least one metal or metallic tie layer formed on the surface of the device, followed by an electroless electrochemical cladding of one or more additional layers over the tie layer. One or more therapeutic or biologically active agents are co-deposited with at least one of the electroless electrochemical claddings.Type: ApplicationFiled: April 13, 2007Publication date: August 9, 2007Applicant: MEDLOGICS DEVICE CORPORATIONInventors: Matthew Birdsall, Richard Klein, Nathan Maier
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Patent number: 7208172Abstract: A metallic composite coating, and methods for forming same, for an implantable medical device is disclosed. The composite coating comprises at least one metal or metallic tie layer formed on the surface of the device, followed by an electroless electrochemical cladding of one or more additional layers over the tie layer. One or more therapeutic or biologically active agents are co-deposited with at least one of the electroless electrochemical claddings.Type: GrantFiled: November 3, 2003Date of Patent: April 24, 2007Assignee: Medlogics Device CorporationInventors: Matthew J. Birdsall, Richard L. Klein, Nathan Maier
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Publication number: 20070073390Abstract: Disclosed herein are methods to create medical devices and medical devices including bioactive composite structures with enhanced adhesion characteristics. The bioactive composite structures are prepared using anchors that are electrochemically codeposited into a metallic layer that is formed on the surface of implantable medical device followed by the adhesion of a bioactive material-containing coating to the substrate and anchors.Type: ApplicationFiled: September 23, 2005Publication date: March 29, 2007Applicant: Medlogics Device CorporationInventor: Michael Lee
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Publication number: 20070071789Abstract: Implantable medical devices employing a sol-gel composition coatings that functions as a bioactive material reservoir, and the use of sol-gel composition coatings for improved adhesion of organic and inorganic substrates are disclosed.Type: ApplicationFiled: August 8, 2006Publication date: March 29, 2007Applicant: MEDLOGICS DEVICE CORPORATIONInventors: Dimitrios Pantelidis, John Bravman, Jonathan Rothbard, Richard Klein
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Publication number: 20070050011Abstract: Disclosed herein are various open/closed stent designs and methods for creating the same that can be individually adopted depending on particular treatment objectives. Specifically, the stents of the present invention are manufactured to include different open/closed configurations along their length by varying the number of crossovers, connectors or weld points between sections of the stent. Open portions contain less crossovers, connectors or weld points and are more flexible than closed portions which contain more crossovers, connectors or weld points.Type: ApplicationFiled: August 26, 2005Publication date: March 1, 2007Applicant: Medlogics Device CorporationInventors: Richard Klein, James Peacock, Michael Lee
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Publication number: 20070043418Abstract: A stent and stent deployment system and related methods are disclosed wherein the stent has at least one end segment comprised of a self-expanding material attached to a body portion comprised of a biocompatible material. The stent deployment system comprises a balloon catheter having a stent disposed over the balloon. In one embodiment a stent's end segments extend beyond the proximal and distal ends of the balloon such that they are able to stent a portion of a vessel not expanded or damaged by balloon expansion. This stenting beyond area expanded or damaged by balloon expansion provides for a less abrupt transition between stented and unstented portions of a vessel.Type: ApplicationFiled: August 19, 2005Publication date: February 22, 2007Applicant: Medlogics Device CorporationInventors: Michael Lee, Richard Klein
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Publication number: 20070043427Abstract: Disclosed herein are stents manufactured to include increased surface area for bioactive material deposition or enhanced radiopacity at various locations along the length of the stent. The stents of the present invention also can also be manufactured to create a less abrupt transition between stented and unstented portions of a vessel. A less abrupt transition is created by providing increased surface area for bioactive material deposition at the ends of the stent and/or providing end sections (and sections adjacent thereto) of the stents that are more flexible than more centrally located sections of the stent.Type: ApplicationFiled: August 19, 2005Publication date: February 22, 2007Applicant: Medlogics Device CorporationInventor: Michael Lee
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Publication number: 20070037739Abstract: At least one bioactive agent is locally delivered to a location where a stent is implanted within a lumen in a patient's body. The bioactive agent includes a: DNA minor groove binder (such as CC-1065 or Duocarmycin); apocynin; RGD peptide (such as RGDfV); stilbene compound (such as resveratrol); camptothecin; des-aspartate angiotensin I; or ADF; or an analog or derivative thereof; or a combination or blend thereof with at least one other bioactive agent. The bioactive agent is generally locally delivered, such as by elution from the stent. The compounds and methods are of particular benefit for treating or preventing atherosclerosis, stenosis, restenosis, smooth muscle cell proliferation, occlusive disease, or other abnormal lumenal cellular proliferation condition.Type: ApplicationFiled: February 3, 2004Publication date: February 15, 2007Applicant: Medlogics Device CorporationInventors: Yuqiang Wang, James Larrick, Susan Wright
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Publication number: 20060121180Abstract: One embodiment of the invention is directed to a method comprising providing an electrochemical solution comprising metal ions and a bioactive material such as bioactive molecules, and then contacting the electrochemical solution and a substrate. A bioactive composite structure is formed on the substrate using an electrochemical process, where the bioactive composite structure includes a metal matrix and the bioactive material within the metal matrix.Type: ApplicationFiled: January 20, 2006Publication date: June 8, 2006Applicant: Medlogics Device CorporationInventors: Michael Gertner, Mordechay Schlesinger
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Publication number: 20060115512Abstract: Disclosed herein are methods to create medical devices and implantable medical devices with an electrochemically engineered porous surface that contains one or more bioactive materials to form bioactive composite structures. The bioactive composite structures are prepared using electrochemical codeposition methods to create metallic layers with pores that can be loaded with bioactive materials. In one use, the implantable medical devices of the present invention include stents with bioactive composite structure coatings.Type: ApplicationFiled: September 9, 2005Publication date: June 1, 2006Applicant: Medlogics Device CorporationInventors: James Peacock, Richard Klein, Michael Lee
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Publication number: 20060085062Abstract: A stent is provided in combination with a growth factor, specifically pleiotrophin or an analog or derivative thereof, which promotes endothelialization of the stent and re-endothelialization of the stented region of an injured site in a body lumen. In particular applications, the stent is an endolumenal stent and the growth factor promotes healing via endothelialization and substantially prevents restenosis. The growth factor is delivered from the stent formulated as a protein or peptide, or as a gene transfer vector. Methods for the treatment of vascular injury using pleiotrophin are also disclosed.Type: ApplicationFiled: September 8, 2005Publication date: April 20, 2006Applicant: Medlogics Device CorporationInventors: Randall Lee, Kenneth Colley, James Peacock
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Publication number: 20060062820Abstract: Disclosed herein are methods to create medical devices and medical devices including bioactive composite structures. The methods include using template-assisted electro- or electroless deposition or codeposition methods for providing implantable medical devices coated with bioactive composite structures and also include layering deposited or codeposited metal layers with layers of bioactive materials. In one use, the implantable medical devices of the present invention include stents with bioactive composite structure coatings.Type: ApplicationFiled: August 12, 2005Publication date: March 23, 2006Applicant: Medlogics Device CorporationInventors: Michael Gertner, Nazila Dadvand, Richard Klein, Nathan Maier
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Publication number: 20060051397Abstract: Disclosed herein are methods to create medical devices and medical devices including bioactive composite structures. The methods include using electroless and electrophoretic deposition and codeposition methods for providing implantable medical devices coated with bioactive composite structures. In one use, the implantable medical devices of the present invention include stents with bioactive composite structures.Type: ApplicationFiled: September 6, 2005Publication date: March 9, 2006Applicant: Medlogics Device CorporationInventors: Nathan Maier, Richard Klein
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Publication number: 20050186250Abstract: One embodiment of the invention is directed to a method comprising providing an electrochemical solution comprising metal ions and a bioactive material such as bioactive molecules, and then contacting the electrochemical solution and a substrate. A bioactive composite structure is formed on the substrate using an electrochemical process, where the bioactive composite structure includes a metal matrix and the bioactive material within the metal matrix.Type: ApplicationFiled: March 24, 2005Publication date: August 25, 2005Applicant: Medlogics Device CorporationInventors: Michael Gertner, Mordechay Schlesinger