Patents Assigned to MedRelief Inc.
  • Patent number: 10544388
    Abstract: Compositions and methods are provided for modulating the growth, development and repair of bone, cartilage or other connective tissue. Devices and stimulus waveforms are provided to differentially modulate the behavior of osteoblasts, chondrocytes and other connective tissue cells to promote proliferation, differentiation, matrix formation or mineralization for in vitro or in vivo applications. Continuous-mode and pulse-burst-mode stimulation of cells with charge-balanced signals may be used. Bone, cartilage and other connective tissue growth is stimulated in part by nitric oxide release through electrical stimulation and may be modulated through co-administration of NO donors and NO synthase inhibitors. Bone, cartilage and other connective tissue growth is stimulated in part by release of BMP-2 and BMP-7 in response to electrical stimulation to promote differentiation of cells.
    Type: Grant
    Filed: November 15, 2017
    Date of Patent: January 28, 2020
    Assignee: MEDRELIEF INC.
    Inventors: James W. Kronberg, Timothy Ganey, Stephen L. Gordon
  • Patent number: 9845452
    Abstract: Compositions and methods are provided for modulating the growth, development and repair of bone, cartilage or other connective tissue. Devices and stimulus waveforms are provided to differentially modulate the behavior of osteoblasts, chondrocytes and other connective tissue cells to promote proliferation, differentiation, matrix formation or mineralization for in vitro or in vivo applications. Continuous-mode and pulse-burst-mode stimulation of cells with charge-balanced signals may be used. Bone, cartilage and other connective tissue growth is stimulated in part by nitric oxide release through electrical stimulation and may be modulated through co-administration of NO donors and NO synthase inhibitors. Bone, cartilage and other connective tissue growth is stimulated in part by release of BMP-2 and BMP-7 in response to electrical stimulation to promote differentiation of cells.
    Type: Grant
    Filed: March 20, 2017
    Date of Patent: December 19, 2017
    Assignee: MEDRELIEF INC.
    Inventors: James W. Kronberg, Timothy Ganey, Stephen L. Gordon
  • Patent number: 9630001
    Abstract: Compositions and methods are provided for modulating the growth, development and repair of bone, cartilage or other connective tissue. Devices and stimulus waveforms are provided to differentially modulate the behavior of osteoblasts, chondrocytes and other connective tissue cells to promote proliferation, differentiation, matrix formation or mineralization for in vitro or in vivo applications. Continuous-mode and pulse-burst-mode stimulation of cells with charge-balanced signals may be used. Bone, cartilage and other connective tissue growth is stimulated in part by nitric oxide release through electrical stimulation and may be modulated through co-administration of NO donors and NO synthase inhibitors. Bone, cartilage and other connective tissue growth is stimulated in part by release of BMP-2 and BMP-7 in response to electrical stimulation to promote differentiation of cells.
    Type: Grant
    Filed: June 9, 2014
    Date of Patent: April 25, 2017
    Assignee: MEDRELIEF INC.
    Inventors: James W. Kronberg, Timothy Ganey, Stephen L. Gordon
  • Patent number: 9421357
    Abstract: Systems, apparatuses, and methods for providing non-transcranial electrical stimuli to a biological subject may employ a support structure, at least one waveform generator, and at least a first electrode and a second electrode. The system can be sized and dimensioned to be worn on a head of the biological subject and operable to deliver non-transcranial electrical stimuli to at least one of the temporomandibular joints of the biological subject.
    Type: Grant
    Filed: January 22, 2015
    Date of Patent: August 23, 2016
    Assignee: MEDRELIEF INC.
    Inventor: Christian Walker
  • Patent number: 8972024
    Abstract: Systems, apparatuses, and methods for providing non-transcranial electrical stimuli to a biological subject may employ a support structure, at least one waveform generator, and at least a first electrode and a second electrode. The system can be sized and dimensioned to be worn on a head of the biological subject and operable to deliver non-transcranial electrical stimuli to at least one of the temporomandibular joints of the biological subject.
    Type: Grant
    Filed: June 19, 2009
    Date of Patent: March 3, 2015
    Assignee: MedRelief Inc.
    Inventor: Christian Walker
  • Patent number: 8785196
    Abstract: Compositions and methods are provided for modulating the growth, development and repair of bone, cartilage or other connective tissue. Devices and stimulus waveforms are provided to differentially modulate the behavior of osteoblasts, chondrocytes and other connective tissue cells to promote proliferation, differentiation, matrix formation or mineralization for in vitro or in vivo applications. Continuous-mode and pulse-burst-mode stimulation of cells with charge-balanced signals may be used. Bone, cartilage and other connective tissue growth is stimulated in part by nitric oxide release through electrical stimulation and may be modulated through co-administration of NO donors and NO synthase inhibitors. Bone, cartilage and other connective tissue growth is stimulated in part by release of BMP-2 and BMP-7 in response to electrical stimulation to promote differentiation of cells.
    Type: Grant
    Filed: October 14, 2010
    Date of Patent: July 22, 2014
    Assignee: MedRelief Inc.
    Inventors: James W. Kronberg, Timothy Ganey, Stephen L. Gordon
  • Patent number: 8159312
    Abstract: A method and class of circuit configurations for coupling low-frequency signals from one stage of an electronic apparatus to another stage, from the outside world to such a stage, or from such a stage to the outside world, through the use of a plurality of symmetrical double-layer capacitors combined with other electronic components are disclosed. The capacitors are used for signal transmission while blocking direct current, rather than for energy storage. Use of double-layer capacitors in place of more conventional capacitors permits the transmission of a much wider range of signals with far less distortion. The technology is particularly well-adapted to use in medical devices, including bioelectronic stimulators, where redundant devices are required for safety in case of single component failure while unacceptable levels of distortion may occur when conventional components are used.
    Type: Grant
    Filed: June 27, 2007
    Date of Patent: April 17, 2012
    Assignee: MedRelief Inc.
    Inventor: James W. Kronberg
  • Publication number: 20110217775
    Abstract: Compositions and methods are provided for modulating the growth, development and repair of bone, cartilage or other connective tissue. Devices and stimulus waveforms are provided to differentially modulate the behavior of osteoblasts, chondrocytes and other connective tissue cells to promote proliferation, differentiation, matrix formation or mineralization for in vitro or in vivo applications. Continuous-mode and pulse-burst-mode stimulation of cells with charge-balanced signals may be used. Bone, cartilage and other connective tissue growth is stimulated in part by nitric oxide release through electrical stimulation and may be modulated through co-administration of NO donors and NO synthase inhibitors. Bone, cartilage and other connective tissue growth is stimulated in part by release of BMP-2 and BMP-7 in response to electrical stimulation to promote differentiation of cells.
    Type: Application
    Filed: October 14, 2010
    Publication date: September 8, 2011
    Applicant: MEDRELIEF INC.
    Inventors: James W. Kronberg, Timothy Ganey, Stephen L. Gordon
  • Publication number: 20110160811
    Abstract: Systems, apparatuses, and methods for providing non-transcranial electrical stimuli to a biological subject may employ a support structure, at least one waveform generator, and at least a first electrode and a second electrode. The system can be sized and dimensioned to be worn on a head of the biological subject and operable to deliver non-transcranial electrical stimuli to at least one of the temporomandibular joints of the biological subject.
    Type: Application
    Filed: June 19, 2009
    Publication date: June 30, 2011
    Applicant: MEDRELIEF INC.
    Inventor: Christian Walker
  • Patent number: 7840272
    Abstract: Compositions and methods are provided for modulating the growth, development and repair of bone, cartilage or other connective tissue. Devices and stimulus waveforms are provided to differentially modulate the behavior of osteoblasts, chondrocytes and other connective tissue cells to promote proliferation, differentiation, matrix formation or mineralization for in vitro or in vivo applications. Continuous-mode and pulse-burst-mode stimulation of cells with charge-balanced signals may be used. Bone, cartilage and other connective tissue growth is stimulated in part by nitric oxide release through electrical stimulation and may be modulated through co-administration of NO donors and NO synthase inhibitors. Bone, cartilage and other connective tissue growth is stimulated in part by release of BMP-2 and BMP-7 in response to electrical stimulation to promote differentiation of cells.
    Type: Grant
    Filed: May 22, 2006
    Date of Patent: November 23, 2010
    Assignee: MedRelief Inc.
    Inventors: James W. Kronberg, Timothy Ganey, Stephen L. Gordon
  • Patent number: RE43374
    Abstract: An apparatus for generating an electrical signal for use in biomedical applications, including two timing blocks for generating timing intervals T1-T7, an interconnection block for combining these intervals into an output signal having predetermined relationships among the intervals, an output block for transmitting the output signal to a load, and, optionally, a filter for removing unwanted frequency components from the output signal and an adjustment block for selecting from among a plurality of output signals with predetermined characteristics. The output is a repeating succession of a burst of rectangular waves, an equalizing pulse (if needed) to cancel net DC, and a rest period of no signal.
    Type: Grant
    Filed: March 18, 2005
    Date of Patent: May 8, 2012
    Assignee: MedRelief Inc.
    Inventor: James W. Kronberg