Patents Assigned to MedRelief Inc.
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Patent number: 11618874Abstract: Compositions and methods are provided for modulating the growth, development and repair of bone, cartilage or other connective tissue. Devices and stimulus waveforms are provided to differentially modulate the behavior of osteoblasts, chondrocytes and other connective tissue cells to promote proliferation, differentiation, matrix formation or mineralization for in vitro or in vivo applications. Continuous-mode and pulse-burst-mode stimulation of cells with charge-balanced signals may be used. Bone, cartilage and other connective tissue growth is stimulated in part by nitric oxide release through electrical stimulation and may be modulated through co-administration of NO donors and NO synthase inhibitors. Bone, cartilage and other connective tissue growth is stimulated in part by release of BMP-2 and BMP-7 in response to electrical stimulation to promote differentiation of cells.Type: GrantFiled: December 19, 2019Date of Patent: April 4, 2023Assignee: MEDRELIEF INC.Inventors: James W. Kronberg, Timothy Ganey, Stephen L. Gordon
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Patent number: 10544388Abstract: Compositions and methods are provided for modulating the growth, development and repair of bone, cartilage or other connective tissue. Devices and stimulus waveforms are provided to differentially modulate the behavior of osteoblasts, chondrocytes and other connective tissue cells to promote proliferation, differentiation, matrix formation or mineralization for in vitro or in vivo applications. Continuous-mode and pulse-burst-mode stimulation of cells with charge-balanced signals may be used. Bone, cartilage and other connective tissue growth is stimulated in part by nitric oxide release through electrical stimulation and may be modulated through co-administration of NO donors and NO synthase inhibitors. Bone, cartilage and other connective tissue growth is stimulated in part by release of BMP-2 and BMP-7 in response to electrical stimulation to promote differentiation of cells.Type: GrantFiled: November 15, 2017Date of Patent: January 28, 2020Assignee: MEDRELIEF INC.Inventors: James W. Kronberg, Timothy Ganey, Stephen L. Gordon
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Patent number: 9845452Abstract: Compositions and methods are provided for modulating the growth, development and repair of bone, cartilage or other connective tissue. Devices and stimulus waveforms are provided to differentially modulate the behavior of osteoblasts, chondrocytes and other connective tissue cells to promote proliferation, differentiation, matrix formation or mineralization for in vitro or in vivo applications. Continuous-mode and pulse-burst-mode stimulation of cells with charge-balanced signals may be used. Bone, cartilage and other connective tissue growth is stimulated in part by nitric oxide release through electrical stimulation and may be modulated through co-administration of NO donors and NO synthase inhibitors. Bone, cartilage and other connective tissue growth is stimulated in part by release of BMP-2 and BMP-7 in response to electrical stimulation to promote differentiation of cells.Type: GrantFiled: March 20, 2017Date of Patent: December 19, 2017Assignee: MEDRELIEF INC.Inventors: James W. Kronberg, Timothy Ganey, Stephen L. Gordon
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Patent number: 9630001Abstract: Compositions and methods are provided for modulating the growth, development and repair of bone, cartilage or other connective tissue. Devices and stimulus waveforms are provided to differentially modulate the behavior of osteoblasts, chondrocytes and other connective tissue cells to promote proliferation, differentiation, matrix formation or mineralization for in vitro or in vivo applications. Continuous-mode and pulse-burst-mode stimulation of cells with charge-balanced signals may be used. Bone, cartilage and other connective tissue growth is stimulated in part by nitric oxide release through electrical stimulation and may be modulated through co-administration of NO donors and NO synthase inhibitors. Bone, cartilage and other connective tissue growth is stimulated in part by release of BMP-2 and BMP-7 in response to electrical stimulation to promote differentiation of cells.Type: GrantFiled: June 9, 2014Date of Patent: April 25, 2017Assignee: MEDRELIEF INC.Inventors: James W. Kronberg, Timothy Ganey, Stephen L. Gordon
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Patent number: 9421357Abstract: Systems, apparatuses, and methods for providing non-transcranial electrical stimuli to a biological subject may employ a support structure, at least one waveform generator, and at least a first electrode and a second electrode. The system can be sized and dimensioned to be worn on a head of the biological subject and operable to deliver non-transcranial electrical stimuli to at least one of the temporomandibular joints of the biological subject.Type: GrantFiled: January 22, 2015Date of Patent: August 23, 2016Assignee: MEDRELIEF INC.Inventor: Christian Walker
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Patent number: 8972024Abstract: Systems, apparatuses, and methods for providing non-transcranial electrical stimuli to a biological subject may employ a support structure, at least one waveform generator, and at least a first electrode and a second electrode. The system can be sized and dimensioned to be worn on a head of the biological subject and operable to deliver non-transcranial electrical stimuli to at least one of the temporomandibular joints of the biological subject.Type: GrantFiled: June 19, 2009Date of Patent: March 3, 2015Assignee: MedRelief Inc.Inventor: Christian Walker
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Patent number: 8785196Abstract: Compositions and methods are provided for modulating the growth, development and repair of bone, cartilage or other connective tissue. Devices and stimulus waveforms are provided to differentially modulate the behavior of osteoblasts, chondrocytes and other connective tissue cells to promote proliferation, differentiation, matrix formation or mineralization for in vitro or in vivo applications. Continuous-mode and pulse-burst-mode stimulation of cells with charge-balanced signals may be used. Bone, cartilage and other connective tissue growth is stimulated in part by nitric oxide release through electrical stimulation and may be modulated through co-administration of NO donors and NO synthase inhibitors. Bone, cartilage and other connective tissue growth is stimulated in part by release of BMP-2 and BMP-7 in response to electrical stimulation to promote differentiation of cells.Type: GrantFiled: October 14, 2010Date of Patent: July 22, 2014Assignee: MedRelief Inc.Inventors: James W. Kronberg, Timothy Ganey, Stephen L. Gordon
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Patent number: 8159312Abstract: A method and class of circuit configurations for coupling low-frequency signals from one stage of an electronic apparatus to another stage, from the outside world to such a stage, or from such a stage to the outside world, through the use of a plurality of symmetrical double-layer capacitors combined with other electronic components are disclosed. The capacitors are used for signal transmission while blocking direct current, rather than for energy storage. Use of double-layer capacitors in place of more conventional capacitors permits the transmission of a much wider range of signals with far less distortion. The technology is particularly well-adapted to use in medical devices, including bioelectronic stimulators, where redundant devices are required for safety in case of single component failure while unacceptable levels of distortion may occur when conventional components are used.Type: GrantFiled: June 27, 2007Date of Patent: April 17, 2012Assignee: MedRelief Inc.Inventor: James W. Kronberg
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Publication number: 20110217775Abstract: Compositions and methods are provided for modulating the growth, development and repair of bone, cartilage or other connective tissue. Devices and stimulus waveforms are provided to differentially modulate the behavior of osteoblasts, chondrocytes and other connective tissue cells to promote proliferation, differentiation, matrix formation or mineralization for in vitro or in vivo applications. Continuous-mode and pulse-burst-mode stimulation of cells with charge-balanced signals may be used. Bone, cartilage and other connective tissue growth is stimulated in part by nitric oxide release through electrical stimulation and may be modulated through co-administration of NO donors and NO synthase inhibitors. Bone, cartilage and other connective tissue growth is stimulated in part by release of BMP-2 and BMP-7 in response to electrical stimulation to promote differentiation of cells.Type: ApplicationFiled: October 14, 2010Publication date: September 8, 2011Applicant: MEDRELIEF INC.Inventors: James W. Kronberg, Timothy Ganey, Stephen L. Gordon
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Publication number: 20110160811Abstract: Systems, apparatuses, and methods for providing non-transcranial electrical stimuli to a biological subject may employ a support structure, at least one waveform generator, and at least a first electrode and a second electrode. The system can be sized and dimensioned to be worn on a head of the biological subject and operable to deliver non-transcranial electrical stimuli to at least one of the temporomandibular joints of the biological subject.Type: ApplicationFiled: June 19, 2009Publication date: June 30, 2011Applicant: MEDRELIEF INC.Inventor: Christian Walker
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Patent number: 7840272Abstract: Compositions and methods are provided for modulating the growth, development and repair of bone, cartilage or other connective tissue. Devices and stimulus waveforms are provided to differentially modulate the behavior of osteoblasts, chondrocytes and other connective tissue cells to promote proliferation, differentiation, matrix formation or mineralization for in vitro or in vivo applications. Continuous-mode and pulse-burst-mode stimulation of cells with charge-balanced signals may be used. Bone, cartilage and other connective tissue growth is stimulated in part by nitric oxide release through electrical stimulation and may be modulated through co-administration of NO donors and NO synthase inhibitors. Bone, cartilage and other connective tissue growth is stimulated in part by release of BMP-2 and BMP-7 in response to electrical stimulation to promote differentiation of cells.Type: GrantFiled: May 22, 2006Date of Patent: November 23, 2010Assignee: MedRelief Inc.Inventors: James W. Kronberg, Timothy Ganey, Stephen L. Gordon
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Patent number: RE43374Abstract: An apparatus for generating an electrical signal for use in biomedical applications, including two timing blocks for generating timing intervals T1-T7, an interconnection block for combining these intervals into an output signal having predetermined relationships among the intervals, an output block for transmitting the output signal to a load, and, optionally, a filter for removing unwanted frequency components from the output signal and an adjustment block for selecting from among a plurality of output signals with predetermined characteristics. The output is a repeating succession of a burst of rectangular waves, an equalizing pulse (if needed) to cancel net DC, and a rest period of no signal.Type: GrantFiled: March 18, 2005Date of Patent: May 8, 2012Assignee: MedRelief Inc.Inventor: James W. Kronberg