Abstract: A disposable injection syringe for allowing a comfortable injection at a low injury risk of the user. The syringe includes an injection needle, a tubular cylinder having a free opening at a first end, an end part with a through hole for slidably accommodating the injection needle at an opening of a second end of the tubular cylinder opposite the free opening, a piston reciprocally accommodated in the cylinder, a piston rod attached to the piston and extending into the cylinder through the free opening of the cylinder, a coupling for interlocking the piston and the injection needle at least in the reverse direction of the injection piston stroke. The coupling has two coupling parts, one of which is attached to the piston and the other of which is attached to the injection needle. The coupling parts are spaced from each other during at least part of the injection stroke and interlock during withdrawal.