Abstract: A medical imaging system includes an imaging device configured to scan a region of interest to acquire at least one of a first image including a first plurality of pixels and a second image including a second plurality of pixels, a processing unit configured to receive the first and second images, calculate respective first neutrosophic similarity scores for each of the first plurality of pixels of the first image, calculate respective second neutrosophic similarity scores for each of the second plurality of pixels of the second image, perform a template matching algorithm based on differences between the respective first and second neutrosophic similarity scores for each of the first and second plurality, respectively, to determine one or more registration parameters, and register the first and second images using the one or more registration parameters, and a display output configured to allow the registered first and second images to be displayed.