Abstract: A stapling device (100) for attaching a clip (205) to tissue is disclosed comprising a sheath (101) having a distal end (102) for delivery of said clip, a pusher unit (103, 103?) being movable inside said sheath along a longitudinal direction (104) of said sheath, said distal end comprising a clip guide (105, 105?) in which said clip is movable in said longitudinal direction, wherein said clip guide has a closed (G) configuration in which said clip guide is adapted to apply a restraining force on said clip so that said clip assumes a delivery shape (C), and an open (G?) configuration in which said clip assumes a relaxed shape (C?), wherein said pusher unit is movable from a proximal position (P) in which said clip guide is in said closed configuration, to a distal position (P?) in which said pusher unit engages said clip guide and the clip guide is in said open configuration.