Patents Assigned to Medtronic Ardian Luxembourg S.a.r.l.
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Patent number: 8958871Abstract: Methods and apparatus are provided for pulsed electric field neuromodulation via an intra-to-extravascular approach, e.g., to effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, changes in cytokine upregulation and other conditions in target neural fibers. In some embodiments, the ITEV PEF system comprises an intravascular catheter having one or more electrodes configured for intra-to-extravascular placement across a wall of patient's vessel into proximity with target neural fibers. With the electrode(s) passing from an intravascular position to an extravascular position prior to delivery of the PEF, a magnitude of applied voltage or energy delivered via the electrode(s) and necessary to achieve desired neuromodulation may be reduced relative to an intravascular PEF system having one or more electrodes positioned solely intravascularly.Type: GrantFiled: January 14, 2011Date of Patent: February 17, 2015Assignee: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Denise Demarais, Benjamin J. Clark, Nicolas Zadno, Erik Thai, Hanson Gifford, III
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Patent number: 8951296Abstract: Devices and methods for therapeutic photodynamic modulation of neural function in a human. One embodiment of a method in accordance with the technology includes administering a photosensitizer to a human, wherein the photosensitizer preferentially accumulates at nerves proximate a blood vessel compared to non-neural tissue of the blood vessel. The method can further include irradiating the photosensitizer using a radiation emitter positioned within the human, wherein the radiation has a wavelength that causes the photosensitizer to react and alter at least a portion of the nerves thereby providing a therapeutic reduction in sympathetic neural activity. Several embodiments of the technology are useful for disrupting renal nerves, such as renal denervation, for treating hypertension, diabetes, congestive heart failure, and other indications.Type: GrantFiled: March 14, 2013Date of Patent: February 10, 2015Assignee: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Robert J. Melder, Ayala Hezi-Yamit, Christopher W. Storment, Carol M. Sullivan
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Patent number: 8945107Abstract: Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.Type: GrantFiled: October 23, 2011Date of Patent: February 3, 2015Assignee: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Naomi Buckley, Benjamin J. Clark, Michael Cummins, Danny Donovan, Luke Hughes, Brian Kelly, Gary Kelly, Grace Kelly, John Kelly, Seamus Ledwith, Gwenda McMullin, Karun D. Naga, Stephen Nash, Francesco Piccagli, Eric Ryba, Fiachra Sweeney, Vincenzo Tilotta, Roman Turovskiy, Lana Woolley, Denise Zarins, Mark Gelfand, Mark S. Leung, Barry Mullins
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Patent number: 8948865Abstract: Methods and apparatus are provided for treatment of heart arrhythmia via renal neuromodulation. Such neuromodulation may effectuate irreversible electroporation or electrofusion, ablation, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, such neuromodulation is achieved through application of an electric field. In some embodiments, such neuromodulation is achieved through application of neuromodulatory agents, of thermal energy and/or of high intensity focused ultrasound. In some embodiments, such neuromodulation is performed in a bilateral fashion.Type: GrantFiled: November 15, 2013Date of Patent: February 3, 2015Assignee: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Denise Zarins, Hanson Gifford, III
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Patent number: 8934978Abstract: Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation.Type: GrantFiled: April 22, 2014Date of Patent: January 13, 2015Assignee: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Mark E. Deem, Hanson Gifford, III, Denise Zarins, Douglas Sutton, Erik Thai, Mark Gelfand, Howard R. Levin
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Publication number: 20150005676Abstract: Methods and apparatus are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues.Type: ApplicationFiled: June 6, 2014Publication date: January 1, 2015Applicant: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Denise Zarins, Nicolas Zadno, Benjamin J. Clark, Erik Thai, Howard R. Levin, Mark Gelfand
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Patent number: 8888773Abstract: Catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present technology, for example, is directed to a treatment device having a multi-electrode array configured to be delivered to a renal blood vessel. The array is selectively transformable between a delivery or low-profile state (e.g., a generally straight shape) and a deployed state (e.g., a radially expanded, generally spiral/helical shape). The multi-electrode array is sized and shaped so that the electrodes or energy delivery elements contact an interior wall of the renal blood vessel when the array is in the deployed (e.g., spiral/helical) state. The electrodes or energy delivery elements are configured for direct and/or indirect application of thermal and/or electrical energy to heat or otherwise electrically modulate neural fibers that contribute to renal function.Type: GrantFiled: March 11, 2013Date of Patent: November 18, 2014Assignee: Medtronic Ardian Luxembourg S.a.r.l.Inventors: William W. Chang, Justin Goshgarian, Kevin Michael Mauch, Leonila Rivera, Sukyoung Shin, Don H. Tran
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APPARATUS, SYSTEMS, AND METHODS FOR ACHIEVING INTRAVASCULAR, THERMALLY-INDUCED RENAL NEUROMODULATION
Publication number: 20140336631Abstract: Apparatus, systems, and methods for achieving thermally-induced renal neuromodulation by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver a thermal element to a renal artery via an intravascular path. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers.Type: ApplicationFiled: May 22, 2014Publication date: November 13, 2014Applicant: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Andrew Wu, Benjamin J. Clark, Denise Zarins, Erik Thai -
Patent number: 8880186Abstract: A method and apparatus for treatment of heart failure, hypertension and renal failure by stimulating the renal nerve. The goal of therapy is to reduce sympathetic activity of the renal nerve. Therapy is accomplished by at least partially blocking the nerve with drug infusion or electrostimulation. Apparatus can be permanently implanted or catheter based.Type: GrantFiled: April 11, 2013Date of Patent: November 4, 2014Assignee: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Howard R. Levin, Mark Gelfand
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Publication number: 20140324016Abstract: A method and apparatus for treatment of cardiac and renal diseases associated with the elevated sympathetic renal nerve activity by implanting a device to block the renal nerve signals to and from the kidney. The device can be a drug pump or a drug eluding implant for targeted delivery of a nerve-blocking agent to the periarterial space of the renal artery.Type: ApplicationFiled: March 21, 2014Publication date: October 30, 2014Applicant: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Mark Gelfand, Howard R. Levin
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Patent number: 8870863Abstract: Catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a catheter treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver an energy delivery element to a renal artery via an intravascular path. Thermal or electrical renal neuromodulation may be achieved via direct and/or via indirect application of thermal and/or electrical energy to heat or cool, or otherwise electrically modulate, neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers.Type: GrantFiled: May 28, 2010Date of Patent: October 28, 2014Assignee: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Mark S. Leung, Benjamin J. Clark, Kenneth J. Michlitsch, Erik Thai, Andrew Wu, Denise Zarins
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Publication number: 20140316402Abstract: The present disclosure relates to devices, systems and methods for positioning a neuromodulation device at a treatment site and evaluating the effects of therapeutic energy delivery applied to tissue in a patient. Before, during and/or after therapeutic energy delivery, a system can monitor parameters or values relevant to efficacious neuromodulation by emitting and detecting diagnostic energy at the treatment site. Feedback provided to an operator is based on the monitored values and relates to a relative position of the treatment device at the treatment site, as well as assessment of the likelihood that a completed treatment was technically successful.Type: ApplicationFiled: March 14, 2014Publication date: October 23, 2014Applicant: Medtronic Ardian Luxembourg S.a.r.l.Inventor: Jignesh M. Shah
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Publication number: 20140303618Abstract: Multi-directional deflectable catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a catheter treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver a thermal element to a renal artery via an intravascular path. Thermally or electrical renal neuromodulation may be achieved via direct and/or via indirect application of thermal and/or electrical energy to heat or cool, or otherwise electrically modulate, neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers.Type: ApplicationFiled: April 3, 2014Publication date: October 9, 2014Applicant: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Andrew Wu, Benjamin J. Clark, Denise Zarins, Erik Thai, Kenneth J. Michlitsch, Mark S. Leung
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Patent number: 8852163Abstract: Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation.Type: GrantFiled: June 28, 2013Date of Patent: October 7, 2014Assignee: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Mark E. Deem, Hanson Gifford, III, Denise Zarins, Douglas Sutton, Erik Thai, Mark Gelfand, Howard R. Levin
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Patent number: 8845629Abstract: Methods and apparatus are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues.Type: GrantFiled: April 5, 2010Date of Patent: September 30, 2014Assignee: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Denise Demarais, Nicolas Zadno, Benjamin J. Clark, Erik Thai, Howard R. Levin, Mark Gelfand
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Publication number: 20140288545Abstract: Methods and apparatus are provided for bilateral renal neuromodulation, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such neuromodulation is performed in a bilateral fashion. Bilateral renal neuromodulation may provide enhanced therapeutic effect in some patients as compared to renal neuromodulation performed unilaterally, i.e., as compared to renal neuromodulation performed on neural tissue innervating a single kidney.Type: ApplicationFiled: April 23, 2014Publication date: September 25, 2014Applicant: Medtronic Ardian Luxembourg S.a.r.lInventors: Denise Zarins, Hanson Gifford, Mark Deem, Douglas Sutton, Howard R. Levin, Mark Gelfand
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Publication number: 20140276791Abstract: Treatment devices with electrode contact surfaces configured for enhancing uniformity of electrical energy distribution are provided. In one embodiment, a treatment device includes a tubular electrode having a wall, a contact surface defined by the wall, and cut shapes at least partially extending through the wall. The tubular electrode is configured to transmit electrical energy to a treatment site within a body lumen via the contact surface, and the individual cut shapes are configured to draw a portion of the electrical energy toward an interior region of the contact surface. A shaft having a distal end portion operably coupled to the tubular electrode can locate the tubular electrode at the treatment site.Type: ApplicationFiled: March 13, 2014Publication date: September 18, 2014Applicant: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Vincent W. Ku, Joan A. Simon, Andrew E. Wu, Mingfei Chen, Nancy P. Nguyen
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Publication number: 20140276727Abstract: A device and method for retrieving an electrode array. The medical device includes a catheter defining a proximal end, a distal end, and a lumen therethrough. A control wire slidably receivable within the lumen is included, the control wire defining a proximal end and a distal end, the distal end of the control wire defining an enlarged portion. A treatment portion receivable within the lumen is included, the treatment portion including a proximal portion adapted to receive the enlarged portion at the distal end of the control wire.Type: ApplicationFiled: March 14, 2013Publication date: September 18, 2014Applicant: MEDTRONIC ARDIAN LUXEMBOURG S.A.R.L.Inventor: Carlo Guala
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Publication number: 20140276718Abstract: Catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present technology, for example, is directed to a treatment device including a therapeutic assembly having a central axis and a distal portion and a proximal portion axially spaced along the central axis, the therapeutic assembly including a core element extending from the proximal portion to the distal portion and a heating element disposed along at least a portion of a length of the core element. An energy source provides electrical current to the heating element to cause the heating element to increase in temperature.Type: ApplicationFiled: March 11, 2014Publication date: September 18, 2014Applicant: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Roman Turovskiy, Robert J. Beetel, Kevin M. Mauch, Christopher W. Storment
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Patent number: D712833Type: GrantFiled: March 4, 2013Date of Patent: September 9, 2014Assignee: Medtronic Ardian Luxembourg S.a.r.l.Inventors: William R. George, Charles R. Lewis, Jr.