Abstract: Biocompatible coatings for medical devices are disclosed. Specifically, polymer coatings designed to control the release of bioactive agents from medical devices in vivo are disclosed wherein the solubility parameters of polymers and drugs are closely matched to control elute rate profiles. The present application also discloses providing vascular stents with controlled release coatings and related methods for making these coatings.

Abstract: N-substituted 4-aza-caprolactone biodegradable polymers, including derivatives thereof, useful for making implantable medical devices and coatings therefore are provided. The medical devices and coatings of the present invention can also be used for in situ controlled release drug delivery and are useful for treating or preventing medical conditions such as restenosis, aneurisms and vulnerable plaque.

Abstract: An intraluminal stent, an intraluminal stent delivery system, and a method treating a vascular condition. The stent includes a framework including an elongated spiral seam. The framework includes a side edge including an angle formed with respect to an end edge. The system includes a catheter and a stent. The stent includes a framework including an elongated spiral seam. The framework includes a side edge including an angle formed with respect to an end edge. The method includes positioning a stent including at least one spiral seam at a target region of a vessel. The stent is expanded from a compressed configuration to a deployed configuration. At least one therapeutic agent is delivered from the stent along the at least one spiral seam.