Abstract: A method includes detecting whether one or more myocardial infarctions (MI) has occurred using vectorcardiographic (VCG) signals with gradient boosting, the VCG signals including VCG loops, and determining an MI location using the VCG signals and gradient boosting.

Abstract: Laser ablation devices and related systems and methods may have laser outputs with multiple wavelengths. Laser ablation devices may include a laser energy source that can emit two or more laser outputs with different wavelengths. Some laser ablation devices include a processor to control the laser energy source to cause the laser energy source to emit a target wavelength blend with the laser outputs.

Abstract: A method of forming an electrospun prosthetic valve includes utilizing a rotatable and angularly adjustable prosthetic valve mold. The prosthetic valve mold is set to a first angle. The prosthetic valve mold is rotated at a first rotational velocity and a first layer of electrospun fibers is deposited on the prosthetic valve mold. The prosthetic valve mold is stopped and a frame is positioned over the first layer. The prosthetic valve mold is set to a second angle. The prosthetic valve mold is rotated at a second velocity and a second layer of electrospun fibers is deposited on an outer surface of the first layer and an outer surface of the frame.

Abstract: A medical device system includes a cardiac electrical stimulation device and a ventricular assist device (VAD). The cardiac stimulation device and the VAD are capable of communication with each other to confirm detection of cardiac events.

Abstract: Systems and methods are described herein for use in synchronizing electrical activity monitored by a plurality of external electrodes with supplemental cardiac data for use in evaluating a patient's cardiac condition and configuring cardiac therapy. The supplemental cardiac data may include one or more markers indicative of the occurrence of cardiac events and/or data representative of representative of at least one of cardiac electrical signals, cardiac sounds, cardiac pressures, blood flow, and an estimated instantaneous flow waveform provided by a left ventricular assist device.

Abstract: The present disclosure provides a tissue-removing catheter for removing tissue in a body lumen that includes an elongate body, a handle, tissue-removing element, liner assembly, and coupling assembly. The elongate body is sized and shaped to be received in the body lumen. The tissue-removing element is mounted on a distal end portion of the elongate body and removes tissue as rotated by the elongate body. The liner assembly defines a guidewire lumen. The coupling assembly is coupled to the liner assembly with a first orientation and a second orientation relative to the coupling assembly. The first orientation permits distal movement of the liner assembly relative to the coupling assembly prior to rotation of the elongate body to rotate the tissue-removing element. The second orientation is relative to the coupling assembly after rotation of the elongate body to prevent distal movement of the liner assembly relative to the coupling assembly.

Abstract: Systems and methods that automatically adjust, or adapt, stimulation waveforms delivered to brain structures. Closed loop system embodiments can automatically be re-configured into a more suitable closed loop control system in response to measures of control system performance. Measures can be internal performance characteristics of the adaptive control system or external inputs provided by another subsystem. As these measures change in time, the robust adaptive system changes in response.

Abstract: A medical system is configured to deliver an implantable medical device to a targeted implant site. The system may include a processor configured to receive a cardiac electrical signal and determine a feature of the cardiac electrical signal. The processor may be configured to determine a position of the delivery tool based on at least one feature of the cardiac electrical signal. The processor may detect a deployment position of the delivery tool in response to the cardiac electrical signal feature meeting criteria for detecting the deployment position.

Abstract: Systems, devices, methods, and techniques are described for using evoked compound action potential (ECAP) signals to monitor lead position and/or detect lead migration. An example system includes sensing circuitry configured to sense an ECAP signal, and processing circuitry. The processing circuitry controls the sensing circuitry to detect, after delivery of an electrical stimulation pulse, a current ECAP signal, and determines one or more characteristics of the current ECAP signal. The processing circuitry also compares the one or more characteristics of the current ECAP signal to corresponding one or more characteristics of a baseline ECAP signal, and determines, based on the comparison, a migration state of the electrodes delivering the electrical stimulation pulse. Additionally, the processing circuitry outputs, based on the migration state, an alert indicative of migration of the electrodes.

Abstract: A paravalvular leak resistant prosthetic heart valve system including a stent frame, a valve structure and a sealing mechanism. The stent frame has a surface. The valve structure is associated with the stent frame. The sealing mechanism at least partially extends over the surface of the stent frame. The sealing mechanism includes at least one semi-permeable membrane and an osmotic gradient driving material.

Abstract: A method for ablating tissue by applying at least one pulse train of pulsed-field energy. The method includes delivering a pulse train of energy having a predetermined frequency to cardiac tissue, the pulse train including at least 60 pulses, an inter-phase delay between 0 ?s and 5 ?s, an inter-pulse delay of at least 5 ?s, and a pulse width of 5 ?s.

Abstract: A nerve integrity monitoring device includes a control module and a physical layer module. The control module is configured to generate a payload request. The payload request (i) requests a data payload from a sensor in a wireless nerve integrity monitoring network, and (ii) indicates whether a stimulation probe device is to generate a stimulation pulse. The physical layer module is configured to (i) wirelessly transmit the payload request to the sensor and the stimulation probe device, or (ii) transmit the payload request to a console interface module. The physical layer module is also configured to, in response to the payload request, (i) receive the data payload from the sensor, and (ii) receive stimulation pulse information from the stimulation probe device. The data payload includes data corresponding to an evoked response of a patient. The evoked response is generated based on the stimulation pulse.

Abstract: An implantable medical device assembly comprises a sealed housing; a motor including a rotating output shaft within the sealed housing; a first coaxial shaft within the sealed housing, the first coaxial shaft being mechanically coupled to the rotating output shaft such that rotation of the rotating output shaft drives rotation of the first coaxial shaft; a second coaxial shaft external to the sealed housing, the second coaxial shaft being in axial alignment with the first coaxial shaft; an oscillating component mechanically coupling the first coaxial shaft to the second coaxial shaft, wherein rotation of the rotating first coaxial shaft drives the oscillation of the oscillating component, wherein the oscillation of the oscillating component drives rotation of the second coaxial shaft; and a flexible seal including the oscillating component. The sealed housing and the flexible seal combine to form a substantially sealed enclosure encasing the motor and the first coaxial shaft.

Abstract: Embodiments of the invention provide compositions useful in implantable devices such as analyte sensors as well as methods for making and using such compositions and devices. In typical embodiments of the invention, the device is a glucose sensor comprising a polymeric composition disposed on a flexible assembly within the sensor that includes amounts of one or more immunosuppressant agents designed to provide such sensors with improved material properties such as enhanced biocompatibility.

Abstract: A medical system for obstructive sleep apnea (OSA) treatment includes therapy delivery circuitry configured to output one or more electrical stimulation signals to a tongue of a patient; sensing circuitry configured to sense one or more compound muscle action potential (CMAP) signals, wherein the one or more CMAP signals are generated in response to the delivery of the one or more electrical stimulation signals; and processing circuitry configured to: cause the therapy delivery circuitry to output the one or more electrical stimulation signals to the tongue; receive information indicative of the one or more CMAP signals from the sensing circuitry; determine, based on the one or more CMAP signals, one or more therapeutic stimulation parameters for the OSA treatment; and cause the therapy delivery circuitry to deliver therapeutic electrical stimulation signals according to at least the determined one or more therapeutic stimulation parameters.

Abstract: A processor-implemented method includes causing fluid delivery to a patient based on a first value for a control parameter, identifying a second value for the control parameter based on a determination that a current operational context is associated with the second value, and causing fluid delivery to the patient based on the second value for the control parameter in lieu of the first value for the control parameter.

Abstract: Devices and methods described herein facilitate rapid wireless recharging, while reducing risk of injury, damage, or discomfort caused by heat generated during recharging. The embodiments described herein are useful in a variety of context, including for IoT devices, personal electronics, electric vehicles, and medical devices, among others. Such devices can prevent localized overheating of the device.

Abstract: This invention pertains to systems and components useful for infusing medications such as insulin. Typically, the components are used to deliver insulin to a diabetic patient at a site of infusion over a period of time greater than 4 days. The system components typically comprise a cannula adapted for subcutaneous insertion into a diabetic patient. The system further comprises a fluid conduit adapted to deliver the insulin solution from a medication reservoir to the site of infusion and a depot in operable contact with the fluid conduit. The depot comprises selected materials including a site-loss mitigating agent (such as heparin) which inhibits inflammation at the site of infusion, and encapsulation of the cannula at the site of infusion. The site-loss mitigating agent is not premixed with the insulin, and instead is adapted to contact the insulin solution in the depot as the insulin solution flows from the medication reservoir to the site of infusion.

Abstract: A delivery system for delivering a device to a body lumen includes an inner shaft coupled to a distal tip and an outer sheath slidingly disposed over the inner shaft. The outer sheath is configured to hold the device in a radially compressed configuration. The outer sheath includes a proximal capsule and a distal capsule. The delivery system further includes a removable sleeve configured to couple the proximal capsule to the distal capsule during loading of the device into the delivery system. A distal end of the distal capsule is configured to interlock with the distal tip after the device is loaded into the delivery system.

Abstract: The present application relates to an occlusion device for occluding a left atrial appendage. The device has an expandable hollow body with an internal volume. The expandable body includes a proximal portion having a first diameter, wherein the proximal portion is arranged to sealingly engage against an opening of the left atrial appendage, a distal portion having a second diameter, wherein the distal portion is arranged to be positioned inside and at least partially fill the left atrial appendage and a central portion extending between the proximal and distal portion, wherein the central portion comprises a waist region with a third diameter. The third diameter of the waist region is smaller than the first diameter of the proximal portion and the second diameter of the distal portion.